HELDZasshikai seminar 1964th, Professor Yan Zhang, “Photo-controllable bioorthogonal reactions and biomolecules”
Dec.23
- DATE&TIME
- 2024/12/23 16:00〜
- PLACE
- 3F Lecture room, Chemistry Main Bldg.
- SPEAKER
- Professor Yan Zhang, Nanjing University, China
- TITLE
- “Photo-controllable bioorthogonal reactions and biomolecules”
- HOST
- Prof. Takeaki Ozawa (ext.24351), Department of Chemistry, Graduate School of Science
Abstract: The establishment of bioorthogonal reaction made it possible for in situ labeling of biomolecules in living systems, which was considered as a milestone in the field of chemical biology. Photo-controllable bioorthogonal reactions add spatial-temporal resolution to bioorthogonal reactions and provide photo-controllable molecular tools in chemical biological studies. To realize photo-control on bioorthogonal reactions, we proposed and realized the photo-excited states involved bioorthogonal bond-formation approach. Based on this unique strategy, we established the visible-light driven bioorthogonal DVPC reaction and realized spatial-temporal labeling of live cells. We also established the first anionic cycloaddend-promoted bioorthogonal cycloaddition reaction. Based on bioorthogonal tool box, we have developed a diverse of photo-controllable bio-functional systems, including photo-activatable PROTAC, photo-controllable siRNA, and so on. I’ll present our recent work in the above-mentioned field in my talk, as well as a brief introduction to ChemBIC that is a multi-disciplinary research center at Nanjing University to promote chemistry-related biomedical innovation.
Speaker Biography
Yan Zhang got her Ph.D in 2002 from Nanjing University, China. She worked as postdoctoral research associate in Hong Kong University of Science and Technology from 2002 to 2004. In 2004-2006, she worked as postdoctoral fellow at the medical school of Stanford University. She joined Nanjing University in the September of 2006 as a professor and has begun her independent research in the field of optochemical biology since then. Her main research interest is the development of photo-driven bioorthogonal reactions and biological applications of photo-sensitive probes. She is now the vice dean of the school of chemistry and chemical engineering of Nanjing University.
