Yichao Huang黃 軼超

Postdoctoral Fellow

City/country of origin
Shanghai, China
Jogging, reading, playing harmonica occassionally ...
Places You Like
With blue sky and no haze.
Where for a big vacation
Other places in Japan, Hokkaido, Okinawa ...
What are your strong points?
Naive smile, maybe.
Music: what is some intense music for intense lab work?
あなただけみつめてる、YAH YAH YAH
What are people in the lab doing?
Switching roles between synthetic chemist and synthetic biologist.
What was surprising about the suga lab
A lot of brainstorming.
Original motivation towards science?
Seeing a chemical structure on the label of a flu drug bottle.
A few words for future lab mates
Studying some Hiragana and Katakana letters can be helpful.
Science is ……
The more you discover, the more is waiting to be explored.

Education & professional career

B.S., Chemical Biology, Tsinghua University
PhD, Bioorganic Chemistry, Tsinghua University
Postdoctoral fellow, Bioorganic Chemistry, The University of Tokyo


"Chemical Synthesis of K48-Linked Diubiquitin by Incorporation of a Lysine-Linked Auxiliary Handle."
R.-L. Xie; L. Xu; J.-B. Li; G.-C. Chu; T. Wang; Y.-C. Huang; Y.-M. Li
European Journal of Organic Chemistry, 2665-2670 (2016)
"Hmb(off/on) as a switchable thiol protecting group for native chemical ligation."
Y.-K. Qi; S. Tang; Y.-C. Huang; M. Pan; J.-S. Zheng; L. Liu
Organic & Biomolecular Chemistry, 14, 4194-4198 (2016)
"Quasi-Racemic X-ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis."
M. Pan; S. Gao; Y. Zheng; X. Tan; H. Lan; X. Tan; D. Sun; L. Lu; T. Wang; Q. Zheng; Y. Huang; J. Wang; L. Liu
Journal of the American Chemical Society, 138, 7429-7435 (2016)
"Ubiquitin 7-amino-4-carbamoylmethylcoumarin as an improved fluorogenic substrate for deubiquitinating enzymes."
Y.-T. Li; Y.-C. Huang; Y. Xu; M. Pan; Y.-M. Li
Tetrahedron, 72, 4085-4090 (2016)
"KAHA Ligation at Serine."
Y.-M. Li; Y.-C. Huang; L. Liu
Chembiochem, 17, 28-30 (2016)
"Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation."
H. Lan; K. Wu; Y. Zheng; M. Pan; Y.-C. Huang; S. Gao; Q.-Y. Zheng; J.-S. Zheng; Y.-M. Li; B. Xiao; L. Liu
Journal of peptide science : an official publication of the European Peptide Society, 22, 320-326 (2016)
"Chemical synthesis of proteins using hydrazide intermediates."
Y.-C. Huang; G.-M. Fang; L. Liu
National Science Review, 3, 107-116 (2016)
"Synthesis of l- and d-Ubiquitin by One-Pot Ligation and Metal-Free Desulfurization."
Y.-C. Huang; C.-C. Chen; S. Gao; Y.-H. Wang; H. Xiao; F. Wang; C.-L. Tian; Y.-M. Li
Chemistry (Weinheim an der Bergstrasse, Germany), 22, 7623-7628 (2016)
"Protein modification: Standing out from the crowd."
Y. Huang; L. Liu
Nature chemistry, 8, 101-102 (2016)
"Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones."
Y.-C. Huang; C.-J. Guan; X.-L. Tan; C.-C. Chen; Q.-X. Guo; Y.-M. Li
Organic & Biomolecular Chemistry, 13, 1500-1506 (2015)
"Chemical synthesis of crystalline proteins."
Y. Huang; L. Liu
Science China-Chemistry, 58, 1779-1781 (2015)
"Irreversible Site-Specific Hydrazinolysis of Proteins by Use of Sortase."
Y.-M. Li; Y.-T. Li; M. Pan; X.-Q. Kong; Y.-C. Huang; Z.-Y. Hong; L. Liu
Angewandte Chemie-International Edition, 53, 2198-2202 (2014)
"Facile synthesis of C-terminal peptide hydrazide and thioester of NY-ESO-1 (A39-A68) from an Fmoc-hydrazine 2-chlorotrityl chloride resin."
Y.-C. Huang; C.-C. Chen; S.-J. Li; S. Gao; J. Shi; Y.-M. Li
Tetrahedron, 70, 2951-2955 (2014)
"Facile solid-phase synthesis of PNA-peptide conjugates using pNZ-protected PNA monomers."
Y.-C. Huang; C. Cao; X.-L. Tan; X. Li; L. Liu
Organic Chemistry Frontiers, 1, 1050-1054 (2014)
"Thiol-assisted one-pot synthesis of peptide/protein C-terminal thioacids from peptide/protein hydrazides at neutral conditions."
C. Chen; Y. Huang; L. Xu; Y. Zheng; H. Xu; Q. Guo; C. Tian; Y. Li; J. Shi
Organic & Biomolecular Chemistry, 12, 9413-9418 (2014)
"Development of New Thioester Equivalents for Protein Chemical Synthesis."
J.-S. Zheng; S. Tang; Y.-C. Huang; L. Liu
Accounts of Chemical Research, 46, 2475-2484 (2013)
"Thiol-yne radical reaction mediated site-specific protein labeling via genetic incorporation of an alkynyl-L-lysine analogue."
Y. Li; M. Pan; Y. Li; Y. Huang; Q. Guo
Organic & Biomolecular Chemistry, 11, 2624-2629 (2013)
"Synthesis of Autophagosomal Marker Protein LC3-II under Detergent-Free Conditions."
Y.-C. Huang; Y.-M. Li; Y. Chen; M. Pan; Y.-T. Li; L. Yu; Q.-X. Guo; L. Liu
Angewandte Chemie-International Edition, 52, 4858-4862 (2013)
"Ligation of Expressed Protein alpha-Hydrazides via Genetic Incorporation of an alpha-Hydroxy Acid."
Y.-M. Li; M.-Y. Yang; Y.-C. Huang; Y.-T. Li; P.R. Chen; L. Liu
Acs Chemical Biology, 7, 1015-1022 (2012)
"Genetically encoded alkenyl-pyrrolysine analogues for thiol-ene reaction mediated site-specific protein labeling."
Y. Li; M. Yang; Y. Huang; X. Song; L. Liu; P.R. Chen
Chemical Science, 3, 2766-2770 (2012)
"Chemical Synthesis of Integral Membrane Proteins: Methods and Applications."
F. Shen; Y.-C. Huang; S. Tang; Y.-X. Chen; L. Liu
Israel Journal of Chemistry, 51, 940-952 (2011)
"Protein Chemical Synthesis by Ligation of Peptide Hydrazides."
G.-M. Fang; Y.-M. Li; F. Shen; Y.-C. Huang; J.-B. Li; Y. Lin; H.-K. Cui; L. Liu
Angewandte Chemie-International Edition, 50, 7645-7649 (2011)

Contact info

    • E-mail… hycjimmy"at"chem.s.u-tokyo.ac.jp (change "at" to @)