We use protein engineering to invent new tools for imaging dynamic biochemical events in live cells and tissues. We distribute these tools to cell biologists and neuroscientists who apply them to address questions ranging from fundamental mechanisms in cell biology, to the underlying causes of mental illness, to the development of novel therapeutics.




The molecules that make our work possible are colourful naturally occurring fluorescent proteins from jellyfish, coral, and other marine organisms. Starting from the gene for a fluorescent protein, we use the techniques of molecular biology, protein engineering, and artificial molecular evolution to create useful research tools. Since these tools are protein based, the instructions to make them can be easily introduced into cells, tissues, or even transgenic model organisms, in the form of DNA.


News / ニュース

A paper on new lactate sensor is published

We are delighted to announce that our paper titled “High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular L-Lactate” is now published in ACS Central Science. Congratulations to Saaya, Giang, and all co-authors! The paper can be accessed here.

針尾さん、Leさんらによる細胞内乳酸検出センサーに関する論文 (High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular L-Lactate) が ACS Central Science誌に発表されました。論文はこちらから。

Saaya received the presentation award in the Biophysical Society of Japan

Saaya received the student presentation award from the Biophysical Society of Japan for her excellent presentation at the 2023 conference. Congratulations!!!


Some members obtained degrees!

Congratulations, Youngjae, for a Bachelor’s, and Michael and Amanda, for their Master’s degree!



Kenwa received the poster prize in a summer school

Kenwa received the poster prize from the Devision of Biofunctional Chemistary, The Chemical Society of Japan for his excellent poster presentation in a summer school. Congratulations!!!


Social / ソーシャルメディア