"Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors."
T. Kusakizako; Y. Tanaka; C.J. Hipolito; H. Suga; O. Nureki
Methods Mol Biol, 1700, 37-57 (2018)
"Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation."
T. Katoh; Y. Iwane; H. Suga
Nucleic Acids Res, (2017)
"Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting."
Y. Sakurai; W. Mizumura; M. Murata; T. Hada; S. Yamamoto; K. Ito; K. Iwasaki; T. Katoh; Y. Goto; A. Takagi; M. Kohara; H. Suga; H. Harashima
Mol Pharm, 14, 3290-3298 (2017)
"Strategies for transitioning macrocyclic peptides to cell-permeable drug leads."
L.J. Walport; R. Obexer; H. Suga
Curr Opin Biotechnol, 48, 242-250 (2017)
"Conformational and chemical selection by a trans-acting editing domain."
E.M. Danhart; M. Bakhtina; W.A. Cantara; A.B. Kuzmishin; X. Ma; B.L. Sanford; M. Kosutic; Y. Goto; H. Suga; K. Nakanishi; R. Micura; M.P. Foster; K. Musier-Forsyth
Proc Natl Acad Sci U S A, 114, E6774-E6783 (2017)
"Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid alpha-aminobutyrate."
J.M. Bacusmo; A.B. Kuzmishin; W.A. Cantara; Y. Goto; H. Suga; K. Musier-Forsyth
RNA Biol, 1-10 (2017)
"tRNA engineering for manipulating genetic code."
T. Katoh; Y. Iwane; H. Suga
RNA Biol, 1-8 (2017)
"Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis."
B.S. Shin; T. Katoh; E. Gutierrez; J.R. Kim; H. Suga; T.E. Dever
Nucleic Acids Res, 45, 8392-8402 (2017)
"Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5."
X. Song; L.Y. Lu; T. Passioura; H. Suga
Org Biomol Chem, 15, 5155-5160 (2017)
"Highly selective inhibition of histone demethylases by de novo macrocyclic peptides."
A. Kawamura; M. Munzel; T. Kojima; C. Yapp; B. Bhushan; Y. Goto; A. Tumber; T. Katoh; O.N. King; T. Passioura; L.J. Walport; S.B. Hatch; S. Madden; S. Muller; P.E. Brennan; R. Chowdhury; R.J. Hopkinson; H. Suga; C.J. Schofield
Nature communications, 8, 14773 (2017)
"Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads."
R. Obexer; L.J. Walport; H. Suga
Current opinion in chemical biology, 38, 52-61 (2017)
"Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo."
T. Ozaki; K. Yamashita; Y. Goto; M. Shimomura; S. Hayashi; S. Asamizu; Y. Sugai; H. Ikeda; H. Suga; H. Onaka
Nature communications, 8, 14207 (2017)
"Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases."
H. Yu; P. Dranchak; Z. Li; R. MacArthur; M.S. Munson; N. Mehzabeen; N.J. Baird; K.P. Battalie; D. Ross; S. Lovell; C.K. Carlow; H. Suga; J. Inglese
Nature communications, 8, 14932 (2017)
"Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides."
S.A. Jongkees; S. Caner; C. Tysoe; G.D. Brayer; S.G. Withers; H. Suga
Cell chemical biology, 24, 381-390 (2017)
"Consecutive Elongation of D-Amino Acids in Translation."
T. Katoh; K. Tajima; H. Suga
Cell chemical biology, 24, 46-54 (2017)
"A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets."
T. Passioura; H. Suga
Chemical communications, (2017)
"In vivo targeting of c-Met using a non-standard macrocyclic peptide in gastric carcinoma."
D.W. Hwang; N. Bahng; K. Ito; S. Ha; M.Y. Kim; E. Lee; H. Suga; D.S. Lee
Cancer letters, 385, 144-149 (2017)
"A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains."
T. Amoh; K. Murakami; R. Kariyama; K. Hori; Y. Irie; D. Viducic; K. Hirota; J. Igarashi; H. Suga; H. Kumon; Y. Miyake
The journal of medical investigation : JMI, 64, 101-109 (2017)


"Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide."
Y. Matsunaga; N.K. Bashiruddin; Y. Kitago; J. Takagi; H. Suga
Cell chemical biology, 23, 1341-1350 (2016)
"DNA module platform for developing colorimetric aptamer sensors."
Y. Tomita; Y. Morita; H. Suga; D. Fujiwara
BioTechniques, 60, 285-292 (2016)
"Ribosome-mediated synthesis of natural product-like peptides via cell-free translation."
R. Maini; S. Umemoto; H. Suga
Current opinion in chemical biology, 34, 44-52 (2016)
"LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae."
