We use protein engineering to invent new tools for imaging dynamic biochemical events in live cells and tissues. We distribute these tools to cell biologists and neuroscientists who apply them to address questions ranging from fundamental mechanisms in cell biology, to the underlying causes of mental illness, to the development of novel therapeutics.




The molecules that make our work possible are colourful naturally occurring fluorescent proteins from jellyfish, coral, and other marine organisms. Starting from the gene for a fluorescent protein, we use the techniques of molecular biology, protein engineering, and artificial molecular evolution to create useful research tools. Since these tools are protein based, the instructions to make them can be easily introduced into cells, tissues, or even transgenic model organisms, in the form of DNA.


News / ニュース

New members joined our lab!

We welcomed four undergraduate students (Yuuki, Miwa, Yuse, Rintato) and one Master’s student (Haruka) in April!


Ikumi won the Award of Excellence in FoPM Qualifying Exam

Ikumi received an Award of Excellence in the Qualifying Examination for the “Forefront Physics and Mathematics Program to Drive Transformation (FoPM)”!

宮崎さんが「変革を駆動する先端物理数学プログラム(FoPM)」のQualifying Examinationで優秀賞を受賞しました!

Some members obtained degrees!

Congratulations, Kenryo, for earning a Bachelor’s degree, and Takumi K, Shiori, Takumi Y, Kenwa, and Ikumi for their Master’s degree!


A paper on new lactate sensor is published

We are delighted to announce that our paper titled “High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular L-Lactate” is now published in ACS Central Science. Congratulations to Saaya, Giang, and all co-authors! The paper can be accessed here.

針尾さん、Leさんらによる細胞内乳酸検出センサーに関する論文 (High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular L-Lactate) が ACS Central Science誌に発表されました。論文はこちらから。

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