論文発表


2020年

"Discovery of quorum quenchers targeting the membrane-embedded sensor domain of theStaphylococcus aureusreceptor histidine kinase, AgrC."
Q. Xie; M.M. Wiedmann; A. Zhao; I.R. Pagan; R.P. Novick; H. Suga; T.W. Muir
Chemical communications, 56, 11223-11226 (2020)
"Ribosomal Elongation of Aminobenzoic Acid Derivatives."
T. Katoh; H. Suga
J Am Chem Soc, 142, 16518-16522 (2020)
"GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf."
Z. Zhang; R. Gao; Q. Hu; H. Peacock; D.M. Peacock; S. Dai; K.M. SHokat; H. Suga
ACS Cent. Sci., (2020)
"Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic beta-amino acids."
T. Katoh; T. Sengoku; K. Hirata; K. Ogata; H. Suga
Nature chemistry, (2020)
"Promiscuous Enzymes Cooperate at the Substrate Level En Route to Lactazole A."
A.A. Vinogradov; M. Shimomura; N. Kano; Y. Goto; H. Onaka; H. Suga
J Am Chem Soc, 142, 13886-13897 (2020)
"A Macrocyclic Peptide Library with a Structurally Constrained Cyclopropane-containing Building Block Leads to Thiol-independent Inhibitors of Phosphoglycerate Mutase."
R. Okuma; T. Kuwahara; T. Yoshikane; M. Watanabe; P. Dranchak; J. Inglese; S. Shuto; Y. Goto; H. Suga
Chemistry, an Asian journal, (2020)
"Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPalpha Interaction as a Potential Cancer Immunotherapy."
D. Hazama; Y. Yin; Y. Murata; M. Matsuda; T. Okamoto; D. Tanaka; N. Terasaka; J. Zhao; M. Sakamoto; Y. Kakuchi; Y. Saito; T. Kotani; Y. Nishimura; A. Nakagawa; H. Suga; T. Matozaki
Cell chemical biology, 27, 1181-1191 e1187 (2020)
"Minimal lactazole scaffold for in vitro thiopeptide bioengineering."
A.A. Vinogradov; M. Shimomura; Y. Goto; T. Ozaki; S. Asamizu; Y. Sugai; H. Suga; H. Onaka
Nat Commun, 11, 2272 (2020)
"Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display."
J. Johansen-Leete; T. Passioura; S. Foster; R.P. Bhusal; D. Ford; M. Liu; S.A.K. Jongkees; H. Suga; M.J. Stone; R.J. Payne
J Am Chem Soc, (2020)
"Design, Synthesis, and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents."
K. Koike; M. Nagano; M. Ebihara; T. Hirayama; M. Tsuji; H. Suga; H. Nagasawa
J Med Chem, 63, 4022-4046 (2020)
"Initiating ribosomal peptide synthesis with exotic building blocks."
C. Tsiamantas; J.M. Rogers; H. Suga
Chem Commun, 56, 4265-4272 (2020)
"Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a."
M.E. Otero-Ramirez; K. Matoba; E. Mihara; T. Passioura; J. Takagi; H. Suga
RSC Chem Biol, 1, 26-34 (2020)
"An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch."
S. Ishida; N. Terasaka; T. Katoh; H. Suga
Nat Chem Biol, (2020)
"Ribosomal Elongation of Cyclic γ-Amino Acids using a Reprogrammed Genetic Code."
T. Katoh; H. Suga
J Am Chem Soc, 142, 4965-4969 (2020)
"Exploring the Post-Translational Enzymology of PaaA by mRNA Display."
S.R. Fleming; P.M. Himes; S.V. Ghodge; Y. Goto; H. Suga; A.A. Bowers
J Am Chem Soc, 142, 5024-5028 (2020)
"Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-linked Diubiquitin by a Twofold Strategy."
H. Suga; A. Brik; Y. Huang; M. Nawatha
Chem Eur J, (2020)
"Improved Stability of siRNA-Loaded Lipid Nanoparticles Prepared with a PEG-Monoacyl Fatty Acid Facilitates Ligand-Mediated siRNA Delivery."
Y. Sakurai; W. Mizumura; K. Ito; K. Iwasaki; T. Katoh; Y. Goto; H. Suga; H. Harashima
Mol Pharm, 17, 1397-1404 (2020)
"Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages."
C. Tsiamantas; S. Kwon; J.M. Rogers; C. Douat; I. Huc; H. Suga
Angew Chem Int Edit, 59, 4860-4864 (2020)