T. Kusakizako; Y. Tanaka; C.J. Hipolito; T. Kuroda; R. Ishitani; H. Suga; O. Nureki
Acta crystallographica. Section F, Structural biology communications, 72, 552-557 (2016)
"Energetics of side-chain snorkeling in transmembrane helices probed by nonproteinogenic amino acids."
K. Ojemalm; T. Higuchi; P. Lara; E. Lindahl; H. Suga; G. von Heijne
Proceedings of the National Academy of Sciences of the United States of America, 113, 10559-10564 (2016)
"A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX."
N. Terasaka; K. Futai; T. Katoh; H. Suga
RNA, 22, 1918-1928 (2016)
"Essential structural elements in tRNA(Pro) for EF-P-mediated alleviation of translation stalling."
T. Katoh; I. Wohlgemuth; M. Nagano; M.V. Rodnina; H. Suga
Nature communications, 7, 11657 (2016)
"tRid, an enabling method to isolate previously inaccessible small RNA fractions."
K. Futai; N. Terasaka; T. Katoh; H. Suga
Methods, (2016)
"Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes."
Y. Iwane; A. Hitomi; H. Murakami; T. Katoh; Y. Goto; H. Suga
Nature chemistry, 8, 317-325 (2016)
"Genetic Code Expansion by Degeneracy Reprogramming of Arginyl Codons."
K.B. Lee; C.Y. Hou; C.E. Kim; D.M. Kim; H. Suga; T.J. Kang
Chembiochem : a European journal of chemical biology, (2016)
"Ribosomal Synthesis of Peptides with Multiple beta-Amino Acids."
T. Fujino; Y. Goto; H. Suga; H. Murakami
Journal of the American Chemical Society, 138, 1962-1969 (2016)
"Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM."
N. Garg; Y. Goto; T. Chen; W.A. van der Donk
Biopolymers, 106, 834-842 (2016)
"Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor."
N. Bayo-Puxan; R. Rodriguez-Mias; M. Goldflam; M. Kotev; S. Ciudad; C.J. Hipolito; M. Varese; H. Suga; R. Campos-Olivas; X. Barril; V. Guallar; M. Teixido; J. Garcia; E. Giralt
ChemMedChem, 11, 928-939 (2016)
"The synthesis and structure of a dianionic species with a bond between pentacoordinated tin atoms: bonding properties of the tin-tin bond."
S. Tsukada; N.J. O'Brien; N. Kano; T. Kawashima; J.D. Guo; S. Nagase
Dalton Trans, 45, 19374-19379 (2016)


"A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM."
K. Iwasaki; Y. Goto; T. Katoh; T. Yamashita; S. Kaneko; H. Suga
Journal of molecular evolution, 81, 210-217 (2015)
"Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming."
J.M. Rogers; H. Suga
Organic & biomolecular chemistry, 13, 9353-9363 (2015)
"Synthesis of fused tricyclic peptides using a reprogrammed translation system and chemical modification."
N.K. Bashiruddin; M. Nagano; H. Suga
Bioorganic chemistry, 61, 45-50 (2015)
"Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation."
Z. Liu; O. Vargas-Rodriguez; Y. Goto; E.M. Novoa; L. Ribas de Pouplana; H. Suga; K. Musier-Forsyth
Proceedings of the National Academy of Sciences of the United States of America, 112, 6027-6032 (2015)
"Recent developments of engineered translational machineries for the incorporation of non-canonical amino acids into polypeptides."
N. Terasaka; Y. Iwane; A.S. Geiermann; Y. Goto; H. Suga
International journal of molecular sciences, 16, 6513-6531 (2015)
"Artificial human Met agonists based on macrocycle scaffolds."
K. Ito; K. Sakai; Y. Suzuki; N. Ozawa; T. Hatta; T. Natsume; K. Matsumoto; H. Suga
Nature communications, 6, 6373 (2015)
"Ancestral AlaX Editing Enzymes for Control of Genetic Code Fidelity are not tRNA Specific."
E.M. Novoa; O. Vargas-Rodriguez; S. Lange; Y. Goto; H. Suga; K. Musier-Forsyth; L. Ribas de Pouplana
The Journal of biological chemistry, in press. (2015)
"Selection-based discovery of macrocyclic peptides for the next generation therapeutics."
T. Morioka; N.D. Loik; C.J. Hipolito; Y. Goto; H. Suga
Current opinion in chemical biology, 26C, 34-41 (2015)
"Oxidative Bond Cleavage of the Silicon-Silicon Bond of a Pentacoordinated Disilicate."
N. Kano; H. Miyake; K. Sasaki; T. Kawashima
Heteroat. Chem., 26, 183-186 (2015)
"Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies."
