Sven Ullrich
Feodor Lynen Postdoctoral Fellow
- City/country of origin
- Ludwigshafen, Germany
- Hobbies
- Sports, podcasts and cooking
- Where for a big vacation
- Adriatic Coast
- What are your strong points?
- Writing and presenting
- What was surprising about the Suga lab
- Separate buildings for students and postdocs
- Original motivation towards science?
- Nature, Sci-Fi and my parents
- Science is
- creating knowledge
Education & professional career
- 2020-2024
- Australian National University, Chemistry, Doctor of Philosophy
- 2015-2019
- Heidelberg University, Pharmacy, State Examinations
Publications
- "Exploiting hydrophobic amino acid scanning to develop cyclic peptide inhibitors of the SARS‐CoV‐2 main protease with antiviral activity."
- K. Harrison; P.W. Carlos; S. Ullrich; A. Aggarwal; J. Johansen‐Leete; V.M. Sasi; I. Barter; J.W.C. Maxwell; M.J. Bedding; M. Larance; S. Turville; A. Norman; C.J. Jackson; C. Nitsche; R.J. Payne
- Chem. Eur. J., 30, e202401606 (2024)
- "Synthesis and stability studies of constrained peptide–antimony bicycles."
- S. Ullrich; P. Ghosh; M. Shang; S. Siryer; S. Kumaresan; B. Panda; L.J. Davies; U. Somathilake; A.P. Patel; C. Nitsche
- Austr. J. Chem., 77, CH24094 (2024)
- "A RaPID response to SARS‐CoV‐2."
- S. Ullrich; C. Nitsche
- Isr. J. Chem., e202300170 (2024)
- "Bicyclic peptides: paving the road for therapeutics of the future."
- S. Ullrich; C. Nitsche
- Pept. Sci., 116, e24326 (2024)
- "Phage-encoded bismuth bicycles enable instant access to targeted bioactive peptides."
- S. Ullrich; U. Somathilake; M. Shang; C. Nitsche
- Commun. Chem., 7, 143 (2024)
- "Probing ligand binding sites on large proteins by nuclear magnetic resonance spectroscopy of genetically encoded non-canonical amino acids."
- K.B. Ekanayake; M.C. Mahawaththa; H. Qianzhu; E.H. Abdelkader; J. George; S. Ullrich; R.B. Murphy; S.E. Fry; J. Johansen-Leete; R.J. Payne; C. Nitsche; T. Huber; G. Otting
- J. Med. Chem., 66, 5289-5304 (2023)
- "Antiviral cyclic peptides targeting the main protease of SARS-CoV-2."
- J. Johansen-Leete; S. Ullrich; S.E. Fry; R. Frkic; M.J. Bedding; A. Aggarwal; A.S. Ashhurst; K.B. Ekanayake; M.C. Mahawaththa; V.M. Sasi; S. Luedtke; D.J. Ford; A.J. O'Donoghue; T. Passioura; M. Larance; G. Otting; S. Turville; C.J. Jackson; C. Nitsche; R.J. Payne
- Chem. Sci., 13, 3826-3836 (2022)
- "Site-selective generation of lanthanoid binding sites on proteins using 4-fluoro-2,6-dicyanopyridine."
- S. Mekkattu Tharayil; M.C. Mahawaththa; A. Feintuch; A. Maleckis; S. Ullrich; R. Morewood; M.J. Maxwell; T. Huber; C. Nitsche; D. Goldfarb; G. Otting
- Magn. Reson., 3, 169-182 (2022)
- "Predicting antiviral resistance mutations in SARS-CoV-2 main protease with computational and experimental screening."
- V.M. Sasi; S. Ullrich; J. Ton; S.E. Fry; J. Johansen-Leete; R.J. Payne; C. Nitsche; C.J. Jackson
- Biochemistry, 61, 2495-2505 (2022)
- "Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir."
- S. Ullrich; K.B. Ekanayake; G. Otting; C. Nitsche
- Bioorg. Med. Chem. Lett., 62, 128629 (2022)
- "Biocompatible and selective generation of bicyclic peptides."
- S. Ullrich; J. George; A.E. Coram; R. Morewood; C. Nitsche
- Angew. Chem. Int. Ed., 61, e202208400 (2022)
- "SARS‐CoV‐2 papain‐like protease: structure, function and inhibition."
- S. Ullrich; C. Nitsche
- ChemBioChem, 23, e202200327 (2022)
- "Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors."
- S. Ullrich; V.M. Sasi; M.C. Mahawaththa; K.B. Ekanayake; R. Morewood; J. George; L. Shuttleworth; X. Zhang; C. Whitefield; G. Otting; C. Jackson; C. Nitsche
- Bioorg. Med. Chem. Lett., 50, 128333 (2021)
- "The SARS-CoV-2 main protease as drug target."
- S. Ullrich; C. Nitsche
- Bioorg. Med. Chem. Lett., 30, 127377 (2020)
Contact info
-
- E-mail… sullrich"at"g.ecc.u-tokyo.ac.jp (change "at" to @)
