Takayuki Katoh, Ph.D.

Associate Professor


B.Sc., School of Engineering, The University of Tokyo
Thesis advisor: Prof. Kimitsuna Watanabe
M.Sc., Graduate School of Engineering, The University of Tokyo
Thesis advisor: Prof. Kimitsuna Watanabe
Ph.D., Graduate School of Engineering, The University of Tokyo
Thesis advisor: Prof. Tsutomu Suzuki

Professional career

Research Fellow, iGENE therapeutics, Co., Inc.
Research fellow, Japan biological informatics consortium
Assistant professor, Research Center for Advanced Science and Technology, The University of Tokyo
Assistant professor, Graduate School of Science, The University of Tokyo
Investigator, PRESTO, Japan Science and Technology Agency (Concurrent post)
Associate Professor, Department of Chemistry, Graduate School of Science, The University of Tokyo


"Flexizyme-catalyzed synthesis of 3'-aminoacyl-NH-tRNAs."
T. Katoh; H. Suga
Nucleic Acids Res, (2019)
"Ribosomal Synthesis of Backbone-Cyclic Peptides Compatible with In Vitro Display."
R. Takatsuji; K. Shinbara; T. Katoh; Y. Goto; T. Passioura; R. Yajima; Y. Komatsu; H. Suga
J. Am. Chem. Soc., 141, 2279-2287 (2019)
"Ribosomal incorporation of consecutive β-amino acids."
Katoh, T., Suga, H.
J. Am. Chem. Soc. in press (2018).
"Thioether macrocyclic peptides selected against TET1 compact catalytic domain inhibit TET1 catalytic activity."
Nishio, K., Belle, R., Katoh, T., Kawamura, A., Sengoku, T., Hanada, K., Ohsawa, N., Shirouzu, M., Yokoyama, S., Suga, H.
Chembiochem, 19, 979-985 (2018).
"Artificial division of codon boxes for expansion of the amino acid repertoire of ribosomal polypeptide synthesis."
Iwane, Y., Katoh, T., Goto, Y., Suga, H.
Methods Mol. Biol., 1728, 17-47 (2018).
“Logical engineering of D-arm and T-stem of tRNA that enhances D-amino acid incorporation”
Katoh, T., Iwane, Y., Suga, H.
Nucleic Acids Res., 45, 12601-12610 (2017).
"Efficient siRNA delivery by lipid nanoparticles modified with a nonstandard macrocyclic peptide for EpCAM-targeting."
Sakurai, Y., Mizumura, W., Murata, M., Hada, T., Yamamoto, S., Ito, K., Iwasaki, K., Katoh, T., Goto, Y., Takagi, A., Kohara, M., Suga, H., Harashima, H.
Mol. Pharm., 14, 3290-3298 (2017).
"Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis."
Shin, B.S., Katoh, T., Gutierrez, E., Kim, J.R., Suga, H., Dever, T.E.
Nucleic Acids Res., 45, 8392-8402 (2017).
"Highly selective inhibition of histone demethylases by de novo macrocyclic peptides."
Kawamura, A., Münzel, M., Kojima, T., Yapp, C., Bhushan, B., Goto, Y., Tumber, A., Katoh, T., King, O.N., Passioura, T., Walport, L.J., Hatch, S.B., Madden, S., Müller, S., Brennan, P.E., Chowdhury, R., Hopkinson, R.J., Suga, H., Schofield, C.J.
Nat. Commun., 8, 14773 (2017).
"Consecutive elongation of D-amino acids in translation."
Katoh, T., Tajima, K., Suga, H.
Cell Chem. Biol., 24, 46-54 (2017).
"A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX."
Terasaka, N., Futai, K., Katoh, T., Suga, H.
RNA, 22, 1918-1928 (2016).
"Essential structural elements in tRNA(Pro) for EF-P-mediated alleviation of translation stalling."
Katoh, T., Wohlgemuth, I., Nagano, M., Rodnina, M.V., Suga, H.
Nat. Commun., 7, 11657 (2016).
"tRid, an enabling method to isolate previously inaccessible small RNA fractions."