2019年

"Ribosomal Formation of Thioamide Bonds in Polypeptide Synthesis."
R. Maini; H. Kimura; R. Takatsuji; T. Katoh; Y. Goto; H. Suga
J Am Chem Soc, 141, 20004-20008 (2019)
"De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor."
Y. Yin; N. Ochi; T.W. Craven; D. Baker; N. Takigawa; H. Suga
J Am Chem Soc, 141, 19193-19197 (2019)
"Minimal lactazole scaffold for in vitro production of pseudo-natural thiopeptides."
A.A. Vinogradov; M. Shimomura; Y. Goto; T. Ozaki; S. Asamizu; Y. Sugai; H. Suga; H. Onaka
bioRxiv, (2019)
"Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes."
K. Patel; L.J. Walport; J.L. Walshe; P. Solomon; K.K.J. Low; D.H. Tran; K.S. Mouradian; A.P.G. Silva; L. Wilkinson-White; J.M. Matthews; J.M. Guss; R.J. Payne; T. Passioura; H. Suga; M.J. P.
bioRxiv, (2019)
"Chemoenzymatic Posttranslational Modification Reactions for the Synthesis of Ψ[CH2NH]-Containing Peptides."
Y. Kato; T. Kuroda; Y. Huang; R. Ohta; Y. Goto; H. Suga
Angew Chem Int Edit, 59, 684-688 (2019)
"In Vitro Biosynthesis of Peptides Containing Exotic Azoline Analogues."
Y. Goto; H. Suga
Chembiochem, 21, 84-87 (2020)
"Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1."
S.T.P. Tran; C.J. Hipolito; H. Suzuki; R. Xie; H.D. Kim Tuyen; P.T. Dijke; N. Terasaka; Y. Goto; H. Suga; M. Kato
Biochem Biophys Res Commun, 516, 445-450 (2019)
"De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains."
M. Nawatha; J.M. Rogers; S.M. Bonn; I. Livneh; B. Lemma; S.M. Mali; G.B. Vamisetti; H. Sun; B. Bercovich; Y. Huang; A. Ciechanover; D. Fushman; H. Suga; A. Brik
Nature chemistry, 11, 644-652 (2019)
"A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display."
H. Hirose; T. Hideshima; T. Katoh; H. Suga
Chembiochem, 20, 2089-2100 (2019)
"Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation."
C. Tsiamantas; S. Kwon; C. Douat; I. Huc; H. Suga
Chemical communications, 55, 7366-7369 (2019)
"Discovery of Functional Macrocyclic Peptides by Means of the RaPID System."
C. Tsiamantas; M.E. Otero-Ramirez; H. Suga
Methods Mol Biol, 2001, 299-315 (2019)
"Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor."
K. Sakai; T. Passioura; H. Sato; K. Ito; H. Furuhashi; M. Umitsu; J. Takagi; Y. Kato; H. Mukai; S. Warashina; M. Zouda; Y. Watanabe; S. Yano; M. Shibata; H. Suga; K. Matsumoto
Nature chemical biology, 15, 598-606 (2019)
"Exploring of minimal RNA substrate of flexizymes."
T. Fujino; T. Kondo; H. Suga; H. Murakami
Chembiochem, (2019)
"Engineering Translation Components Improve Incorporation of Exotic Amino Acids."
T. Katoh; H. Suga
International journal of molecular sciences, 20, (2019)
"Flexizyme-catalyzed synthesis of 3'-aminoacyl-NH-tRNAs."
T. Katoh; H. Suga
Nucleic Acids Res, 47, e54 (2019)
"Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges."
A.A. Vinogradov; Y. Yin; H. Suga
J Am Chem Soc, 141, 4167-4181 (2019)
"Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation."
Y. Yin; Q. Fei; W. Liu; Z. Li; H. Suga; C. Wu
Angewandte Chemie, 58, 4880-4885 (2019)
"Ribosomal Synthesis of Backbone-Cyclic Peptides Compatible with In Vitro Display."
R. Takatsuji; K. Shinbara; T. Katoh; Y. Goto; T. Passioura; R. Yajima; Y. Komatsu; H. Suga
J Am Chem Soc, 141, 2279-2287 (2019)
"De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease."
T.P. Christoph Nitsche, Paul Varava, Mithun C. Mahawaththa, Mila M. Leuthold, Christian D. Klein, Hiroaki Suga and Gottfried Otting
ACS Med. Chem. Lett., 10, 168-174 (2019)
"Flexizyme-enabled benchtop biosynthesis of thiopeptides."
S.R. Fleming; T.E. Bartges; A.A. Vinogradov; C.L. Kirkpatrick; Y. Goto; H. Suga; L.M. Hicks; A.A. Bowers
J Am Chem Soc, 141, 758-762 (2019)
"RNA Display Methods for the Discovery of Bioactive Macrocycles."
Y. Huang; M.M. Wiedmann; H. Suga
Chemical reviews, 119, 10360-10391 (2019)

2018年

"Structural Features and Binding Modes of Thioether-Cyclized Peptide Ligands."
M.E. Otero-Ramirez; T. Passioura; H. Suga
Biomedicines, 6, (2018)
"In vitro expression of genetically encoded non-standard peptides consisting of exotic amino acid building blocks."
H. Hirose; C. Tsiamantas; T. Katoh; H. Suga
Curr Opin Biotechnol, 58, 28-36 (2018)
"Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist."
W. Miao; K. Sakai; N. Ozawa; T. Nishiuchi; Y. Suzuki; K. Ito; T. Morioka; M. Umitsu; J. Takagi; H. Suga; K. Matsumoto
Scientific reports, 8, 16492 (2018)
"Pyrrole-Mediated Peptide Cyclization Identified through Genetically Reprogrammed Peptide Synthesis."
K.W. Decoene; W. Vannecke; T. Passioura; H. Suga; A. Madder
Biomedicines, 6, (2018)
"MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner."
W. Miao; K. Sakai; R. Imamura; K. Ito; H. Suga; T. Sakuma; T. Yamamoto; K. Matsumoto
International journal of molecular sciences, 19, (2018)
"Nonproteinogenic deep mutational scanning of linear and cyclic peptides."
J.M. Rogers; T. Passioura; H. Suga
Proc Natl Acad Sci U S A, 115, 10959-10964 (2018)
"Artificial In Vitro Biosynthesis Systems for the Development of Pseudo-Natural Products."
Y. Goto; H. Suga
B Chem Soc Jpn, 91, 410-419 (2018)
"Artificial Division of Codon Boxes for Expansion of the Amino Acid Repertoire of Ribosomal Polypeptide Synthesis."
Y. Iwane; T. Katoh; Y. Goto; H. Suga
Methods Mol Biol, 1728, 17-47 (2018)
"Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors."
T. Kusakizako; Y. Tanaka; C.J. Hipolito; H. Suga; O. Nureki
Methods Mol Biol, 1700, 37-57 (2018)
"De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry."
T. Passioura; K. Watashi; K. Fukano; S. Shimura; W. Saso; R. Morishita; Y. Ogasawara; Y. Tanaka; M. Mizokami; C. Sureau; H. Suga; T. Wakita
Cell chemical biology, 25, 906-+ (2018)
"Display Selection of Exotic Macrocyclic Peptides Expressed under a Radically Reprogrammed 23 Amino Acid Genetic Code."
T. Passioura; W. Liu; D. Dunkelmann; T. Higuchi; H. Suga
J Am Chem Soc, 140, 11551-11555 (2018)
"Engineering of RiPP pathways for the production of artificial peptides bearing various non-proteinogenic structures."
Y. Goto; H. Suga
Current opinion in chemical biology, 46, 82-90 (2018)
"Facile Synthesis of Dimeric Thioether-Macrocyclic Peptides with Antibody-like Affinity against Plexin-B1."
N.K. Bashiruddi; U. Matsunaga; M. Nagano; J. Takagi; H. Suga
Bioconjugate Chem, 29, 1847-1851 (2018)
"Genetic code expansion via integration of redundant amino acid assignment by finely tuning tRNA pools."
K. Tajima; T. Katoh; H. Suga
Current opinion in chemical biology, 46, 212-218 (2018)
"Max-Bergmann award lecture:A RaPID way to discover bioactive nonstandard peptides assisted by the flexizyme and FIT systems."
H. Suga
Journal of peptide science : an official publication of the European Peptide Society, 24, (2018)
"Non-competitive cyclic peptides for targeting enzyme-substrate complexes."
T.E. McAllister; T.L. Yeh; M.I. Abboud; I.K.H. Leung; E.S. Hookway; O.N.F. King; B. Bhushan; S.T. Williams; R.J. Hopkinson; M. Munzel; N.D. Loik; R. Chowdhury; U. Oppermann; T.D.W. Claridge; Y. Goto; H. Suga; C.J. Schofield; A. Kawamura
Chemical science, 9, 4569-4578 (2018)
"Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid alpha-aminobutyrate."
J.M. Bacusmo; A.B. Kuzmishin; W.A. Cantara; Y. Goto; H. Suga; K. Musier-Forsyth
RNA Biol, 15, 576-585 (2018)
"Ribosomal Incorporation of Consecutive beta-Amino Acids."
T. Katoh; H. Suga
J Am Chem Soc, 140, 12159-12167 (2018)
"Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids."
J.M. Rogers; S. Kwon; S.J. Dawson; P.K. Mandal; H. Suga; I. Huc
Nature chemistry, 10, 405-412 (2018)
"Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A."
T. Passioura; B. Bhushan; A. Tumber; A. Kawamura; H. Suga
Bioorganic & medicinal chemistry, 26, 1225-1231 (2018)
"Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity."
K. Nishio; R. Belle; T. Katoh; A. Kawamura; T. Sengoku; K. Hanada; N. Ohsawa; M. Shirouzu; S. Yokoyama; H. Suga
Chembiochem, 19, 979-985 (2018)
"tRNA engineering for manipulating genetic code."
T. Katoh; Y. Iwane; H. Suga
RNA Biology, 15, 453-460 (2018)