N.K. Bashiruddin; H. Suga
Current opinion in chemical biology, 24, 131-138 (2015)
"Interconversion among Dianionic, Anionic, and Neutral Compounds Bearing a Bond between Two Pentacoordinated Germanium Atoms."
N. Kano; S. Tsukada; Y. Shibata; T. Kawashima; H. Sato; J.-D. Guo; S. Nagase
Organometallics, 34, 56-62 (2015)
"2,2'-Disilylazobenzenes featuring double intramolecular nitrogensilicon coordination: a photoisomerizable fluorophore."
N. Kano; M. Yamamura; T. Kawashima
Dalton Trans, 44, 16256-16265 (2015)


"Reprogramming the genetic code in vitro."
T. Passioura; H. Suga
Trends in Biochemical Sciences 39, 400-408 (2014)
"Ribosomal synthesis of an amphotericin-B inspired macrocycle."
K. Torikai; H. Suga
Journal of the American Chemical Society, 136, 17359-17361 (2014)
"Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution."
B.J. Desai; Y. Goto; A. Cembran; A.A. Fedorov; S.C. Almo; J. Gao; H. Suga; J.A. Gerlt
Proceedings of the National Academy of Sciences USA, 111, 15066-15071 (2014)
"Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies."
N.K. Bashiruddin; H. Suga
Current Opinion in Chemical Biology 24C, 131-138 (2014)
"ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway."
S. Adachi; M. Homoto; R. Tanaka; Y. Hioki; H. Murakami; H. Suga; M. Matsumoto; K.I. Nakayama; T. Hatta; S. Iemura; T. Natsume
Nucleic Acids Research 42, 10037-10049 (2014)
"Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans."
K. Kumazaki, T. Tsukazaki, T. Nishizawa, Y. Tanaka, H.E. Kato, Y. Nakada-Nakura, K. Hirata, Y. Mori, H. Suga, N. Dohmae, R. Ishitani, O. Nureki*
Acta Crystallographica Section F Structural Biology Communications, F70, 1056-1060 (2014)
"Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity."
R. Watanabe*, N. Soga, D. Fujita, K.V. Tabata, L. Yamauchi, K.S. Hyeon, D. Asanuma, M. Kamiya, Y. Urano, H. Suga*, H. Noji*
Nature Communications, 5, 4519(2014)
"An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center."
N. Terasaka, G. Hayashi, T. Katoh, H. Suga*
Nature Chemical Biology, 10, 555-557 (2014)
"One-pot synthesis of azoline-containing peptides in a cell-free translation system integrated with a posttranslational cyclodehydratase."
Y. Goto*, Y. Ito, Y. Kato, S. Tsunoda, H. Suga*
Chemistry & Biology, 21, 766-774 (2014)
"Flexizymes-facilitated genetic code reprogramming leading to the discovery of drug-like peptides."
N. Terasaka, H. Suga*
Chemistry Letters, 43, 11-19 (2014)
"Protein cocrystallization molecules originating from in vitro selected macrocyclic peptides."
C.J. Hipolito, N. K. Bashiruddin, H. Suga*
Current Opinion in Structural Biology, 26, 24-31 (2014)
"Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets."
T. Shimada, K. Shimada, M. Matsui, Y. Kitai, J. Igarashi, H. Suga, A. Ishihama*
Gene to Cells, 19, 405-418 (2014)
"Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog."
A. Kodan, T. Yamaguchi, T. Nakatsu, K. Sakiyama, C.J. Hipolito, A. Fujioka, R. Hirokane, K. Ikeguchi, B. Watanabe, J. Hiratake, Y. Kimura, H. Suga, K. Ueda, H. Kato*
Proceedings of the National Academy of Sciences of the United States of America, 111, 4049-4054 (2014)
"Selection-Based Discovery of Druglike Macrocyclic Peptides."
T. Passioura, T. Katoh, Y. Goto, H. Suga*
Annual Review of Biochemistry, 83, 727-752 (2014)
"Structural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change."
K. Yamagata, Y. Goto, H. Nishimasu, J. Morimoto, R. Ishitani, N. Dohmae, N. Takeda, R. Nagai, I. Komuro, H. Suga*, O. Nureki*
Structure, 22, 345-352 (2014)
"Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation."
M. Das, O. Vargas-Rodriguez, Y. Goto, H. Suga, K. Musier-Forsyth*
Nucleic Acids Research, 42, 3943-3953 (2014)
"Aziridine formation with retention of configuration from a pentacoordinated 1,2-thiazetidine bearing two chiral centers at the 3- and 4-positions."