Futai, K., Terasaka, N., Katoh, T., Suga, H.
Methods, 106, 105-11 (2016).
"Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes."
Iwane, Y., Hitomi, A., Murakami, H., Katoh, T., Goto, Y., Suga, H.
Nat. Chem., 8, 317-25 (2016).
"A fluorescent imaging probe based on a macrocyclic scaffold that binds to cellular EpCAM."
Iwasaki, K., Goto, Y., Katoh, T., Yamashita, T., Kaneko, S., Suga, H.
J. Mol. Evol., 81, 210-7 (2015).
"Destabilization of microRNAs in human cells by 3' deadenylation mediated by PARN and CUGBP1."
Katoh, T., Hojo, H., Suzuki, T.
Nucleic Acids Res., 43, 7521-7534 (2015).
"An engineered ribosome-tRNAs pair functions orthogonally to the wildtype under an artificially programmed genetic code."
Terasaka, N., Hayashi, G., Katoh, T., Suga, H.
Nat. Chem. Biol., 10, 555-7 (2014).
"A macrocyclic peptide that serves as a cocrystallization ligand and inhibits the function of a MATE family transporter."
Hipolito, C.J., Tanaka, Y., Katoh, T., Nureki, O., Suga, H.
Molecules, 18, 10514-30 (2013).
"Structural basis for the drug extrusion mechanism by a MATE multidrug transporter."
Tanaka, Y., Hipolito, C.J., Maturana, A.D., Ito, K., Kuroda, T., Higuchi, T., Katoh, T., Kato, H.E., Hattori, M., Kumazaki, K., Tsukazaki, T., Ishitani, R., Suga, H., Nureki, O.
Nature, 496, 247-51 (2013).
“In Vitro Selection of Cyclic Peptides for Cocrystallization with a Multidrug and Toxic compound Extrusion Protein”
Hipolito, C.J., Tanaka, Y., Katoh, T., Nureki, O., Suga, H.
Biopolymers, 100, 238-239 (2013).
"Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation."
Iwasaki, K., Goto, Y., Katoh, T., Suga, H.
Org. Biomol. Chem., 10, 5783-6 (2012).
"Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers."
Reid, P.C., Goto, Y., Katoh, T., Suga, H.
Methods Mol. Biol., 805, 335-48 (2012).
"Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library."
Yamagishi, Y., Shoji, I., Miyagawa, S., Kawakami, T., Katoh, T., Goto, Y., Suga, H.
Chem. Biol., 18, 1562-1570 (2011).
"Flexizymes for genetic code reprogramming."
Goto, Y., Katoh, T., Suga, H.
Nat. Protoc., 6, 779-90 (2011).
"Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae."
Noma, A., Yi, S., Katoh, T., Takai, Y., Suzuki, T., Suzuki, T.
RNA, 17, 1111-9 (2011).
"Synthetic human cell fate regulation by protein-driven RNA switches."
Saito, H., Fujita, Y., Kashida, S., Hayashi, K., Katoh, T., Inoue, T.
Nat. Commun., 2, 160 (2011).
“Biogenesis of glutaminyl-mt tRNAGln in human mitochondria”
Nagao, A., Suzuki, T., Katoh, T., Sakaguchi, Y., Suzuki, T.
Proc. Natl. Acad. Sci. USA., 106, 16209-16214 (2009).
"Selective stabilization of mammalian microRNAs by 3’-adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2"
Katoh, T., Sakaguchi, Y., Miyauchi, K., Suzuki, T., Kashiwabara, S., Baba, T., Suzuki, T.
Genes Dev., 23, 433-438 (2009).
"Specific residues at every third position of siRNA shape its efficient RNAi activity"
Katoh, T., Suzuki, T.
Nucleic Acids Res., 35, e27 (2007).
"Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase"
Nagaike, T., Suzuki, T., Katoh, T., Ueda, T.
J. Biol. Chem., 280, 19721-19727 (2005).
"Simple and rapid synthesis of siRNA derived from in vitro transcribed shRNA"
Katoh, T., Susa, M., Suzuki, T., Umeda, N., Watanabe, K., Suzuki, T.
Nucleic Acids Res. Suppl., 3, 249-250 (2003).

