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March, 15th, 2024 NOTICE
The CASE 2024 Symposium will be held on Friday, April 12, 2024 at the Chemistry Main Building, School of Science, The University of Tokyo.
You can download a poster from here.
February, 19th, 2024 New!
Our paper "Development of Catalytic Enantioselective Mannich Reactions Using Esters" was published in Org. Lett..
February, 8th, 2024 New!
Our paper "Continuous Synthesis of Homoallylic Ketones via Ketal–Claisen Rearrangement using Solid-Acid Catalysts" was published in Org. Chem. Front..
January, 26th, 2024 New!
Our paper "Continuous-Flow Enantioselective Hydrogenative Enyne Cyclization with Chiral Heterogeneous Rh Catalysts" was published in ACS Catal..
January, 18th, 2024 New!
Our paper "Enantioselective Acyl-Transfer/Protonation Reactions with Newly Designed Chiral Thiourea-Iminophosphorane Catalysts" was published in Adv. Synth. Catal..
January, 13th, 2024 New!
Our paper "Water vs. Organic Solvents: Water-Controlled Divergent Reactivity of 2-Substituted Indoles" was published in Chem. Asian J..
January, 12th, 2024 New!
Our paper "Continuous-Flow Asymmetric Hydrogenation for the Synthesis of an (S)-Metolachlor Intermediate Using Catalysts Immobilized on a Core/Shell-Type Support" was published in Adv. Synth. Catal..
December, 21st, 2023 New!
Former Project Assistant Professor Yasukawa Tomohiro (currently Research Fellow at ESPCI Paris) received the Chemical Society of Japan Award for Young Chemists.
December, 12th, 2023 New!
Assistant Professor Taku Kitanosono received the Incentive Award in Synthetic Organic Chemistry, Japan.
November, 28th, 2023
Our paper "Impact of gas-solid direct contact on gas-liquid-solid reaction performance in a flow reactor" was published in J. Flow Chem..
November, 24th, 2023
A press release was issued regarding "New catalysts for continuous synthesis of fine chemicals".
November, 22nd, 2023
Our paper "Continuous-Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts" was published in Angew. Chem. Int. Ed..
November, 20th, 2023
Our paper "Development of Photoredox-assisted Direct a-Alkylation Reactions of Ketones with Arylalkenes using a Catalytic Amount of LiO t Bu as a Brønsted Base" was published in Helv. Chim. Acta.
October, 17th, 2023
Our paper "Photoinduced Efficient Catalytic α-Alkylation Reactions of Active Methylene and Methine Compounds with Nonactivated Alkenes" was published in J. Am. Chem. Soc..
September, 6th, 2023
Our paper "Highly enantioselective hydroxymethylation of unmodified α-substituted aryl ketones in water" was published in Proc. Jpn. Acad., Ser. B.
September, 5th, 2023
Our paper "Aluminium-catalysed synthesis of aryl enol ethers from phenols and dimethyl ketals" was published in Org. Biomol. Chem..
August, 29th, 2023
Our paper "Continuous-flow dehydrative amidation between carboxylic acids and amines using modified mixed metal oxides as solid acid catalysts" was published in Catal. Sci. Technol..
August, 18th, 2023
Our paper "Bead Mill-Driven Acceleration of Catalytic Methanolysis of Poly(ethylene terephthalate) under Mild Reaction Conditions" was published in Chem. Lett..
August, 7th, 2023
A press release was issued regarding "Continuous-flow manufacturing of essential antibiotic cefazolin enables more flexible production while reducing cost and waste".
August, 7th, 2023
Our paper "A Practical and Convenient Synthesis of the Essential Antibiotic Drug Cefazolin under Sequential One-Flow Conditions" was published in Bull. Chem. Soc. Jpn..
Prof. Shū Kobayashi, Proj. Prof. Haruro Ishitani, and Dr. Shoichi Sugita recieved the BCSJ Award Article for this paper.
August, 2nd, 2023
Our paper "Continuous-flow Reductive N-Methylation with Highly Active Heterogeneous Pd Catalysts and Sequential-flow Synthesis of N-Monomethyl Amines" was published in Green Chem..
July, 11th, 2023
Our paper "A Chronicle of Organic Synthesis in Water: A Trajectory of Growth in the Intervening Quarter Century" was published in Tetrahedron.
June, 23rd, 2023
Our paper "Continuous Synthesis of Epoxides from Alkenes by Hydrogen Peroxide with Titanium Silicalite-1 Catalyst Using Flow Reactors" was published in Adv. Synth. Catal.
May, 25th, 2023
Our paper "Heterogeneous Single-Atom Zinc on Nitrogen-Doped Carbon Catalyzed Electrochemical Allylation of Imines" was published in J. Am. Chem. Soc.