2017年

"Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation."
T. Katoh; Y. Iwane; H. Suga
Nucleic Acids Res, 45, 12601-12610 (2017)
"Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting."
Y. Sakurai; W. Mizumura; M. Murata; T. Hada; S. Yamamoto; K. Ito; K. Iwasaki; T. Katoh; Y. Goto; A. Takagi; M. Kohara; H. Suga; H. Harashima
Mol Pharm, 14, 3290-3298 (2017)
"Strategies for transitioning macrocyclic peptides to cell-permeable drug leads."
L.J. Walport; R. Obexer; H. Suga
Curr Opin Biotechnol, 48, 242-250 (2017)
"Conformational and chemical selection by a trans-acting editing domain."
E.M. Danhart; M. Bakhtina; W.A. Cantara; A.B. Kuzmishin; X. Ma; B.L. Sanford; O. Vargas-Rodriguez; M. Kosutic; Y. Goto; H. Suga; K. Nakanishi; R. Micura; M.P. Foster; K. Musier-Forsyth
Proc Natl Acad Sci U S A, 114, E6774-E6783 (2017)
"Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid alpha-aminobutyrate."
J.M. Bacusmo; A.B. Kuzmishin; W.A. Cantara; Y. Goto; H. Suga; K. Musier-Forsyth
RNA Biol, 1-10 (2017)
"tRNA engineering for manipulating genetic code."
T. Katoh; Y. Iwane; H. Suga
RNA Biol, 1-8 (2017)
"Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis."
B.S. Shin; T. Katoh; E. Gutierrez; J.R. Kim; H. Suga; T.E. Dever
Nucleic Acids Res, 45, 8392-8402 (2017)
"Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5."
X. Song; L.Y. Lu; T. Passioura; H. Suga
Org Biomol Chem, 15, 5155-5160 (2017)
"Highly selective inhibition of histone demethylases by de novo macrocyclic peptides."
A. Kawamura; M. Munzel; T. Kojima; C. Yapp; B. Bhushan; Y. Goto; A. Tumber; T. Katoh; O.N. King; T. Passioura; L.J. Walport; S.B. Hatch; S. Madden; S. Muller; P.E. Brennan; R. Chowdhury; R.J. Hopkinson; H. Suga; C.J. Schofield
Nature communications, 8, 14773 (2017)
"Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads."
R. Obexer; L.J. Walport; H. Suga
Current opinion in chemical biology, 38, 52-61 (2017)
"Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo."
T. Ozaki; K. Yamashita; Y. Goto; M. Shimomura; S. Hayashi; S. Asamizu; Y. Sugai; H. Ikeda; H. Suga; H. Onaka
Nature communications, 8, 14207 (2017)
"Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases."
H. Yu; P. Dranchak; Z. Li; R. MacArthur; M.S. Munson; N. Mehzabeen; N.J. Baird; K.P. Battalie; D. Ross; S. Lovell; C.K. Carlow; H. Suga; J. Inglese
Nature communications, 8, 14932 (2017)
"Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides."
S.A.K. Jongkees; S. Caner; C. Tysoe; G.D. Brayer; S.G. Withers; H. Suga
Cell chemical biology, 24, 381-390 (2017)
"Consecutive Elongation of D-Amino Acids in Translation."
T. Katoh; K. Tajima; H. Suga
Cell chemical biology, 24, 46-54 (2017)
"A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets."
T. Passioura; H. Suga
Chemical communications, 53, 1931-1940 (2017)
"In vivo targeting of c-Met using a non-standard macrocyclic peptide in gastric carcinoma."
D.W. Hwang; N. Bahng; K. Ito; S. Ha; M.Y. Kim; E. Lee; H. Suga; D.S. Lee
Cancer letters, 385, 144-149 (2017)
"A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains."
T. Amoh; K. Murakami; R. Kariyama; K. Hori; Y. Irie; D. Viducic; K. Hirota; J. Igarashi; H. Suga; H. Kumon; Y. Miyake
The Journal of Medical Investigation, 64, 101-109 (2017)
"Effects of an autoinducer analogue on antibiotic tolerance in Pseudomonas aeruginosa."
T. Amoh; K. Murakami; R. Kariyama; K. Hori; D. Viducic; K. Hirota; J. Igarashi; H. Suga; M.R. Parsek; H. Kumon; Y. Miyake
J Antimicrob Chemother, 72, 2230-2240 (2017)
"Identification of nonstandard macrocyclic peptide ligands through display screening."
R.D. Taylor; M. Rey-Carrizo; T. Passioura; H. Suga
Drug discovery today. Technologies, 26, 17-23 (2017)