Y. Daicho; Y. Watanabe; N. Kano; M. Yukimoto; M. Minoura; T. Kawashima
Bull. Chem. Soc. Jpn., 87, 1005-1012 (2014)
"Synthesis, Structure, and Thermolysis of Tetracoordinated 1λ4,2-Selenazetidines Bearing Two Chiral Centers at the 3- and 4-Positions."
Y. Daicho; N. Kano; M. Yukimoto; M. Minoura; T. Kawashima
Heteroat. Chem., 25, 492-499 (2014)


"Nonstandard peptide expression under the genetic code consisting of reprogrammed dual sense codons."
Y. Goto, M. Iseki, A. Hitomi, H. Murakami, H. Suga*
ACS Chemical Biology, 8, 2630-2634 (2013)
"A macrocyclic peptide that serves as a cocrystallization ligand and inhibits the function of a MATE family transporter."
C.J. Hipolito, Y. Tanaka, T. Katoh, O. Nureki*, H. Suga*
Molecules, 18, 10514-10530 (2013)
"Structural basis for the drug extrusion mechanism by a MATE multidrug transporter."
Y. Tanaka, C.J. Hipolito, A.D. Maturana, K. Ito, T. Kuroda, T. Higuchi, T. Katoh, H.E. Kato, M. Hattori, K. Kumazaki, T, Tsukazaki, R. Ishitani*, H. Suga*, O. Nureki*
Nature, 496, 247-251 (2013)
"Flexizyme-mediated genetic reprogramming as a tool for noncanonical Peptide synthesis and drug discovery"
T. Passioura, H. Suga*
Chemistry, 19, 6530-6536 (2013)
"In Vitro Selection of Multiple Libraries Created by Genetic Code Reprogramming To Discover Macrocyclic Peptides That Antagonize VEGFR2 Activity in Living Cells"
T. Kawakami, T. Ishizawa, T. Fujino, P.C. Reid, H. Suga, H. Murakami*
ACS Chemical Biology, 8, 1205-1214 (2013)
"Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides"
K. Ito, T. Passioura, H. Suga*
Molecules, 18, 3502-3528 (2013)
"Flexizymes, Their Evolutionary History and Diverse Utilities."
T. Passioura, H. Suga*
Topics in Current Chemistry (2013)
"Reevaluation of the D-amino acid compatibility with the elongation event in translation"
T. Fujino, Y. Goto, H. Suga, H. Murakami*
Journal of the American Chemical Society, 135, 1830-1837 (2013)


"Comparative evaluation of two cell-free protein synthesis systems derived from Escherichia coli for genetic code reprogramming"
K.B. Lee, H.C. Kim, D.M. Kim, T.J. Kang*, H. Suga
Journal of Biotechnology, 164, 330-335 (2012)
"Novel acridine-based N-acyl-homoserine lactone analogs induce endoreduplication in the human oral squamous carcinoma cell line SAS."
H. Chai, M. Hazawa, Y. Hosokawa, J. Igarashi, H. Suga, I. Kashiwakura*
Biological & Pharmaceutical Bulletin, 35, 1257-1263 (2012)
"Ribosomal production and in vitro selection of natural product-like peptidomimetics: the FIT and RaPID systems."
C.J. Hipolito, H. Suga*
Current Opinion in Chemical Biology, 16, 196-203 (2012)
"Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation"
K. Iwasaki, Y. Goto, T. Katoh, H. Suga*
Organic & Biomolecular Chemistry, 10, 5783-5786 (2012)
"Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2"
J. Morimoto, Y. Hayashi, H. Suga*
Angewandte Chemie International Edition, 51, 3423-3427 (2012)
"In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors"
Y. Hayashi, J. Morimoto, H. Suga*
ACS Chemical Biology, 7, 607-613 (2012)
"Flexizymes as a tRNA acylation tool facilitating genetic code reprogramming"
Y. Goto, H. Suga*
Methods in Molecular Biology, 848, 465-478 (2012)
"Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers"
P.C. Reid, Y. Goto, T. Katoh, H. Suga*
Methods in Molecular Biology, 805, 335-348 (2012)
