Publication List (2024)

Development of Continuous-Flow Reactions for the Synthesis of Anti-Alzheimer Drug Memantine

M. Iwata, Y. Furiya, H. Ishitani*, S. Kobayashi*

Chem. Eur. J., , Accepted Article (2024). DOI: 10.1002/chem.202403562

Continuous-flow synthesis of cyclic carbonates with polymer-supported imidazolium-based ionic liquid (Im-PSIL) catalysts

Z. Yu, H. Ishitani*, S. Kobayashi*

Green Chem., , Advance Article (2024). DOI: 10.1039/D4GC04499A

Structure-Directed Quaternary Ammonium Hydroxide Resins: High-Performance Heterogeneous Base Catalysts for Continuous-Flow Carbon–Carbon Bond-Forming Reactions

H. Ishitani*, Y. Furiya, A. Ide, S. Kobayashi*

J. Org. Chem., 89, 14081-14089 (2024). DOI: 10.1021/acs.joc.4c01506

Solid-Acid Catalyzed Continuous-Flow Aminolysis of Epoxides

K. Nishizawa, Y. Saito, S. Kobayashi*

Chem. Eur. J., Early View e202403094 (2024). DOI: 10.1002/chem.202403094

Sequential-Flow Synthesis of Donepezil: A Green and Sustainable Strategy Featuring Heterogeneous Catalysis and Hydrogenation

H. Ishitani*, H. Sogo, Y. Furiya, S. Kobayashi*

Chem. Eur. J., 30, e202402128 (2024). DOI: 10.1002/chem.202402128

Cover Art

Press release: 「水素で作る抗アルツハイマー薬――副産物は水のみ。未来の医薬品生産へ――」

TEMPO-Catalyzed Continuous-flow Aerobic Oxidations of Alcohols on Silica

K. Takizawa*, T. Ishihara, S. Tani, Y. Hamada, K. Masuda, S. Onozawa*, K. Sato, S. Kobayashi*

ChemCatChem, Accepted Article (2024). DOI: 1002/cctc.202401152

Vigorously Stirred La2O3 Suspensions for Michael Additions in Water

T. Hisada, R. Osada, T. Kitanosono*, Y. Yamashita, S. Kobayashi*

Chem. Commun., 60, 9994-9996 (2024). DOI: 10.1039/D4CC02343A

Small-Molecule-Based Strategy for Mitigating Deactivation of Chiral Lewis Acid Catalysis

F. Lu, T. Kitanosono*, Y. Yamashita, S. Kobayashi*

J. Am. Chem. Soc., 146, 22918-22922 (2024). DOI: 10.1021/jacs.4c07449

Direct Aromatic Nitrosation Using 2-Methoxyethyl Nitrite as a NO Cation Source

A. Hashidoko, T. Kitanosono*, Y. Yamashita, S. Kobayashi*

Org. Lett., 26, 5517-5521. DOI: 10.1021/acs.orglett.4c01856

Continuous-flow Directed C–H Amidation Reactions Using Immobilized Cp*Rh(III) Catalysts

Y. Saito, T. Konno, S. Kobayashi*

Green Chem., 26 8680-8684 (2024). DOI: 10.1039/D4GC01747A

Selective Hydrogenation of Quinizarins to Leuco-quinizarins and Their Direct Derivatization Using Flow-Batch-Separator Unified Reactors under Continuous-Flow Conditions

H. Miyamura*, A. Sharma, M. Takata, R. Kajiyama, S. Kobayashi, Y. Kon

ACS Catal., 14, 10317-10323 (2024). DOI: 10.1021/acscatal.4c02955

Catalytic Activation of Bis(2,2,2-trifluoroethyl) phosphite with Hf(IV) for the Synthesis of Mixed Dialkyl Phosphites

D. Mrdović, Y. Saito, S. Kobayashi*

Adv. Synth. Catal., 366, 3822-3828 (2024). DOI: 10.1002/adsc.202400497

Flow Chemistry and Continuous Processing: More Mainstream than Ever!

K. P. Cole*, J. N. Jaworski, C. O. Kappe, S. Kobayashi, A. R. Maguire, A. O’Kearney-McMullan, J. A. Pesti

Org. Process Res. Dev., 28, 1269-1271 (2024). DOI: 10.1021/acs.oprd.3c00483

Nanoscale and chiral metal–organic frameworks for asymmetric reactions in water: bridging Lewis acid catalysis and biological systems

W. Srimontree, T. Kitanosono*, Y. Yamashita, S. Kobayashi*

Chem. Sci., 15, 9120-9126 (2024). DOI: 10.1039/D4SC01343C

Efficient Radical-mediated Intermolecular α-Alkylation Reactions of Carbonyl Compounds with Nonactivated Alkenes

Y. Yamashita, S. Kobayashi*

Chem. Asian J., 19, e202400319 (2024). DOI: 10.1002/asia.202400319

Reductive N-Alkylation of Amines with Ketones Using Heterogeneous Polysilane–Palladium Catalysts under Continuous-Flow Conditions

T. Senzaki, Y. Saito, S. Kobayashi*

Org. Lett., 26, 3772-3777 (2024). DOI: 10.1021/acs.orglett.4c00876

A Highly Efficient Catalytic Method for the Synthesis of Phosphite Diesters

Y. Saito, S. M. Cho, L. A. Danieli, A. Matsunaga, S. Kobayashi*

Chem. Sci., 15, 8190-8196 (2024). DOI: 10.1039/D4SC01401D

Development of Catalytic Enantioselective Mannich Reactions Using Esters

Y. Yamashita*, S. Fushimi, T. Banik, T. Kimura, S. Kobayashi*

Org. Lett., 26, 1579-1583 (2024). DOI: 10.1021/acs.orglett.3c04326

Continuous Synthesis of Homoallylic Ketones via Ketal–Claisen Rearrangement using Solid-Acid Catalysts

K. Kobayashi*, C. Negoro, J. Takaishi, K. Masuda*, S. Kobayashi*

Org. Chem. Front., 11, 1990-1995 (2024). DOI: 10.1039/D3QO01889J

Continuous-Flow Enantioselective Hydrogenative Enyne Cyclization with Chiral Heterogeneous Rh Catalysts

Y. Saito, Y. Sato, S. Kobayashi*

ACS Catal., 14 2202-2206 (2024). DOI: 10.1021/acscatal.3c05868

Enantioselective Acyl-Transfer/Protonation Reactions with Newly Designed Chiral Thiourea-Iminophosphorane Catalysts

J. Kong, C. Lacroix, C. Bournaud, Y. Yamashita, S. Kobayashi*, G. Vo-Tanh*

Adv. Synth. Catal., 366, 1101-1106 (2024). DOI: 10.1002/adsc.202301394

Water vs. Organic Solvents: Water-Controlled Divergent Reactivity of 2-Substituted Indoles

A. Hashidoko, T. Kitanosono*, Y. Yamashita, S. Kobayashi*

Chem. Asian J., 19, e202301045 (2024). DOI: 10.1002/asia.202301045

Continuous-Flow Asymmetric Hydrogenation for the Synthesis of an (S)-Metolachlor Intermediate Using Catalysts Immobilized on a Core/Shell-Type Support

T. Kuremoto, T. Yasukawa, S. Kobayashi*

Adv. Synth. Catal., 366, 757-761 (2024). DOI: 10.1002/adsc.202301251