Publication List (2021)

Development of Chiral Potassium Strong Brønsted Base Catalysts for Enantioselective Carbon–Carbon Bond-Forming Reactions

Y. Yamashita*

Chem. Commun., accepted, (2022). DOI: 10.1039/D1CC06328F


Enantioselective Hydrophosphonylation of N-Boc Imines using Chiral Guanidine–Thiourea Catalysts

L. Chassillan, Y. Yamashita, W.-J. Yoo, M. Toffano, R. Guillot, S. Kobayashi*, G. Vo-Thanh*

Org. Biomol. Chem., 19, 10560-10564 (2021). DOI: 10.1039/D1OB01953H


Aerobic Oxidation of Alcohols Enabled by Nitrogen-Doped Copper Nanoparticle Catalysts

F. Tobita, T. Yasukawa*, Y. Yamashita, S. Kobayashi*

Catal. Sci. Technol., Accepted, (2021). DOI: 10.1039/D1CY01777B


Silica–Polystyrene Hybrid Core/Shell Microparticles of Rhodium–Chiral Diene Complexes as Catalysts for Asymmetric 1,4-Addition Reactions

T. Kuremoto, R. Sadatsune, T. Yasukawa, S. Kobayashi

ACS Catal., 11, 14026-14031 (2021). DOI: 10.1021/acscatal.1c04539


10 Continuous flow catalysis

H. Ishitani, S. Kobayashi

Volume 1 Flow Chemistry – Fundamentals, 335-378 (2021). DOI: 10.1515/9783110693676-010


Chiral Heterogeneous Scandium Lewis Acid Catalysts for Continuous-Flow Enantioselective Friedel–Crafts Carbon–Carbon Bond-Forming Reactions

Y. Saito, S. Kobayashi*

Angew. Chem. Int. Ed., 60, 26566-26570 (2021). DOI: 10.1002/anie.202112797


Aerobic Dehydrogenative Coupling of Naphthols and Phenols with a Ru(OH)x/Al2O3 Catalyst under Continuous-Flow Conditions

K. Masuda, W. Chen, K. Hayashi, S. Shimada, S. Onozawa,* N. Koumura, K. Sato, S. Kobayashi*

ChemistrySelect, 6, 10106-10110 (2021). DOI: 10.1002/slct.202102938


Development of Trifluoromethanesulfonic Acid-Immobilized Nitrogen-Doped Carbon-Incarcerated Niobia Nanoparticle Catalysts for Friedel–Crafts Acylation

X. Yang, T. Yasukawa*, Y. Yamashita, S. Kobayashi*

J. Org. Chem., 86, 15800-15806 (2021). DOI: 10.1021/acs.joc.1c01944


Two-Step Continuous-Flow Synthesis of Fungicide Metalaxyl through Catalytic C–N Bond-Formation Processes

H. Ishitani*, Z. Yu, T. Ichitsuka, N. Koumura, S. Onozawa, K. Sato, S. Kobayashi*

Adv. Synth. Catal., Accepted, (2021). DOI: 10.1002/adsc.202100898


Recent Advances of Asymmetric Catalysis in Flow for Drug Discovery

Y. Saito, S. Kobayashi*

Top. Med. Chem., 38, 173-222 (2021). DOI: 10.1007/7355_2021_128


Translation of Batch to Continuous Flow in Photoredox Reactions

T. Yasukawa, S. Kobayashi

ACS Cent. Sci., 7, 1099-1101 (2021). DOI: 10.1021/acscentsci.1c00711


Olefination of Aldehydes with Ethyl Diazoacetate Catalyzed by Nitrogen-Doped Carbon-Supported Metal

T. Yasukawa*, S. Kume, Y. Yamashita, S. Kobayashi*

Chem. Lett., 50, 1733-1735 (2021). DOI: 10.1246/cl.210355


α-Alkylation of Ketones with Alkenes Enabled by Photoinduced Activation of Silyl Enol Ethers in the Presence of a Small Amount of Water

T. Hirata, Y. Ogasawara, Y. Yamashita*, S. Kobayashi*

Org. Lett., 23, 5693-5697 (2021). DOI: 10.1021/acs.orglett.1c01824


Development of highly efficient Friedel–Crafts alkylations with alcohols using heterogeneous catalysts under continuous-flow conditions

K. Masuda*, Y. Okamoto, S. Onozawa, N. Koumura, S. Kobayashi*

RSC Adv., 11, 24424-24428 (2021). DOI: 10.1039/D1RA04005G


Machine-Assisted Preparation of a Chiral Diamine Ligand Library and In Silico Screening using Ab Initio Structural Parameters for Heterogeneous Chiral Catalysts