Publication (Books and reviews in Japanese)

"Engineering translation components improve incorporation of exotic amino acids."
T. Katoh; H. Suga
Int J Mol Sci, 20, 522 (2019)
"In vitro expression of genetically encoded non-standard peptides consisting of exotic amino acid building blocks."
H. Hirose; C. Tsiamantas; T. Katoh; H. Suga
Curr Opin Biotechnol, 58, 28-36 (2018)
"Genetic code expansion via integration of redundant amino acid assignment by finely tuning tRNA pools."
Tajima, K., Katoh, T., Suga, H.
Curr. Opin. Chem. Biol., in press (2018)
"Advances in in vitro genetic code reprogramming in 2014–2017."
Katoh, T., Passioura, T., Suga, H.
Synth. Biol., in press (2018)
"Biological synthesis and affinity-based selection of small macrocyclic peptide ligands"
Passioura, T., Goto, Y., Katoh, T., Suga, H.
Cyclic Peptides: From Bioorganic Synthesis to Applications, 225-254 (2017).
"tRNA engineering for manipulating genetic code."
Katoh, T., Iwane, Y., Suga, H.
RNA Biol. 19, 1-8 (2017).
"Selection-Based Discovery of Druglike Macrocyclic Peptides."
Passioura, T., Katoh, T., Goto, Y., Suga, H.
Annu. Rev. Biochem., 83, 727-52 (2014).
"In vitro synthetic biology of the genetic code: its development and applications."
Suga, H., Hipolito, C.J., Goto, Y., Katoh, T., Bashiruddin, N.
Synth. Biol., 1, 126-63 (2014).
"Ribosomal synthesis of backbone macrocyclic peptides."
Katoh, T., Goto, Y., Reza, M.S., Suga, H.
Chem. Commun., 47, 9946-58 (2011).
木村寛之, 加藤敬行, 菅裕明
中分子創薬に資するペプチド・核酸・糖鎖の合成技術, 第8章 (2018)
岩根由彦, 高辻諒, 加藤敬行, 菅裕明
進化分子工学, 49-60 (2014).
加藤敬行, 菅裕明
新しい薬学事典 (2012).
加藤敬行, 後藤佑樹, 菅裕明
生命システム工学, 71-100 (2012).
山口淳, 加藤敬行, 菅 裕明
Drug Delivery System, 26, 584-592 (2011).
加藤敬行, 鈴木勉
実験医学,Vol.27, No.11, 1746-1750 (2009).
加藤敬行, 宮内健常, 鈴木勉
加藤敬行, 鈴木勉
「RNA実験ノート・下」(小分子RNAの解析からRNAiへの応用まで), 99-102 (2008).
鈴木勉, 加藤敬行
鈴木勉, 加藤敬行
「最新医学」, 第59巻, 第8号, 12-19 (2004).
加藤敬行, 鈴木勉
「最新医学」, 第59巻, 第8号, 20-25 (2004).
「in vitro転写反応による新規siRNA合成法とRNAi活性予測アルゴリズムの開発」
鈴木勉, 加藤敬行
「改訂 RNAi実験プロトコール」, 195-207 (2004).

Contact Info

  • Room #2207, West wing, Chemistry Bildg.
    Department of Chemistry, Graduate School of Science, The University of Tokyo
  • E-mail… katoh"at"chem.s.u-tokyo.ac.jp (change "at" to @)
  • TEL…+81-3-5841-4638
  • FAX…+81-3-5841-8372