{"id":1840,"date":"2025-05-29T12:00:00","date_gmt":"2025-05-29T03:00:00","guid":{"rendered":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/?p=1840"},"modified":"2025-06-16T14:00:00","modified_gmt":"2025-06-16T05:00:00","slug":"zasshikai-seminar-1997th-associate-professor-fabrice-michel-flow-chemistry-concepts-and-techniques-applied-to-solid-phase-oligonucleotide-synthesis","status":"publish","type":"post","link":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/jp\/jp-finseminar\/events1840","title":{"rendered":"Zasshikai seminar 1997th, Associate professor Fabrice MICHEL, \u201cFlow Chemistry Concepts and Techniques Applied to Solid Phase Oligonucleotide Synthesis\u201d"},"content":{"rendered":"\n<p><strong>Abstract<\/strong>:Maintaining genome integrity is necessary for the survival of organisms.<br>Genomes face continuous threats not only from external mutagenic factors<br>but also intrinsically from mobile genetic elements known as<br>transposable elements (TEs). Although potentially deleterious, TEs are a<br>major component of plant and animal genomes and have contributed to<br>genome evolution through their mobility.<br>The RdDM (RNA-directed DNA methylation) pathway inhibits TE expression<br>in plants. This inactivation also extends to adjacent genes, leading to<br>transcriptional repression that is propagated over several generations<br>via so-called epigenetic mechanisms. RNA polymerase IV (Pol IV)<br>initiates the RdDM pathway by transcribing TEs in the nucleus. The<br>resulting non-coding RNAs are recognised by the RNA-dependent RNA<br>polymerase RDR2, which generates double-stranded RNAs (dsRNAs). These<br>are then cut into small interfering RNAs (siRNAs) of 24 nucleotides that<br>guide DNA methylation towards TEs throughout the genome.<br>This talk will focus on the functional assembly of the RNA Polymerase IV<br>(Pol IV) complex in plants, emphasizing the roles of associated proteins<br>in small RNA biogenesis and transposon silencing. Recent insights into<br>the molecular interactions that guide Pol IV recruitment and activity<br>will also be presented.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract:Maintaining genome integrity is necessary for the survival of organisms.Genomes face continuous threa [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,11],"tags":[],"class_list":["post-1840","post","type-post","status-publish","format-standard","hentry","category-en-finseminar","category-jp-finseminar"],"publishpress_future_action":{"enabled":false,"date":"2026-05-08 15:01:00","action":"category","newStatus":"draft","terms":[11,12],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/posts\/1840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/comments?post=1840"}],"version-history":[{"count":1,"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/posts\/1840\/revisions"}],"predecessor-version":[{"id":1841,"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/posts\/1840\/revisions\/1841"}],"wp:attachment":[{"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/media?parent=1840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/categories?post=1840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.chem.s.u-tokyo.ac.jp\/events\/wp-json\/wp\/v2\/tags?post=1840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}