T. Kuremoto, R. Sadatsune, T. Yasukawa, Y. Yamashita, S. Kobayashi*

Adv. Synth. Catal., 363, 4202-4208 (2021). DOI: 10.1002/adsc.202100798


Sequential Continuous-Flow Synthesis of 3-Aryl Benzofuranones

H.-L. Xin, X. Rao, H. Ishitani*, S. Kobayashi*

Chem. Asian J., 16, 1906-1910 (2021). DOI: 10.1002/asia.202100461


Stereoretentive N‐Arylation of Amino Acid Esters with Cyclohexanones Utilizing a Continuous‐Flow System

T. Ichitsuka*, S. Komatsuzaki, K. Masuda, N. Koumura*, K. Sato, S. Kobayashi*

Chem. Eur. J., 27, 10844-10848 (2021). DOI: 10.1002/chem.202101439


Zeolite Catalysis Enables Efficient Pyrazinone Synthesis in Water

T. Hisada, T. Kitanosono*, Y. Yamashita, S. Kobayashi*

Bull. Chem. Soc. Jpn., 94, 1757-1759 (2021). DOI: 10.1246/bcsj.20210112


Synthetic Organic “Aquachemistry” that Relies on Neither Cosolvents nor Surfactants

T. Kitanosono, S. Kobayashi*

ACS Cent. Sci., 7, 739-747 (2021). DOI: 10.1021/acscentsci.1c00045


Chiral Metal Salts as Ligands for Catalytic Asymmetric Mannich Reactions with Simple Amides

Y. Yamashita,* A. Noguchi, S. Fushimi, M. Hatanaka, S. Kobayashi*

J. Am. Chem. Soc., 143, 5598-5604 (2021). DOI: 10.1021/jacs.0c13317


Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts

T. Hirata, I. Sato, Y. Yamashita,* S. Kobayashi*

Commun. Chem., 4, 36 (2021). DOI: 10.1038/s42004-021-00459-5


Nitrogen‐Doped Carbon Enables Heterogeneous Asymmetric Insertion of Carbenoids into Amines Catalyzed by Rhodium Nanoparticles

R. Masuda, T. Yasukawa,* Y. Yamashita, S. Kobayashi*

Angew. Chem., Int. Ed., 60, 12786-12790 (2021). DOI: 10.1002/anie.202102506


Highly Enantioselective Immobilized Prolinamide-Catalyzed Aldol Reactions in Continuous-Flow Systems: Effect of Water on Catalyst Lifetime and Application to the Synthesis of a Chiral Fenpentadiol Analogue

C. Yue, Y. Yamashita,* S. Kobayashi*

Green Chem., 23, 1989-1994 (2021). DOI: 10.1039/D0GC04202A


Zirconium Oxide‐Catalyzed Direct Amidation of Unactivated Esters under Continuous‐Flow Conditions

M. N. Rashed, K. Masuda, T. Ichitsuka, N. Koumura,* K. Sato,* S. Kobayashi*

Adv. Synth. Catal., 363, 2529-2535 (2021). DOI: 10.1002/adsc.202001496


Pt-Catalyzed selective oxidation of alcohols to aldehydes with hydrogen peroxide using continuous flow reactors

Y. Kon*, T. Nakashima, A. Yada, T. Fujitani, S. Onozawa, S. Kobayashi*, K. Sato*

Org. Biomol. Chem., 19, 1115-1121 (2021). DOI: 10.1039/D0OB02213F


High-Throughput Synthesis of (S)-α-Phellandrene through Three-Step Sequential Continuous-Flow Reactions

S. J. Miller, H. Ishitani*, Y. Furiya, S. Kobayashi*

Org. Process Res. Dev., 25, 192-198 (2021). DOI: 10.1021/acs.oprd.0c00391


Well‐Dispersed Trifluoromethanesulfonic Acid‐Treated Metal Oxide Nanoparticles Immobilized on Nitrogen‐Doped Carbon as Catalysts for Friedel–Crafts Acylation

X. Yang, T. Yasukawa*, T. Maki, Y. Yamashita, S. Kobayashi*

Chem. Asian J., 16, 232-236 (2021). DOI: 10.1002/asia.202001274


Hydrogen‐Bonding‐Assisted Cationic Aqua Palladium(II) Complex Enables Highly Efficient Asymmetric Reactions in Water

T. Kitanosono*, T. Hisada, Y. Yamashita, S. Kobayashi*

Angew. Chem., Int. Ed., 60, 3407-3411 (2021). DOI: 10.1002/anie.202009989


New Dimensions of Brønsted Base Catalyzed Carbon–Carbon Bond-Forming Reactions

Y. Yamashita*, S. Kobayashi*

Synlett, 32, 14-22 (2021). DOI: 10.1055/s-0040-1707202


Carbonylative Suzuki–Miyaura Coupling Reactions of Aryl Iodides with Readily Available Polymer-Immobilized Palladium Nanoparticles

T. Yasukawa*, Z. Zhu, Y. Yamashita, S. Kobayashi*

Synlett, 32, 502-504 (2021). DOI: 10.1055/s-0040-1707243