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Haruo Aikawa

Assistant Professor


City/country of origin
Tsukuba, Ibaraki
Hobbies
Trip, Driving, Hot spring, Visiting waterfalls, and I’m a foodie!
Places You Like
Nature with a little artificial thing (park, garden etc)
Where for a big vacation
Visiting “World Heritage” sites
What are your strong points?
Enjoying a meal, Enjoying a challenge
Music: what is some intense music for intense lab work?
“It’s My Life” for now
What are people in the lab doing?
Struggling
What was surprising about the suga lab
Freedom
Original motivation towards science?
To test my idea to find unexpected results
A few words for future lab mates
Try anything!
Science is…….
to create new common knowledge

Education & professional career

2004
B.Sc. Department of Chemistry, Fac. of Science, Tohoku University
2006
M.Sc. Department of Chemistry, Fac. of Science, Tohoku University
2009
Ph. D. Department of Chemistry, Fac. of Science, Tohoku University
2009-2011
Assistant Professor, Tohoku University (Prof. Masahiko Yamaguchi)
2011-2013
Specially Appointed Assistant Professor, Tokyo Medical and Dental University (Prof. Hirokazu Tamamura)
2013-2018
Specially Appointed Assistant Professor, Osaka University (Prof. Kazuhiko Nakatani)
2018-2021
Postdoctoral Associate, The Scripps Research Institute (Prof. Matthew Disney)
2021-2022
Postdoctoral Researcher, The University of Tokyo (Prof. Hiroaki Suga)
2022-
Assistant Professor, The University of Tokyo (Prof. Hiroaki Suga)