2016年

"Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide."
Y. Matsunaga; N.K. Bashiruddin; Y. Kitago; J. Takagi; H. Suga
Cell chemical biology, 23, 1341-1350 (2016)
"DNA module platform for developing colorimetric aptamer sensors."
Y. Tomita; Y. Morita; H. Suga; D. Fujiwara
BioTechniques, 60, 285-292 (2016)
"Ribosome-mediated synthesis of natural product-like peptides via cell-free translation."
R. Maini; S. Umemoto; H. Suga
Current opinion in chemical biology, 34, 44-52 (2016)
"LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae."
T. Kusakizako; Y. Tanaka; C.J. Hipolito; T. Kuroda; R. Ishitani; H. Suga; O. Nureki
Acta crystallographica. Section F, Structural biology communications, 72, 552-557 (2016)
"Energetics of side-chain snorkeling in transmembrane helices probed by nonproteinogenic amino acids."
K. Ojemalm; T. Higuchi; P. Lara; E. Lindahl; H. Suga; G. von Heijne
Proc Natl Acad Sci U S A, 113, 10559-10564 (2016)
"A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX."
N. Terasaka; K. Futai; T. Katoh; H. Suga
RNA, 22, 1918-1928 (2016)
"A Post-translational Cyclodehydratase, PatD, Tolerates Sequence Variation in the C-terminal Region of Substrate Peptides."
Y. Goto; H. Suga
Chem Lett, 45, 1247-1249 (2016)
"Essential structural elements in tRNA(Pro) for EF-P-mediated alleviation of translation stalling."
T. Katoh; I. Wohlgemuth; M. Nagano; M.V. Rodnina; H. Suga
Nature communications, 7, (2016)
"tRid, an enabling method to isolate previously inaccessible small RNA fractions."
K. Futai; N. Terasaka; T. Katoh; H. Suga
Methods, 106, 105-111 (2016)
"Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes."
Y. Iwane; A. Hitomi; H. Murakami; T. Katoh; Y. Goto; H. Suga
Nature chemistry, 8, 317-325 (2016)
"Genetic Code Expansion by Degeneracy Reprogramming of Arginyl Codons."
K.B. Lee; C.Y. Hou; C.E. Kim; D.M. Kim; H. Suga; T.J. Kang
Chembiochem, 17, 1198-1201 (2016)
"Ribosomal Synthesis of Peptides with Multiple beta-Amino Acids."
T. Fujino; Y. Goto; H. Suga; H. Murakami
J Am Chem Soc, 138, 1962-1969 (2016)
"Characterization of the Stereochemical Configuration of Lanthionines Formed by the Lanthipeptide Synthetase GeoM."
N. Garg; Y. Goto; T. Chen; W.A. van der Donk
Biopolymers, 106, 834-842 (2016)
"Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor."
N. Bayo-Puxan; R. Rodriguez-Mias; M. Goldflam; M. Kotev; S. Ciudad; C.J. Hipolito; M. Varese; H. Suga; R. Campos-Olivas; X. Barril; V. Guallar; M. Teixido; J. Garcia; E. Giralt
Chemmedchem, 11, 928-939 (2016)
"The synthesis and structure of a dianionic species with a bond between pentacoordinated tin atoms: bonding properties of the tin-tin bond."
S. Tsukada; N.J. O'Brien; N. Kano; T. Kawashima; J.D. Guo; S. Nagase
Dalton T, 45, 19374-19379 (2016)

2015年

"A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM."
K. Iwasaki; Y. Goto; T. Katoh; T. Yamashita; S. Kaneko; H. Suga
J Mol Evol, 81, 210-217 (2015)
"Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming."
J.M. Rogers; H. Suga
Organic & Biomolecular Chemistry, 13, 9353-9363 (2015)
"Synthesis of fused tricyclic peptides using a reprogrammed translation system and chemical modification."
N.K. Bashiruddin; M. Nagano; H. Suga
Bioorg Chem, 61, 45-50 (2015)
"Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation."
Z.W. Liu; O. Vargas-Rodriguez; Y. Goto; E.M. Novoa; L.R. de Pouplana; H. Suga; K. Musier-Forsyth
P Natl Acad Sci USA, 112, 6027-6032 (2015)
"Recent Developments of Engineered Translational Machineries for the Incorporation of Non-Canonical Amino Acids into Polypeptides."
N. Terasaka; Y. Iwane; A.S. Geiermann; Y. Goto; H. Suga
International journal of molecular sciences, 16, 6513-6531 (2015)
"Artificial human Met agonists based on macrocycle scaffolds."
K. Ito; K. Sakai; Y. Suzuki; N. Ozawa; T. Hatta; T. Natsume; K. Matsumoto; H. Suga
Nature communications, 6, (2015)
"Ancestral AlaX Editing Enzymes for Control of Genetic Code Fidelity Are Not tRNA-specific."
E.M. Novoa; O. Vargas-Rodriguez; S. Lange; Y. Goto; H. Suga; K. Musier-Forsyth; L.R. de Pouplana
J Biol Chem, 290, 10495-10503 (2015)
"Selection-based discovery of macrocyclic peptides for the next generation therapeutics."
T. Morioka; N.D. Loik; C.J. Hipolito; Y. Goto; H. Suga
Current opinion in chemical biology, 26, 34-41 (2015)
"Oxidative Bond Cleavage of the Silicon-Silicon Bond of a Pentacoordinated Disilicate."
N. Kano; H. Miyake; K. Sasaki; T. Kawashima
Heteroatom Chem, 26, 183-186 (2015)
"Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies."
N.K. Bashiruddin; H. Suga
Current opinion in chemical biology, 24, 131-138 (2015)
"Interconversion among Dianionic, Anionic, and Neutral Compounds Bearing a Bond between Two Pentacoordinated Germanium Atoms."
N. Kano; S. Tsukada; Y. Shibata; T. Kawashima; H. Sato; J.D. Guo; S. Nagase
Organometallics, 34, 56-62 (2015)
"2,2 '-Disilylazobenzenes featuring double intramolecular nitrogen center dot center dot center dot silicon coordination: a photoisomerizable fluorophore."
N. Kano; M. Yamamura; T. Kawashima
Dalton T, 44, 16256-16265 (2015)
"Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies."
N.K. Bashiruddin; H. Suga
Current opinion in chemical biology, 24, 131-138 (2015)

