goda@chem.s.u-tokyo.ac.jp +81-3-5841-4329

Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for vibrational spectroscopy as it provides several orders of magnitude higher sensitivity than inherently weak spontaneous Raman scattering by exciting localized surface plasmon resonance (LSPR) on metal substrates. However, SERS is not very reliable for biomedical use since it sacrifices measurement reproducibility, surface enhancement uniformity, compatibility to biological molecules, and durability due to its strong dependence on LSPR-derived "hot spots", large photothermal heat generation, and easy oxidization.

We aim to design, fabricate, and use a new class of SERS substrates for a new era of SERS. Specifically, we have recently developed a metal-free (i.e., LSPR-free), topologically tailored nanostructure composed of porous carbon nanowires in an array as a SERS substrate to overcome all these problems. It offers not only high signal enhancement due to its strong broadband charge-transfer resonance, but also extraordinarily high measurement reproducibility due to the absence of hot spots, high durability due to no oxidization, and high compatibility to biological molecules due to its fluorescence quenching capability. Furthermore, we have demonstrated wearable SERS based on a gold nanomesh substrate that provides a high density of hot spots and hence overcomes the low measurement reproducibility problem. Currently, we work on the development of a new family of carbon-based SERS substrates and the exploitation of new biomedical applications based on the substrates.


References


New Directions in SERS

  • Field leader: Yasutaka Kitahama
  • Funding: JSPS Core-to-Core Program, MEXT Q-Leap, White Rock Foundation
  • Collaboration: Serendipity Lab