"Control of the Equilibrium between 2-Phosphinoazobenzenes and Inner Phosphonium Salts by Heat, Solvent, Acid, and Photoirradiation"
M. Yamamura, N. Kano*, T. Kawashima*
Bulletin of the Chemical Society of Japan 85, 110-123 (2012)
"2,2'-Diborylazobenzenes with Double N-B Coordination: Control of Fluorescent Properties by Substituents and Redox Reactions"
N. Kano*, A. Furuta, T. Kambe, J. Yoshino, Y. Shibata, T. Kawashima,* N. Mizorogi, S. Nagase
European Journal of Inorganic Chemistry 1584-1587 (2012)
"Synthesis and Properties of Water-soluble Fluorescent 2-Borylazobenzenes Bearing Ionic Functional Groups"
H. Itoi, T. Kambe, N. Kano*, T. Kawashima*
Inorganic Chimica Acta, 381, 117-123 (2012)


"Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library"
Y. Yamagishi, I. Shoji, S. Miyagawa, T. Kawakami, T. Katoh, Y. Goto, H. Suga*
Chemistry & Biology, 18, 1562-1570 (2011)
"The RNA origin of transfer RNA aminoacylation and beyond"
H. Suga*, G. Hayashi, N. Terasaka
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 366, 2959-2964. (2011)
"Ribosomal synthesis of backbone macrocyclic peptides"
T. Katoh, Y. Goto, M.S. Reza, H. Suga*
Chemical Communications, 47, 9946-9958 (2011)
"Flexizymes: their evolutionary history and the origin of catalytic function"
J. Morimoto, Y. Hayashi, K. Iwasaki, H. Suga*
Accounts of Chemical Research, 44, 1359-1368 (2011)
"Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase"
J. Chung, E. Goo, S. Yu, O. Choi, J. Lee, J. Kim, H. Kim, J. Igarashi, H. Suga, J.S. Moon, I. Hwang, S. Rhee
Proceedings of the National Academy of Sciences of the United States of America, 108, 12089-12094 (2011)
"Flexizymes for genetic code reprogramming"
Y. Goto, T. Katoh, H. Suga*
Nature Protocols, 6, 779-790 (2011)
"Formation of a Cyclic Bis(iminophosphorane) from a 2,2'-Bis(phosphino)azobenzene via N=N Bond Cleavage"
M. Yamamura, N. Kano, T. Kawashima*
Heteroatom Chemistry, 22, 301-306 (2011)
"Isolation of a Metastable Geometrical Isomer of a Hexacoordinated Dihydrophosphate: Elucidation of Its Enhanced Reactivity in Umpolung of a Hydrogen Atom of Water"
H. Miyake, N. Kano*, T. Kawashima*
Inorganic Chemistry, 50, 9083-9089 (2011)
"Translation of a histone H3 tail as a model system for studying peptidyl-tRNA drop-off"
T.J. Kang, H. Suga*
FEBS Letters, 585, 2269-2274 (2011)
"Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum"
K. Öjemalm, T. Higuchi, Y. Jiang, Ü. Langel, I. Nilsson, S.H. White, H. Suga*, G. von Heijne*
Proceedings of the National Academy of Sciences of the United States of America, 108, E359-364 (2011)
"Ribosomal Synthesis of Backbone-Macrocyclic Peptides Containing γ-Amino Acids"
Y. Ohshiro, E. Nakajima, Y. Goto, S. Fuse, T. Takahashi, T. Doi, H. Suga*
ChemBioChem, 12, 1183-1187 (2011)
"Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off"
T.J. Kang, Y. Hayashi, H. Suga*
Angewandt Chemie International Edition, 50, 2159-2161 (2011)
"Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562"
M. Hazawa, M. Kudo, T, Iwata, K. Saito, K. Takahashi, J. Igarashi, H. Suga, I. Kashiwakura*
Investigational New Drugs, 29, in press (2011)
"Custom synthesis of autoinducers and their analogues"
J. Igarashi, H. Suga*
Methods in molecular biology, 692, 265-274 (2011)


"Functional properties of synthetic N-acyl-L-homoserine lactone analogs of quorum-sensing gram-negative bacteria on the growth of human oral squamous carcinoma cells."