2014年

"Reprogramming the genetic code in vitro."
T. Passioura; H. Suga
Trends in biochemical sciences, 39, 400-408 (2014)
"Ribosomal synthesis of an amphotericin-B inspired macrocycle."
K. Torikai; H. Suga
J Am Chem Soc, 136, 17359-17361 (2014)
"Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution."
B.J. Desai; Y. Goto; A. Cembran; A.A. Fedorov; S.C. Almo; J. Gao; H. Suga; J.A. Gerlt
Proc Natl Acad Sci U S A, 111, 15066-15071 (2014)
"ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway."
S. Adachi; M. Homoto; R. Tanaka; Y. Hioki; H. Murakami; H. Suga; M. Matsumoto; K.I. Nakayama; T. Hatta; S. Iemura; T. Natsume
Nucleic Acids Res, 42, 10037-10049 (2014)
"Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans."
K. Kumazaki; T. Tsukazaki; T. Nishizawa; Y. Tanaka; H.E. Kato; Y. Nakada-Nakura; K. Hirata; Y. Mori; H. Suga; N. Dohmae; R. Ishitani; O. Nureki
Acta crystallographica. Section F, Structural biology communications, 70, 1056-1060 (2014)
"Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity."
R. Watanabe; N. Soga; D. Fujita; K.V. Tabata; L. Yamauchi; S. Hyeon Kim; D. Asanuma; M. Kamiya; Y. Urano; H. Suga; H. Noji
Nature communications, 5, 4519 (2014)
"An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center."
N. Terasaka; G. Hayashi; T. Katoh; H. Suga
Nat Chem Biol, 10, 555-557 (2014)
"One-pot synthesis of azoline-containing peptides in a cell-free translation system integrated with a posttranslational cyclodehydratase."
Y. Goto; Y. Ito; Y. Kato; S. Tsunoda; H. Suga
Chemistry & biology, 21, 766-774 (2014)
"Flexizymes-facilitated Genetic Code Reprogramming Leading to the Discovery of Drug-like Peptides."
N. Terasaka; H. Suga
Chem Lett, 43, 11-19 (2014)
"Protein cocrystallization molecules originating from in vitro selected macrocyclic peptides."
C.J. Hipolito; N.K. Bashiruddin; H. Suga
Current opinion in structural biology, 26, 24-31 (2014)
"Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets."
T. Shimada; K. Shimada; M. Matsui; Y. Kitai; J. Igarashi; H. Suga; A. Ishihama
Genes to cells : devoted to molecular & cellular mechanisms, 19, 405-418 (2014)
"Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog."
A. Kodan; T. Yamaguchi; T. Nakatsu; K. Sakiyama; C.J. Hipolito; A. Fujioka; R. Hirokane; K. Ikeguchi; B. Watanabe; J. Hiratake; Y. Kimura; H. Suga; K. Ueda; H. Kato
Proc Natl Acad Sci U S A, 111, 4049-4054 (2014)
"Selection-based discovery of druglike macrocyclic peptides."
T. Passioura; T. Katoh; Y. Goto; H. Suga
Annual review of biochemistry, 83, 727-752 (2014)
"Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change."
K. Yamagata; Y. Goto; H. Nishimasu; J. Morimoto; R. Ishitani; N. Dohmae; N. Takeda; R. Nagai; I. Komuro; H. Suga; O. Nureki
Structure, 22, 345-352 (2014)
"Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation."
M. Das; O. Vargas-Rodriguez; Y. Goto; H. Suga; K. Musier-Forsyth
Nucleic Acids Res, 42, 3943-3953 (2014)
"Flexizymes, their evolutionary history and diverse utilities."
T. Passioura; H. Suga
Topics in current chemistry, 344, 331-345 (2014)
"Synthesis, Structure, and Thermolysis of Tetracoordinated 1λ4,2‐Selenazetidines Bearing Two Chiral Centers at the 3‐ and 4‐Positions."
Y. Daicho; N. Kano; M. Yukimoto; M. Minoura; T. Kawashima
Heteroatom Chem, 25, 492-499 (2014)
"Aziridine formation with retention of configuration from a pentacoordinated 1,2-thiazetidine bearing two chiral centers at the 3- and 4-positions."
Y. Daicho; Y. Watanabe; N. Kano; M. Yukimoto; M. Minoura; T. Kawashima
Bull. Chem. Soc. Jpn, 87, (2014)

2013年

"Nonstandard peptide expression under the genetic code consisting of reprogrammed dual sense codons."
Y. Goto; M. Iseki; A. Hitomi; H. Murakami; H. Suga
ACS chemical biology, 8, 2630-2634 (2013)
"A macrocyclic peptide that serves as a cocrystallization ligand and inhibits the function of a MATE family transporter."
C.J. Hipolito; Y. Tanaka; T. Katoh; O. Nureki; H. Suga
Molecules, 18, 10514-10530 (2013)
"Structural basis for the drug extrusion mechanism by a MATE multidrug transporter."
Y. Tanaka; C.J. Hipolito; A.D. Maturana; K. Ito; T. Kuroda; T. Higuchi; T. Katoh; H.E. Kato; M. Hattori; K. Kumazaki; T. Tsukazaki; R. Ishitani; H. Suga; O. Nureki
Nature, 496, 247-251 (2013)
"Flexizyme-mediated genetic reprogramming as a tool for noncanonical peptide synthesis and drug discovery."
T. Passioura; H. Suga
Chemistry, 19, 6530-6536 (2013)
"In vitro selection of multiple libraries created by genetic code reprogramming to discover macrocyclic peptides that antagonize VEGFR2 activity in living cells."
T. Kawakami; T. Ishizawa; T. Fujino; P.C. Reid; H. Suga; H. Murakami
ACS chemical biology, 8, 1205-1214 (2013)
"Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides."
K. Ito; T. Passioura; H. Suga
Molecules, 18, 3502-3528 (2013)
"Reevaluation of the D-amino acid compatibility with the elongation event in translation."
T. Fujino; Y. Goto; H. Suga; H. Murakami
J Am Chem Soc, 135, 1830-1837 (2013)
"Fluorescent azobenzenes and aromatic aldimines featuring an N-B interaction."
J. Yoshino; N. Kano; T. Kawashima
Dalton Trans, 42, 15826-15834 (2013)
"Synthesis of a phosphine imide bearing a hydrosilane moiety, and its water-driven reduction to a phosphine."
N. Kano; K. Yanaizumi; X. Meng; N. Havare; T. Kawashima
Chemical communications, 49, 10373-10375 (2013)