May, 8th, 2023
Our paper "A Continuous-Flow Method for the Transformation from Amides to Nitriles Catalyzed by CeO2 in Acetonitrile" was published in Adv. Synth. Catal.
May, 8th, 2023
Our paper "Catalytic hydrogenative dechlorination reaction for efficient synthesis of a key intermediate of SDHI fungicides under continuous-flow conditions" was published in Catal. Sci. Technol.
April, 26th, 2023
Our paper "New Usage of Molecular Sieve" was published in J. Synth. Org. Chem. Jpn.
April, 26th, 2023
Ms. Julie Kong (D3 student) received CSJ Student Presentation Award 2023 in The 103rd CSJ Annual Meeting.
April, 7th, 2023
Our paper "Liquid-phase Catalytic Continuous-Flow Aromatic Nitration Reactions with Conc. HNO3 on Modified Mixed-Metal Oxide Composites as High-Yielding Solid Acid Catalysts" was published in ACS Sus. Chem. Eng.
March, 29th, 2023
Our paper "Continuous-Flow Enantioselective 1,4-Addition Reactions of Malonates with Nitroolefins on Ni-Supported Mesoporous Silica Materials with Co-feeding of a Chiral Ligand" was published in Adv. Synth. Catal.
December, 16th, 2022
Ph.D. thesis of Proj. Asst. Prof. Yuki Saito has been published as a book.
November, 29th, 2022
Our paper "Development of Metal-Free, Trifluoromethanesulfonic Acid-Immobilized Nitrogen-Doped Carbon Catalysts for Povarov Reactions" was published in J. Org. Chem..
October, 7th, 2022
A miniature of our laboratory's equipment was exhibited in the Science Gallery. Click here for the introduction
September, 29th, 2022
Our paper "Effect of Activation Methods of Molecular Sieves on Ketimine Synthesis" was published in J. Org. Chem..
August, 31st, 2022
Our paper "Continuous-flow Oxidation of Alcohols" was published in Adv. Synth. Catal..
August, 29th, 2022
Our paper "Continuous-flow Diels-Alder Reactions of Unactivated Dienes over Zeolitic Catalysts" was published in Asian J. Org. Chem..
August, 15th, 2022
Our paper "Continuous-Flow Synthesis of β-Ketoesters" was published in Adv. Synth. Catal..
July, 25th, 2022
Our paper "Photocatalytic Addition Reactions of Ketene Silyl Acetals with Alkenes" was published in Chem. Asian J..
July, 16th, 2022
Our paper "Hydrogen generation from organic hydride under continuus-flow conditions" was published in Chem. Asian J..
June, 3rd, 2022
The book chapter "CONTINUOUS-FLOW CHEMISTRY IN CATALYTIC ASYMMETRIC SYNTHESIS" was published in Catalytic Asymmetric Synthesis, Fourth Edition..
June, 2nd, 2022
Dr. Tomohiro Yasukawa (Project assistant professor, GSC lab.) was awarded for The 21th Green and Sustainable Chemistry Incentive Award.
May, 25th, 2022
Our paper "On-water nitration" was published in Chem. Asian J..
May, 6th, 2022
Our paper "Reusable Lewis acid catalyst for asymmetric reactions in water" was highlighted in Nature Synthesis.
May, 3rd, 2022
Our paper "Homologation of Aryl Aldehydes Using Nitromethane as a C1 Source" was published in ACS Catal..
April, 28th, 2021
Mr. Tomoya Hisada (D3 student) received CSJ Student Presentation Award 2022 in The 102nd CSJ Annual Meeting.
April, 1st, 2022
Dr. Tatsuya Kuremoto was appointed as the project assistant professor.
March, 31th, 2022
Our paper "Cooperative catalytic systems: metal nanoparticles and Lewis acids in arene hydrogenation" was published in Angewt. Chem., Int. Ed..
March, 31th, 2022
Our paper "Reusable Lewis acid catalyst for asymmetric reactions in water" was published in Angewt. Chem., Int. Ed..
March, 16th, 2022
Our paper "Water-driven solid self-assembled catalysis" was published in J. Organomet. Chem..
February, 9th, 2022
Our paper "Nitrogen-Doped Carbon-Incarcerated Zinc Electrodes for Electrochemical Allylation" was published in J. Org. Chem..
February, 7th, 2022
Dr. Tomohiro Yasukawa (Project assistant professor, GSC lab.) was awarded for PCCP Prize.
January, 31th, 2022
Our paper "Brønsted Base-Catalyzed Imino-Ene-Type Allylation Reactions" was published in Chem. Commun..
January, 23th, 2022
Our paper "Continuous-flow synthesis of Tamsulosin" was published in Angew. Chem., Int. Ed..

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Selected as cover picture of
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Metal amide as the simplest
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Tandem reactions using
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