H. Chai, M. Hazawa, N. Shirai, J. Igarashi, K. Takahashi, Y. Hosokawa, H. Suga, I. Kashiwakura
Investigational New Drugs, 28, in press (2010)
"Ribosome evolution for two artificial amino acids in E. coli"
G. Hayashi, Y. Goto, H. Suga*
Chemistry & Biology, 17, 320-321 (2010)
"Engineering of the redox ribozyme for the determination of its architechure"
S.B. Pattnaik, K. Jin, K. Futai, H. Suga*
Chemistry Letters, 39, 786-787 (2010)


"Diverse backbone-cyclized peptides via codon reprogramming"
T. Kawakami, A. Ohta, M. Ohuchi, H. Ashigai, H. Murakami, H. Suga*
Nature Chemical Biology, 5, 888-890 (2009)
"A flexizyme that selectively charges amino acids activated by a water-friendly leaving group"
N. Niwa, Y. Yamagishi, H. Murakami, H. Suga*
Bioorganic Medicinal Chemistry Letter 19, 3892-3894 (2009)
"Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides"
Y. Goto, K. Iwasaki, K. Torikai, H. Murakami, H. Suga*
Chemical Communication 3419-3421 (2009)
"Ribosomal synthesis of cyclic peptides with a fluorogenic oxidative coupling reaction"
Y. Yamagishi, H. Ashigai, Y. Goto, H. Murakami, H. Suga*
ChemBioChem 10, 1469-1472 (2009)
"Ribosomal synthesis of peptides with C-terminal lactams, thiolactones, and alkylamides"
E. Nakajima, Y. Goto, Y. Sako, H. Murakami, H. Suga*
ChemBioChem 10, 1186-1192 (2009)
"Translation initiation with initiator tRNA charged with exotic peptides"
Y. Goto, H. Suga*
Journal of the American Chemical Society, 131, 5040-5041 (2009)
"Bases in the anticodon loop of tRNA(GGC)(Ala) prevent misreading"
H. Murakami, A. Ohta, H. Suga*
Nature Structural & Molecular Biology, 16, 353-358 (2009)


"Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids"
T. Kawakami, H. Murakami, H. Suga*
Journal of American Chemical Society 130, 16861-16863 (2008)
"Expression of histone H3 tails with combinatorial lysine modifications under the reprogrammed genetic code for the investigation on epigenetic markers"
T.-J. Kang, S. Yuzawa, H. Suga*
Chemistry & Biology 15, 1166-1174 (2008)
"Strcutural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme"
H. Xiao, H. Murakami, H. Suga, A. R. Ferre-D'Amare
Nature 454, 358-361 (2008)
"Initiating translation with D-amino acids"
Y. Goto, H. Murakami, H. Suga*
RNA 14, 1390-1398 (2008)
"Ribosomal synthesis of bicyclic peptides with two orthogonal inter-sidechain reactions"
Y. Sako, J. Morimoto, H. Murakami, H. Suga*
Journal of American Chemical Society 130, 7932-7934 (2008)
"Ribosomal synthesis of peptidase-resistant peptides closed by a non-reducible inter-sidechain bond"
Y. Sako, Y. Goto, H. Murakami, H. Suga*
ACS Chemical Biology 3, 241-249 (2008)
"Reprogramming the initiation event in translation for the synthesis of physiologically stable cyclic peptides"
Y. Goto, A. Ohta, Y. Sako, Y. Yamagishi, H. Murakami, H. Suga*
ACS Chemical Biology 3, 120-129 (2008)
"Messenger RNA-directed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides"
T. Kawakami, H. Murakami, H. Suga*
Chemistry & Biology 15, 32-42 (2008)
"Ribosomal synthesis of nonstandard peptides"
T.-J. Kang, H. Suga*
Biochemistry and Cell Biology 86, 92-99 (2008)
"Polymerization of α-hydroxy acids by ribosomes"
A. Ohta, H. Murakami, H. Suga*
ChemBioChem 9, 2773-2778 (2008)
"Synthesis of biopolymers using genetic code reprogramming"
A. Ohta, Y. Yamagishi, H. Suga*
Current Opinion in Chemical Biology 12, 159-167 (2008)


"Electronic Excitation Energy Transfer in DNA. Nature of Triplet Excitations Capturing Centers"
V.M. Yashchuk, V. Y. Kudrya, M. Y. Losytskyy, I. Y. Dubey, H. Suga*
Molecular Crystals and Liquid Crystals 467, 311-323. (2007)
"Synthetic and Biological Functional Compounds with Direct Excitons Conductivity for Nanoelectronic Devices"
Valeriy M. Yashchuk; Vladislav Yu. Kudrya; Irina V. Savchenko; Grygoriy P. Golovach; Igor Ya. Dubey; Rostyslav D. Fedorovich; Hiroaki Suga; Juozas V. Grazulevicius
Molecular Crystals and Liquid Crystals, 1563-5287, Volume 468, 2007, Pages 275/[627] – 288/[640]
"Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump"
Y.Y. Chan, H.S. Bian, T.M. Tan, M.E. Mattmann, G.D. Geske, J. Igarashi, T. Hatano, H. Suga, H.E. Blackwell, K.L. Chua
Journal of Bacteriology 189, 4320-4324 (2007)
"Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae"
J. Kim, Y. Kang, O. Choi, Y. Jeong, J.E. Jeong, J.Y. Lim, M. Kim, J.S. Moon, H. Suga, I. Hwang
Molecular Microbiology 64, 165-179 (2007)
"N-(3-hydroxyhexanoyl)-l-homoserine lactone is the biologically relevant quormone that regulates the phz operon of Pseudomonas chlororaphis strain 30-84"
S. R. Khan, J. Herman, J. Krank, N. J. Serkova, M. E. Churchill, H. Suga, S. K. Farrand
Applied Environmental Microbiology 73(22), 7443-7455.(2007)
"Synthesis of polyester by means of genetic code reprogramming"
A. Ohta, H. Murakami, E. Higashimura, H. Suga*
Chemistry & Biology 14, 1315-1322 (2007)
"The flexizyme system: A highly flexible tRNA aminoacyation tool for the translation apparatus"
M. Ohuchi, H. Murakami, H. Suga*
Current Opinion in Chemical Biology 11, 135-144 (2007)
"The nature of the electronic excitations capturing centres in the DNA"
V.M. Yashchuk, V. Y. Kudrya, M. Y. Losytskyy, H. Suga, T. Ohul'chanskyy (2006)
Journal of Molecular Liquids 127, 79–83.
