Naohiro Terasaka, Ph.D.

Project Assistant Professor



B.Sc., School of Engineering, The University of Tokyo
Thesis advisor Prof. Tsutomu Suzuki
M.Sc., Graduate School of Engineering, The University of Tokyo
Thesis advisor Prof. Hiroaki Suga
Ph.D., Graduate School of Science, The University of Tokyo
Thesis advisor: Prof. Hiroaki Suga

Professional career

Research Fellow of the Japan Society for the Promotion of Science
Postdoctoral research associate, ETH Zurich
(HFSP Long-term fellowship)
Advisor, Prof. Donald Hilvert
Project assistant professor, Graduate School of Science, The University of Tokyo


"Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein."
S. Tetter; N. Terasaka; A. Steinauer; R.J. Bingham; S. Clark; A.P. Scott; N. Patel; M. Leibundgut; E. Wroblewski; N. Ban; P.G. Stockley; R. Twarock; D. Hilvert
Science., 372, 1220 (2021)
"Macrocyclic peptide–mediated blockade of the CD47-SIRPα interaction as a potential cancer immunotherapy."
D. Hazama; Y. Yin; Y. Murata; M. Matsuda; T. Okamoto; D. Tanaka; N. Terasaka; J. Zhao; M. Sakamoto; Y. Kakuchi; Y. Saito; T. Kotani; Y. Nishimura; A. Nakagawa; H. Suga; T. Matozaki
Cell Chem. Biol., 27, 1181 (2020)
"An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch."
S. Ishida; N. Terasaka; T. Katoh; H. Suga
Nat Chem Biol, 16, 702 (2020)
"Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies."
H.L.P. Tytgat; C.L. Lin; M.D. Levasseur; M.B. Tomek; C. Rutschmann; J. Mock; N. Liebscher; N. Terasaka; Y. Azuma; M. Wetter; M.F. Bachmann; D. Hilvert; M. Aebi; T.G. Keys
Nat Commun, 10, 5403 (2019)
"Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1."
S.T.P. Tran; C.J. Hipolito; H. Suzuki; R. Xie; H.D.K. Tuyen; P. ten Dijke; N. Terasaka; Y. Goto; H. Suga; M. Kato
Biochem Bioph Res Co, 516, 445-450 (2019)
"Laboratory evolution of virus-like nucleocapsids from nonviral protein cages."
N. Terasaka; Y. Azuma; D. Hilvert
Proc. Natl. Acad. Sci. U. S. A., (2018)
"Modular protein cages for size-selective RNA packaging in vivo."
Y. Azuma; T. Edwardson; N. Terasaka; D. Hilvert
J. Am. Chem. Soc., 140, 566-569 (2018)
"A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX."
N. Terasaka; K. Futai; T. Katoh; H. Suga
RNA, 22, 1918-1928 (2016)
"tRid, an enabling method to isolate previously inaccessible small RNA fractions."
K. Futai; N. Terasaka; T. Katoh; H. Suga
Methods, 106, 105-111 (2016)
"Recent Developments of Engineered Translational Machineries for the Incorporation of Non-Canonical Amino Acids into Polypeptides."
N. Terasaka; Y. Iwane; A.S. Geiermann; Y. Goto; H. Suga
Int J Mol Sci, 16, 6513-6531 (2015)
"An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center."
N. Terasaka; G. Hayashi; T. Katoh; H. Suga
Nat. Chem. Biol., 10, 555-557 (2014)
"Flexizymes-facilitated genetic code reprogramming leading to the discovery of drug-like peptides."
N. Terasaka; H. Suga
Chem. Lett., 43, 11-19 (2014)
"The RNA origin of transfer RNA aminoacylation and beyond."
H. Suga; G. Hayashi; N. Terasaka
Phil. Trans. R. Soc. B, 366, 2959-2964 (2011)
"Crystallization and preliminary X-ray diffraction analysis of an archaeal tRNA-modification enzyme, TiaS, complexed with tRNA(Ile2) and ATP."
T. Osawa; H. Inanaga; S. Kimura; N. Terasaka; T. Suzuki; T. Numata
Acta crystallographica. Section F, Structural biology and crystallization communications, 67, 1414-1416 (2011)
"Structural basis of tRNA agmatinylation essential for AUA codon decoding."
T. Osawa; S. Kimura; N. Terasaka; H. Inanaga; T. Suzuki; T. Numata
Nat. Struct. Mol. Biol., 18, 1275-1280 (2011)
"Biogenesis of 2-agmatinylcytidine catalyzed by the dual protein and RNA kinase TiaS."
N. Terasaka; S. Kimura; T. Osawa; T. Numata; T. Suzuki
Nat. Struct. Mol. Biol., 18, 1268-1274 (2011)

Contact Info

  • Room #2208, West wing, Chemistry Bildg.
    Department of Chemistry, Graduate School of Science, The University of Tokyo
  • E-mail… n_terasaka"at"chem.s.u-tokyo.ac.jp (change "at" to @)
  • TEL…+81-3-5841-4638
  • FAX…+81-3-5841-8372