2012年

"Comparative evaluation of two cell-free protein synthesis systems derived from Escherichia coli for genetic code reprogramming."
K.B. Lee; H.C. Kim; D.M. Kim; T.J. Kang; H. Suga
Journal of biotechnology, 164, 330-335 (2012)
"Novel acridine-based N-acyl-homoserine lactone analogs induce endoreduplication in the human oral squamous carcinoma cell line SAS."
H. Chai; M. Hazawa; Y. Hosokawa; J. Igarashi; H. Suga; I. Kashiwakura
Biological & pharmaceutical bulletin, 35, 1257-1263 (2012)
"Ribosomal production and in vitro selection of natural product-like peptidomimetics: the FIT and RaPID systems."
C.J. Hipolito; H. Suga
Current opinion in chemical biology, 16, 196-203 (2012)
"Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation."
K. Iwasaki; Y. Goto; T. Katoh; H. Suga
Org Biomol Chem, 10, 5783-5786 (2012)
"Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2."
J. Morimoto; Y. Hayashi; H. Suga
Angewandte Chemie, 51, 3423-3427 (2012)
"In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors."
Y. Hayashi; J. Morimoto; H. Suga
ACS chemical biology, 7, 607-613 (2012)
"Flexizymes as a tRNA acylation tool facilitating genetic code reprogramming."
Y. Goto; H. Suga
Methods Mol Biol, 848, 465-478 (2012)
"Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers."
P.C. Reid; Y. Goto; T. Katoh; H. Suga
Methods Mol Biol, 805, 335-348 (2012)
"Control of the Equilibrium between 2-Phosphinoazobenzenes and Inner Phosphonium Salts by Heat, Solvent, Acid, and Photoirradiation."
M. Yamamura; N. Kano; T. Kawashima
Bull. Chem. Soc. Jpn, 85, 110-123 (2012)
"2,2'-Diborylazobenzenes with Double N-B Coordination: Control of Fluorescent Properties by Substituents and Redox Reactions."
N. Kano; A. Furuta; T. Kambe; J. Yoshino; Y. Shibata; T. Kawashima; N. Mizorogi; S. Nagase
European Journal of Inorganic Chemistry, 1584-1587 (2012)
"Synthesis and Properties of Water-soluble Fluorescent 2-Borylazobenzenes Bearing Ionic Functional Groups."
H. Itoi; T. Kambe; N. Kano; T. Kawashima
Inorganica Chimica Acta, 381, 117-123 (2012)
"Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562."
M. Hazawa; M. Kudo; T. Iwata; K. Saito; K. Takahashi; J. Igarashi; H. Suga; I. Kashiwakura
Investigational new drugs, 30, 862-869 (2012)
"Functional properties of synthetic N-acyl-L-homoserine lactone analogs of quorum-sensing gram-negative bacteria on the growth of human oral squamous carcinoma cells."
H. Chai; M. Hazawa; N. Shirai; J. Igarashi; K. Takahashi; Y. Hosokawa; H. Suga; I. Kashiwakura
Investigational new drugs, 30, 157-163 (2012)

2011年

"Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library."
Y. Yamagishi; I. Shoji; S. Miyagawa; T. Kawakami; T. Katoh; Y. Goto; H. Suga
Chemistry & biology, 18, 1562-1570 (2011)
"The RNA origin of transfer RNA aminoacylation and beyond."
H. Suga; G. Hayashi; N. Terasaka
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 366, 2959-2964 (2011)
"Ribosomal synthesis of backbone macrocyclic peptides."
T. Katoh; Y. Goto; M.S. Reza; H. Suga
Chemical communications, 47, 9946-9958 (2011)
"Flexizymes: their evolutionary history and the origin of catalytic function."
J. Morimoto; Y. Hayashi; K. Iwasaki; H. Suga
Accounts of chemical research, 44, 1359-1368 (2011)
"Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase."
J. Chung; E. Goo; S. Yu; O. Choi; J. Lee; J. Kim; H. Kim; J. Igarashi; H. Suga; J.S. Moon; I. Hwang; S. Rhee
Proc Natl Acad Sci U S A, 108, 12089-12094 (2011)
"Flexizymes for genetic code reprogramming."
Y. Goto; T. Katoh; H. Suga
Nature protocols, 6, 779-790 (2011)
"Formation of a Cyclic Bis(iminophosphorane) from a 2,2'-Bis(phosphino)azobenzene via N=N Bond Cleavage."
M. Yamamura; N. Kano; T. Kawashima
Heteroatom Chem, 22, 301-306 (2011)
"Isolation of a Metastable Geometrical Isomer of a Hexacoordinated Dihydrophosphate: Elucidation of Its Enhanced Reactivity in Umpolung of a Hydrogen Atom of Water."
H. Miyake; N. Kano; T. Kawashima
Inorganic Chemistry, 50, 9083-9089 (2011)
"Translation of a histone H3 tail as a model system for studying peptidyl-tRNA drop-off."
T.J. Kang; H. Suga
FEBS letters, 585, 2269-2274 (2011)
"Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum."
K. Ojemalm; T. Higuchi; Y. Jiang; U. Langel; I. Nilsson; S.H. White; H. Suga; G. von Heijne
Proc Natl Acad Sci U S A, 108, E359-364 (2011)
"Ribosomal synthesis of backbone-macrocyclic peptides containing gamma-amino acids."
Y. Ohshiro; E. Nakajima; Y. Goto; S. Fuse; T. Takahashi; T. Doi; H. Suga
Chembiochem, 12, 1183-1187 (2011)
"Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off."
T.J. Kang; Y. Hayashi; H. Suga
Angewandte Chemie, 50, 2159-2161 (2011)
"Custom synthesis of autoinducers and their analogues."
J. Igarashi; H. Suga
Methods Mol Biol, 692, 265-274 (2011)

2010年

"Ribosome evolution for two artificial amino acids in E. coli."
G. Hayashi; Y. Goto; H. Suga
Chemistry & biology, 17, 320-321 (2010)
"Engineering of the Redox Ribozyme for the Determination of Its Architecture."
S.B. Pattnaik; K. Jin; K. Futai; H. Suga
Chem Lett, 39, 786-787 (2010)

2009年

"Diverse backbone-cyclized peptides via codon reprogramming."
T. Kawakami; A. Ohta; M. Ohuchi; H. Ashigai; H. Murakami; H. Suga
Nat Chem Biol, 5, 888-890 (2009)
"A flexizyme that selectively charges amino acids activated by a water-friendly leaving group."
N. Niwa; Y. Yamagishi; H. Murakami; H. Suga
Bioorganic & medicinal chemistry letters, 19, 3892-3894 (2009)
"Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides."
Y. Goto; K. Iwasaki; K. Torikai; H. Murakami; H. Suga
Chemical communications, 3419-3421 (2009)
"Ribosomal synthesis of cyclic peptides with a fluorogenic oxidative coupling reaction."
Y. Yamagishi; H. Ashigai; Y. Goto; H. Murakami; H. Suga
Chembiochem, 10, 1469-1472 (2009)
"Ribosomal synthesis of peptides with C-terminal lactams, thiolactones, and alkylamides."
E. Nakajima; Y. Goto; Y. Sako; H. Murakami; H. Suga
Chembiochem, 10, 1186-1192 (2009)
"Translation initiation with initiator tRNA charged with exotic peptides."
Y. Goto; H. Suga
J Am Chem Soc, 131, 5040-5041 (2009)
"Bases in the anticodon loop of tRNA(Ala)(GGC) prevent misreading."
H. Murakami; A. Ohta; H. Suga
Nature structural & molecular biology, 16, 353-358 (2009)