"Leucyl/Phenylalanyl-tRNA-protein transferase-mediated chemoenzymatic coupling of N-terminal Arg/Lys units in post-translationally processed proteins with non-natural amino acids"
Taki M, Kuno A, Matoba S, Kobayashi Y, Futami J, Murakami H, Suga H, Taira K, Hasegawa T, Sisido
M. ChemBioChem 7, 1676-1679 (2006).
"A highly flexible tRNA acylation method for nonnatural polypeptide synthesis"
H. Murakami, A. Ohta, H. Ashigai, H. Suga* (2006)
Nature Methods 3, 357-359.
"Stereoisomers of P. aeruginosa autoinducer Analog to probe the regulator binding site"
G. Jog, J. Igarashi, H. Suga* (2006)
Chemistry & Biology 13, 123-128.
"Activation of the phz operon of Pseudomonas fluorescens 2-79 requires the LuxR homolog PhzR, N-(3-OH-Hexanoyl)-L-homoserine lactone produced by the LuxI homolog PhzI, and a cis-acting phz box"
S.R. Khan, D.V. Mavrodi, G.J. Jog, H. Suga, L.S. Thomashow, S.K. Farrand (2005)
Journal of Bacteriology 187, 6517-6527.
"Programmable ribozymes for mischarging tRNA with nonnatural amino acids and their applications to translation"
D. Kourouklis, H. Murakami, H. Suga* (2005)
Methods, 36(3), 239-244.
"Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae"
J. Kim, J.-G. Kim, Y. Kang, J. Y. Jang, G. J. Jog, J. Y. Lim, S. Kim, H. Suga, T. Nagamatsu and I. Hwang (2004)
Molecular Microbiology 54, 921-934.
"Designer ribozymes: Programming tRNA specificity into Flexizyme"
K. Ramaswamy, H. Saito, H. Murakami, K. Shiba, H. Suga* (2004)
Journal of American Chemical Society 126, 11454-11455.
"Reduction of an aldehyde by a NADH/Zn2+-dependent redox active ribozyme"
S. Tsukiji, S. Pattnaik, H. Suga* (2004)
Journal of American Chemical Society 126, 5044-5045.
"Ribozymes that use redox cofactors"
S. Tsukiji, K. Ramaswamy, H. Suga* (2004)
Pure & Applied Chemistry 76, 1525-1536.
"Using a solid-phase ribozyme aminoacylation system to reprogram the genetic code"
H. Murakami, D. Kourouklis, H. Suga* (2003)
Chemistry & Biology 10, 1077-1084.
"An alcohol dehydrogenase ribozyme"
S. Tsukiji, S. B. Pattnaik, H. Suga* (2003) "
Nature Structural Biology 10, 713-717.
"A versatile tRNA aminoacylation catalyst based on RNA"
A H. Murakami, H. Saito, H. Suga* (2003)
Chemistry & Biology 10, 655-662
"Library screening for synthetic agonists and antagonists of Pseudomonas aeruginosa autoinudcer"
K. Smith, Y. Bu, H. Suga* (2003)
Chemistry & Biology 10, 563-571.
E "Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs"
K. Smith, Y. Bu, H. Suga* (2003)
Chemistry & Biology 10, 81-89.
"Molecular mechanisms of bacterial quorum sensing as a new drug target"
H. Suga* and K. M. Smith (2003)
Current Opinion in Chemical Biology 7, 589-591.
"Mechanistic studies on acyl transferase ribozymes and beyond"
D. Hodgson, H. Suga* (2003)
Biopolymers 10, 1077-1084.
"Outersphere and innersphere coordinated metal ions in an aminoacyl-tRNA synthetase ribozyme"
H. Saito, H. Suga* (2002)
Nucleic Acid Research 30, 5151-5159.
A "A tRNA aminoacylation system for non-natural amino acids based on a programmable ribozyme"
Y. Bessho, D. Hodgson, H. Suga* (2002)
Nature Biotechnology 20, 723-728.
"Aminoacyl-tRNA synthesis by a resin-immobilized ribozyme"
H. Murakami, N. J. Bonzagni, H. Suga* (2002)
Journal of American Chemical Society 124, 6834-6835.
