Alex Vinogradov

Project Assistant Professor

Hobbies

Coding, data

Places You Like

Anywhere is fine really

Where for a big vacation

Antarctica and subantarctic islands. Would love to hang out with penguins for a few months

What are your strong points?

I am really good at differentiating colors

Music: what is some intense music for intense lab work?

残酷な天使のように、少年よ、神話になれ！

What are people in the lab doing?

Science, I guess

What was surprising about the suga lab

The number of thermal cyclers in lab. I knew there would be a lot, but still...

Original motivation towards science?

None: one random event led to another, and here I am!

A few words for future lab mates

今日も一日がんばるぞい！

Science is…….

hard.

Education & professional career

2012-2017

Ph.D., Prof. Bradley Pentelute, Massachusetts Institute of Technology, MA, USA

2007-2012

Specialist in chemistry, Prof. Nikolay Zyk, Lomonosov Moscow State University, Moscow, Russia

Publications

"Solid-Phase-Based Synthesis of Lactazole-Like Thiopeptides."

Y. Zhang; A.A. Vinogradov; J.S. Chang; Y. Goto; H. Suga

Organic Letters, 24, 7894-7899 (2022)

"De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors."

A.A. Vinogradov; Y. Zhang; K. Hamada; J.S. Chang; C. Okada; H. Nishimura; N. Terasaka; Y. Goto; K. Ogata; T. Sengoku; H. Onaka; H. Suga

Journal of the American Chemical Society, 144, 20332-20341 (2022)

"Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning."

A.A. Vinogradov; J.S. Chang; H. Onaka; Y. Goto; H. Suga

ACS Central Science, 8, 814-824 (2022)

"Site-Specific Nonenzymatic Peptide S/O-Glutamylation Reveals the Extent of Substrate Promiscuity in Glutamate Elimination Domains."

A.A. Vinogradov; M. Nagano; Y. Goto; H. Suga

Journal of the American Chemical Society, 143, 13358-13369 (2021)

"Minimal lactazole scaffold for in vitro thiopeptide bioengineering."

A.A. Vinogradov; M. Shimomura; Y. Goto; Y. Sugai; H. Suga; H. Onaka

Nature Communications, 11, 2272 (2020)

"Accurate Broadcasting of Substrate Fitness for Lactazole Biosynthetic Pathway from Reactivity-Profiling mRNA Display."

A.A. Vinogradov; E. Nagai; J.S. Chang; K. Narumi; H. Onaka; Y. Goto; H. Suga

Journal of the American Chemical Society, 142, 20329-20334 (2020)

"Macrocyclic Peptides As Drug Candidates: Recent Progress and Remaining Challenges."

A.A. Vinogradov; Y. Yin; H. Suga

Journal of the American Chemical Society, 141, 4167-4181 (2019)

"Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides."

S.R. Fleming; T.E. Bartges; A.A. Vinogradov; C.L. Kirkpatrick; Y. Goto; H. Suga; L.M. Hicks; A.A. Bowers

Journal of the American Chemical Society, 141, 758-762 (2019)

"Access to 5-fluoroisoxazoles via the nitrosation of geminal bromo-fluoro arylcyclopropanes."

O.B. Bondarenko; A.A. Vinogradov; A.I. Komarov; G.L. Karetnikov; N.V. Zyk; T. Holt; A.G. Kutateladze

Tetrahedron, 75, 2861-2865 (2019)

"Site-Selective Cysteine–Cyclooctyne Conjugation."

C. Zhang; P. Dai; A.A. Vinogradov; Z.P. Gates; B.L. Pentelute

Angew. Chem. Int. Ed., 57, 6459-6463 (2018)

"Xenoprotein engineering via synthetic libraries."

Z.P. Gates; A.A. Vinogradov; A.J. Quartararo; A. Bandyopadhyay; Z.-N. Choo; E.D. Evans; K.H. Halloran; A.J. Mijalis; S.K. Mong; M.D. Simon; E.A. Standley; E.D. Styduhar; S.Z. Tasker; F. Touti; J.M. Weber; J.L. Wilson; T.F. Jamison; B.L. Pentelute

Proceedings of the National Academy of Sciences, 115, E5298-E5306 (2018)

"Library Design-Facilitated High-Throughput Sequencing of Synthetic Peptide Libraries."

A.A. Vinogradov; Z.P. Gates; C. Zhang; A.J. Quartararo; K.H. Halloran; B.L. Pentelute

ACS Combinatorial Science, 19, 694-701 (2017)

"C-Terminal Modification of Fully Unprotected Peptide Hydrazides via in Situ Generation of Isocyanates."

A.A. Vinogradov; M.D. Simon; B.L. Pentelute

Organic Letters, 18, 1222-1225 (2016)

"Macrocyclization of Unprotected Peptide Isocyanates."

A.A. Vinogradov; Z.N. Choo; K.A. Totaro; B.L. Pentelute

Organic Letters, 18, 1226-1229 (2016)

"D -Amino Acid Scan of Two Small Proteins."

M.D. Simon; Y. Maki; A.A. Vinogradov; C. Zhang; H. Yu; Y.S. Lin; Y. Kajihara; B.L. Pentelute

Journal of the American Chemical Society, 138, 12099-12111 (2016)

"Synthesis of 5-fluoro- and 5-bromoalkylisoxazoles via nitrosation of 1,1-dihalocyclopropanes with sulfur trioxide activated nitrosyl chloride."

O.B. Bondarenko; A.A. Vinogradov; A.I. Komarov; A.S. Smirnov; N.V. Zyk

Journal of Fluorine Chemistry, 185, 201-205 (2016)

"Total synthesis and biochemical characterization of mirror image barnase."

A.A. Vinogradov; E.D. Evans; B.L. Pentelute

Chemical Science, 6, 2997-3002 (2015)

"Nitrosation of 2-aryl-1,1-dibromocyclopropanes: Synthesis of 3-aryl-5-bromoisoxazoles."

O.B. Bondarenko; A.A. Vinogradov; P.A. Danilov; S.N. Nikolaeva; A.Y. Gavrilova; N.V. Zyk

Tetrahedron Letters, 56, 6577-6579 (2015)

"Rapid flow-based peptide synthesis."

M.D. Simon; P.L. Heider; A. Adamo; A.A. Vinogradov; S.K. Mong; X. Li; T. Berger; R.L. Policarpo; C. Zhang; Y. Zou; X. Liao; A.M. Spokoyny; K.F. Jensen; B.L. Pentelute

ChemBioChem, 15, 713-720 (2014)

"Rapid total synthesis of DARPin pE59 and barnase."

S.K. Mong; A.A. Vinogradov; M.D. Simon; B.L. Pentelute

ChemBioChem, 15, 721-733 (2014)

"New anion-conducting solid solutions Bi1-xTex(O,F)2+δ (x > 0.5) and glass-ceramic material on their base."

V.A. Prituzhalov; E.I. Ardashnikova; A.A. Vinogradov; V.A. Dolgikh; J.J. Videau; E. Fargin; A.M. Abakumov; N.V. Tarakina; G. Van Tendeloo

Journal of Fluorine Chemistry, 132, 1110-1116 (2011)

Contact info

• • E-mail… a_vin"at"chem.s.u-tokyo.ac.jp (change "at" to @)