2008年

"Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids."
T. Kawakami; H. Murakami; H. Suga
J Am Chem Soc, 130, 16861-16863 (2008)
"Expression of histone H3 tails with combinatorial lysine modifications under the reprogrammed genetic code for the investigation on epigenetic markers."
T.J. Kang; S. Yuzawa; H. Suga
Chemistry & biology, 15, 1166-1174 (2008)
"Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme."
H. Xiao; H. Murakami; H. Suga; A.R. Ferre-D'Amare
Nature, 454, 358-361 (2008)
"Initiating translation with D-amino acids."
Y. Goto; H. Murakami; H. Suga
Rna, 14, 1390-1398 (2008)
"Ribosomal synthesis of bicyclic peptides via two orthogonal inter-side-chain reactions."
Y. Sako; J. Morimoto; H. Murakami; H. Suga
J Am Chem Soc, 130, 7232-7234 (2008)
"Ribosomal synthesis of peptidase-resistant peptides closed by a nonreducible inter-side-chain bond."
Y. Sako; Y. Goto; H. Murakami; H. Suga
ACS chemical biology, 3, 241-249 (2008)
"Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides."
Y. Goto; A. Ohta; Y. Sako; Y. Yamagishi; H. Murakami; H. Suga
ACS chemical biology, 3, 120-129 (2008)
"Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides."
T. Kawakami; H. Murakami; H. Suga
Chemistry & biology, 15, 32-42 (2008)
"Ribosomal synthesis of nonstandard peptides."
T.J. Kang; H. Suga
Biochemistry and cell biology = Biochimie et biologie cellulaire, 86, 92-99 (2008)
"Polymerization of alpha-hydroxy acids by ribosomes."
A. Ohta; H. Murakami; H. Suga
Chembiochem, 9, 2773-2778 (2008)
"Synthesis of biopolymers using genetic code reprogramming."
A. Ohta; Y. Yamagishi; H. Suga
Current opinion in chemical biology, 12, 159-167 (2008)