"Minihelix-loop RNAs: Minimal structure for the emergence of a primitive aminoacylation system"
K. Ramaswarmy, K. Wei, H. Suga* (2002)
Nucleic Acid Research 30, 2162-2171.
"Recognition of Phosphate and Sugar Groups in tRNACys for Aminoacylation: Evolution from E. coli to Human"
X. Ming, K. Smith, H. Suga, and Y.-M. Hou (2002)
Journal of Molecular Biology 318, 1207-20.
"Concurrent molecular recognition of the amino acid and tRNA by a ribozyme"
H. Saito, K. Watanabe, H. Suga* (2001)
RNA 7,1867-1878.
"A single metal ion plays structural and chemical roles in an acyl-transferase ribozyme"
A. Flynn-Charlebois, N. Lee, H. Suga* (2001)
Biochemistry 40, 13623-13632.
"Essential roles of inner-sphere metal ions for the formation of the glutamine binding site in a bifunctional ribozyme"
N. Lee, H. Suga* (2001)
Biochemistry 40, 13633-13643.
"A ribozyme aminoacylates exclusively on the 3'-hydroxyl group of the 3'-terminus of tRNA"
H. Saito, H. Suga* (2001)
Journal of American Chemical Society 123, 7178-7179.
"Diverse roles of metal ions in acyl-transferase ribozymes"
A. Vaidya, H. Suga* (2001)
Biochemistry 40, 7200-7210.
"A mini-helix-loop RNA acts as a trans-acting aminoacylation catalyst"
N. Lee, H. Suga* (2001)
RNA 7, 1043-1051.
"An In vitro evolved precursor tRNA with aminoacylation activity"
H. Saito, D. Kourouklis, H. Suga* (2001)
EMBO Journal 20, 1797-1806.
"Ribozyme-catalyzed tRNA aminoacylation"
N. Lee, Y. Bessho, K. Wei, J.W. Szostak, H. Suga* (2000)
Nature Structural Biology 7, 28-34.
"Unusual Metal Ion Catalysis in an Acyl-Transferase Ribozyme"
H. Suga, J.A. Cowan, J.W. Szostak (1998)
Biochemistry 37, 10118-10125.
"The Secondary Structure and Essential Catalytic Features of an Acyl Transferase Ribozyme"
H. Suga, P.A. Lohse, J.W. Szostak (1998)
Journal of American Chemical Society 120, 1151-1156.
"Electrogeneration of Triphenyltin Radical, Anion, and Cation. Electrochemical Initiation of Tin Hydride-Promoted Radical Chain Reactions"
H. Tanaka, H. Ogawa, H. Suga, S. Torii, A. Jutand, S. Aziz, A.G. Suarez, C. Amatore
Journal of Organic
"Catalytic antibodies generated via homologous and heterologous immunization"
T. Tsumuraya, H. Suga, S. Meguro, A. Tsunakawa, S. Masamune (1995)
Journal of American Chemical Society 117, 11390-11396.
"Glycosidase antibodies induced to a half-chair transition-state analog"
H. Suga, N. Tanimoto, A.J. Sinskey, S. Masamune (1994)
Journal of American Chemical Society 116, 11197-11198.
"Catalytic antibodies generated via heterologous immunization"
H. Suga, O. Ersoy, S.F. Williams, T. Tsumuraya, M.N. Margolies, A.J. Sinskey, S. Masamune (1994)
Journal of American Chemical Society 116, 6025-6026.
"Catalytic antibodies generated via heterologous immunization"
H. Suga, O. Ersoy, T. Tsumuraya, J. Lee, A.J. Sinskey, S. Masamune (1994)
Journal of American Chemical Society 116, 487-494.
"Electrooxidative initiation of tin hydride-promoted radical chain reactions"
H. Tanaka, H. Suga, H. Ogawa, A.K.M. Abdul Hai, S. Torii, A. Jutand, C. Amatore (1992)
Tetrahedron Letters 33, 6495-6498.
"Vicinal bromofluoroalkanes: their regioselective formation and their conversion to fluoroolefins"
H. Suga, T. Hamatani, Y. Guggisberg, M. Schlosser (1990)
Tetrahedron 46, 4255-4260.
"α-Fluoro- and α,α-difluoroalkanals by substitution of vicinal bromofluoroalkanes and subsequent pummerer rearrangement"
H. Suga, M. Schlosser (1990)
Tetrahedron 46, 4261-4264.
"Regioselective formation of fluorohydrins and their stereoselective conversion to fluoroolefins"
H. Suga, T. Hamatani, M. Schlosser (1990)
Tetrahedron 46, 4247-4254.