Publications

"Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion."
Q.M.R. Gibaut; Y. Akahori; J.A. Bush; A. Taghavi; T. Tanaka; H. Aikawa; L.S. Ryan; B.M. Paegel; M.D. Disney
J Am Chem Soc, (2022)
"A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G(4)C(2))(exp) in c9ALS/FTD via the nuclear RNA exosome."
J.A. Bush; S.M. Meyer; R. Fuerst; Y. Tong; Y. Li; R.I. Benhamou; H. Aikawa; P.R.A. Zanon; Q.M.R. Gibaut; A.J. Angelbello; T.F. Gendron; Y.J. Zhang; L. Petrucelli; T. Heick Jensen; J.L. Childs-Disney; M.D. Disney
Proc Natl Acad Sci U S A, 119, e2210532119 (2022)
"A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype."
H.S. Haniff; X. Liu; Y. Tong; S.M. Meyer; L. Knerr; M. Lemurell; D. Abegg; H. Aikawa; A. Adibekian; M.D. Disney
Cell Chem Biol, (2021)
"Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models."
J.A. Bush; H. Aikawa; R. Fuerst; Y. Li; A. Ursu; S.M. Meyer; R.I. Benhamou; J.L. Chen; T. Khan; S. Wagner-Griffin; M.J. Van Meter; Y. Tong; H. Olafson; K.K. McKee; J.L. Childs-Disney; T.F. Gendron; Y. Zhang; A.N. Coyne; E.T. Wang; I. Yildirim; K.W. Wang; L. Petrucelli; J.D. Rothstein; M.D. Disney
Sci Transl Med, 13, eabd5991 (2021)
"Small molecule recognition of disease-relevant RNA structures."
S.M. Meyer; C.C. Williams; Y. Akahori; T. Tanaka; H. Aikawa; Y. Tong; J.L. Childs-Disney; M.D. Disney
Chem Soc Rev, 49, 7167-7199 (2020)
"Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands."
X. Liu; H.S. Haniff; J.L. Childs-Disney; A. Shuster; H. Aikawa; A. Adibekian; M.D. Disney
J Am Chem Soc, 142, 6970-6982 (2020)
"Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer."
M.G. Costales; H. Aikawa; Y. Li; J.L. Childs-Disney; D. Abegg; D.G. Hoch; S.P. Velagapudi; Y. Nakai; T. Khan; K.W. Wang; I. Yildirim; A. Adibekian; E.T. Wang; M.D. Disney
P Natl Acad Sci USA, 117, 2406-2411 (2020)
"Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing."
J.L. Chen; P. Zhang; M. Abe; H. Aikawa; L. Zhang; A.J. Frank; T. Zembryski; C. Hubbs; H. Park; J. Withka; C. Steppan; L. Rogers; S. Cabral; M. Pettersson; T.T. Wager; M.A. Fountain; G. Rumbaugh; J.L. Childs-Disney; M.D. Disney
J Am Chem Soc, 142, 8706-8727 (2020)
"Expanding chemical space of DNA-binding molecules with three base-binding units."
Y. Yagi; H. Aikawa; T. Yamada; K. Nakatani
Bioorg Med Chem Lett, 28, 2894-2898 (2018)
"A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH."
H. Aikawa; A. Yano; K. Nakatani
Org Biomol Chem, 15, 1313-1316 (2017)
"Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization."
T. Nakamura; J.R. Campbell; A.R. Moore; S. Otsu; H. Aikawa; H. Tamamura; H. Mitsuya
J Virol Methods, 236, 196-206 (2016)
"Exploration of labeling by near infrared dyes of the polyproline linker for bivalent-type CXCR4 ligands."
W. Nomura; H. Aikawa; S. Taketomi; M. Tanabe; T. Mizuguchi; H. Tamamura
Bioorg Med Chem, 23, 6967-6973 (2015)
"Exploratory Study on the RNA-Binding Structural Motifs by Library Screening Targeting pre-miRNA-29 a."
T. Fukuzumi; A. Murata; H. Aikawa; Y. Harada; K. Nakatani
Chemistry, 21, 16859-16867 (2015)
"Synthesis of 8-Substituted Adenine and Adenosine Libraries and the Binding to pre-miR-29a."
T. Fukuzumi; H. Aikawa; Y. Harada; A. Sugai; A. Murata; K. Nakatani
B Chem Soc Jpn, 87, 1013-1015 (2014)
"Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products."
W. Nomura; H. Aikawa; N. Ohashi; E. Urano; M. Metifiot; M. Fujino; K. Maddali; T. Ozaki; A. Nozue; T. Narumi; C. Hashimoto; T. Tanaka; Y. Pommier; N. Yamamoto; J.A. Komano; T. Murakami; H. Tamamura
ACS Chem Biol, 8, 2235-2244 (2013)
"Low-molecular-weight CXCR4 ligands with variable spacers."
T. Narumi; H. Aikawa; T. Tanaka; C. Hashimoto; N. Ohashi; W. Nomura; T. Kobayakawa; H. Takano; Y. Hirota; T. Murakami; N. Yamamoto; H. Tamamura
ChemMedChem, 8, 118-124 (2013)
"Pharmacophore-based small molecule CXCR4 ligands."
T. Narumi; T. Tanaka; C. Hashimoto; W. Nomura; H. Aikawa; A. Sohma; K. Itotani; M. Kawamata; T. Murakami; N. Yamamoto; H. Tamamura
Bioorg Med Chem Lett, 22, 4169-4172 (2012)
"Stereoselective formation of trisubstituted (Z)-chloroalkenes adjacent to a tertiary carbon stereogenic center by organocuprate-mediated reduction/alkylation."
T. Narumi; T. Kobayakawa; H. Aikawa; S. Seike; H. Tamamura
Org Lett, 14, 4490-4493 (2012)
"Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines."
C. Hashimoto; W. Nomura; A. Ohya; E. Urano; K. Miyauchi; T. Narumi; H. Aikawa; J.A. Komano; N. Yamamoto; H. Tamamura
Bioorg Med Chem, 20, 3287-3291 (2012)
"Formation of double helix self-assembled monolayers of ethynylhelicene oligomer disulfides on gold surfaces."
K. Yamamoto; H. Sugiura; R. Amemiya; H. Aikawa; Z.J. An; M. Yamaguchi; M. Mizukami; K. Kurihara
Tetrahedron, 67, 5972-5978 (2011)
"Synthesis of 1,8-di(1-adamantyl)naphthalenes as single enantiomers stable at ambient temperatures."
H. Aikawa; Y. Takahira; M. Yamaguchi
Chem Commun (Camb), 47, 1479-1481 (2011)
"Gold-catalyzed alkylation of silyl enol ethers with ortho-alkynylbenzoic acid esters."
H. Aikawa; T. Kaneko; N. Asao; Y. Yamamoto
Beilstein J Org Chem, 7, 648-652 (2011)
"Gold-catalyzed substitution reaction with ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent."
H. Aikawa; S. Tago; K. Umetsu; N. Haginiwa; N. Asao
Tetrahedron, 65, 1774-1784 (2009)
"Gold-catalyzed etherification and Friedel-Crafts alkylation using ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent."
N. Asao; H. Aikawa; S. Tago; K. Umetsu
Org Lett, 9, 4299-4302 (2007)
"Lewis acid-catalyzed [4 + 2] benzannulation between enynal units and enols or enol ethers: novel synthetic tools for polysubstituted aromatic compounds including indole and benzofuran derivatives."
N. Asao; H. Aikawa
J Org Chem, 71, 5249-5253 (2006)
"AuBr(3)-catalyzed [4 + 2] benzannulation between an enynal unit and enol."
N. Asao; H. Aikawa; Y. Yamamoto
J Am Chem Soc, 126, 7458-7459 (2004)

Contact info

    • E-mail… aikawa.haruo"at"mail.u-tokyo.ac.jp (change "at" to @)