2007年以前

"Electronic Excitation Energy Transfer in DNA. Nature of Triplet Excitations Capturing Centers"
V.M. Yashchuk, V. Y. Kudrya, M. Y. Losytskyy, I. Y. Dubey, H. Suga*
Molecular Crystals and Liquid Crystals 467, 311-323. (2007)
"Synthetic and Biological Functional Compounds with Direct Excitons Conductivity for Nanoelectronic Devices"
Valeriy M. Yashchuk; Vladislav Yu. Kudrya; Irina V. Savchenko; Grygoriy P. Golovach; Igor Ya. Dubey; Rostyslav D. Fedorovich; Hiroaki Suga; Juozas V. Grazulevicius
Molecular Crystals and Liquid Crystals, 1563-5287, Volume 468, 2007, Pages 275/[627] – 288/[640]
"Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump"
Y.Y. Chan, H.S. Bian, T.M. Tan, M.E. Mattmann, G.D. Geske, J. Igarashi, T. Hatano, H. Suga, H.E. Blackwell, K.L. Chua
Journal of Bacteriology 189, 4320-4324 (2007)
"Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae"
J. Kim, Y. Kang, O. Choi, Y. Jeong, J.E. Jeong, J.Y. Lim, M. Kim, J.S. Moon, H. Suga, I. Hwang
Molecular Microbiology 64, 165-179 (2007)
"N-(3-hydroxyhexanoyl)-l-homoserine lactone is the biologically relevant quormone that regulates the phz operon of Pseudomonas chlororaphis strain 30-84"
S. R. Khan, J. Herman, J. Krank, N. J. Serkova, M. E. Churchill, H. Suga, S. K. Farrand
Applied Environmental Microbiology 73(22), 7443-7455.(2007)
"Synthesis of polyester by means of genetic code reprogramming"
A. Ohta, H. Murakami, E. Higashimura, H. Suga*
Chemistry & Biology 14, 1315-1322 (2007)
"The flexizyme system: A highly flexible tRNA aminoacyation tool for the translation apparatus"
M. Ohuchi, H. Murakami, H. Suga*
Current Opinion in Chemical Biology 11, 135-144 (2007)
"The nature of the electronic excitations capturing centres in the DNA"
V.M. Yashchuk, V. Y. Kudrya, M. Y. Losytskyy, H. Suga, T. Ohul'chanskyy (2006)
Journal of Molecular Liquids 127, 79–83.
"Leucyl/Phenylalanyl-tRNA-protein transferase-mediated chemoenzymatic coupling of N-terminal Arg/Lys units in post-translationally processed proteins with non-natural amino acids"
Taki M, Kuno A, Matoba S, Kobayashi Y, Futami J, Murakami H, Suga H, Taira K, Hasegawa T, Sisido
M. ChemBioChem 7, 1676-1679 (2006).
"A highly flexible tRNA acylation method for nonnatural polypeptide synthesis"
H. Murakami, A. Ohta, H. Ashigai, H. Suga* (2006)
Nature Methods 3, 357-359.
"Stereoisomers of P. aeruginosa autoinducer Analog to probe the regulator binding site"
G. Jog, J. Igarashi, H. Suga* (2006)
Chemistry & Biology 13, 123-128.
"Activation of the phz operon of Pseudomonas fluorescens 2-79 requires the LuxR homolog PhzR, N-(3-OH-Hexanoyl)-L-homoserine lactone produced by the LuxI homolog PhzI, and a cis-acting phz box"
S.R. Khan, D.V. Mavrodi, G.J. Jog, H. Suga, L.S. Thomashow, S.K. Farrand (2005)
Journal of Bacteriology 187, 6517-6527.
"Programmable ribozymes for mischarging tRNA with nonnatural amino acids and their applications to translation"
D. Kourouklis, H. Murakami, H. Suga* (2005)
Methods, 36(3), 239-244.
"Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae"
J. Kim, J.-G. Kim, Y. Kang, J. Y. Jang, G. J. Jog, J. Y. Lim, S. Kim, H. Suga, T. Nagamatsu and I. Hwang (2004)
Molecular Microbiology 54, 921-934.
"Designer ribozymes: Programming tRNA specificity into Flexizyme"
K. Ramaswamy, H. Saito, H. Murakami, K. Shiba, H. Suga* (2004)
Journal of American Chemical Society 126, 11454-11455.
"Reduction of an aldehyde by a NADH/Zn2+-dependent redox active ribozyme"
S. Tsukiji, S. Pattnaik, H. Suga* (2004)
Journal of American Chemical Society 126, 5044-5045.
"Ribozymes that use redox cofactors"
S. Tsukiji, K. Ramaswamy, H. Suga* (2004)
Pure & Applied Chemistry 76, 1525-1536.
"Using a solid-phase ribozyme aminoacylation system to reprogram the genetic code"
H. Murakami, D. Kourouklis, H. Suga* (2003)
Chemistry & Biology 10, 1077-1084.
"An alcohol dehydrogenase ribozyme"
S. Tsukiji, S. B. Pattnaik, H. Suga* (2003) "
Nature Structural Biology 10, 713-717.
"A versatile tRNA aminoacylation catalyst based on RNA"
A H. Murakami, H. Saito, H. Suga* (2003)
Chemistry & Biology 10, 655-662
"Library screening for synthetic agonists and antagonists of Pseudomonas aeruginosa autoinudcer"
K. Smith, Y. Bu, H. Suga* (2003)
Chemistry & Biology 10, 563-571.
E "Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs"
K. Smith, Y. Bu, H. Suga* (2003)
Chemistry & Biology 10, 81-89.
"Molecular mechanisms of bacterial quorum sensing as a new drug target"
H. Suga* and K. M. Smith (2003)
Current Opinion in Chemical Biology 7, 589-591.
"Mechanistic studies on acyl transferase ribozymes and beyond"
D. Hodgson, H. Suga* (2003)
Biopolymers 10, 1077-1084.
"Outersphere and innersphere coordinated metal ions in an aminoacyl-tRNA synthetase ribozyme"
H. Saito, H. Suga* (2002)
Nucleic Acid Research 30, 5151-5159.
A "A tRNA aminoacylation system for non-natural amino acids based on a programmable ribozyme"
Y. Bessho, D. Hodgson, H. Suga* (2002)
Nature Biotechnology 20, 723-728.
"Aminoacyl-tRNA synthesis by a resin-immobilized ribozyme"
H. Murakami, N. J. Bonzagni, H. Suga* (2002)
Journal of American Chemical Society 124, 6834-6835.
"Minihelix-loop RNAs: Minimal structure for the emergence of a primitive aminoacylation system"
K. Ramaswarmy, K. Wei, H. Suga* (2002)
Nucleic Acid Research 30, 2162-2171.
"Recognition of Phosphate and Sugar Groups in tRNACys for Aminoacylation: Evolution from E. coli to Human"
X. Ming, K. Smith, H. Suga, and Y.-M. Hou (2002)
Journal of Molecular Biology 318, 1207-20.
"Concurrent molecular recognition of the amino acid and tRNA by a ribozyme"
H. Saito, K. Watanabe, H. Suga* (2001)
RNA 7,1867-1878.
"A single metal ion plays structural and chemical roles in an acyl-transferase ribozyme"
A. Flynn-Charlebois, N. Lee, H. Suga* (2001)
Biochemistry 40, 13623-13632.
"Essential roles of inner-sphere metal ions for the formation of the glutamine binding site in a bifunctional ribozyme"
N. Lee, H. Suga* (2001)
Biochemistry 40, 13633-13643.
"A ribozyme aminoacylates exclusively on the 3'-hydroxyl group of the 3'-terminus of tRNA"
H. Saito, H. Suga* (2001)
Journal of American Chemical Society 123, 7178-7179.
"Diverse roles of metal ions in acyl-transferase ribozymes"
A. Vaidya, H. Suga* (2001)
Biochemistry 40, 7200-7210.
"A mini-helix-loop RNA acts as a trans-acting aminoacylation catalyst"
N. Lee, H. Suga* (2001)
RNA 7, 1043-1051.
"An In vitro evolved precursor tRNA with aminoacylation activity"
H. Saito, D. Kourouklis, H. Suga* (2001)
EMBO Journal 20, 1797-1806.
"Ribozyme-catalyzed tRNA aminoacylation"
N. Lee, Y. Bessho, K. Wei, J.W. Szostak, H. Suga* (2000)
Nature Structural Biology 7, 28-34.
"Unusual Metal Ion Catalysis in an Acyl-Transferase Ribozyme"
H. Suga, J.A. Cowan, J.W. Szostak (1998)
Biochemistry 37, 10118-10125.
"The Secondary Structure and Essential Catalytic Features of an Acyl Transferase Ribozyme"
H. Suga, P.A. Lohse, J.W. Szostak (1998)
Journal of American Chemical Society 120, 1151-1156.
"Electrogeneration of Triphenyltin Radical, Anion, and Cation. Electrochemical Initiation of Tin Hydride-Promoted Radical Chain Reactions"
H. Tanaka, H. Ogawa, H. Suga, S. Torii, A. Jutand, S. Aziz, A.G. Suarez, C. Amatore
Journal of Organic
"Catalytic antibodies generated via homologous and heterologous immunization"
T. Tsumuraya, H. Suga, S. Meguro, A. Tsunakawa, S. Masamune (1995)
Journal of American Chemical Society 117, 11390-11396.
"Glycosidase antibodies induced to a half-chair transition-state analog"
H. Suga, N. Tanimoto, A.J. Sinskey, S. Masamune (1994)
Journal of American Chemical Society 116, 11197-11198.
"Catalytic antibodies generated via heterologous immunization"
H. Suga, O. Ersoy, S.F. Williams, T. Tsumuraya, M.N. Margolies, A.J. Sinskey, S. Masamune (1994)
Journal of American Chemical Society 116, 6025-6026.
"Catalytic antibodies generated via heterologous immunization"
H. Suga, O. Ersoy, T. Tsumuraya, J. Lee, A.J. Sinskey, S. Masamune (1994)
Journal of American Chemical Society 116, 487-494.
"Electrooxidative initiation of tin hydride-promoted radical chain reactions"
H. Tanaka, H. Suga, H. Ogawa, A.K.M. Abdul Hai, S. Torii, A. Jutand, C. Amatore (1992)
Tetrahedron Letters 33, 6495-6498.
"Vicinal bromofluoroalkanes: their regioselective formation and their conversion to fluoroolefins"
H. Suga, T. Hamatani, Y. Guggisberg, M. Schlosser (1990)
Tetrahedron 46, 4255-4260.
"α-Fluoro- and α,α-difluoroalkanals by substitution of vicinal bromofluoroalkanes and subsequent pummerer rearrangement"
H. Suga, M. Schlosser (1990)
Tetrahedron 46, 4261-4264.
"Regioselective formation of fluorohydrins and their stereoselective conversion to fluoroolefins"
H. Suga, T. Hamatani, M. Schlosser (1990)
Tetrahedron 46, 4247-4254.