相川 春夫Haruo Aikawa

助教

出身地
茨城県つくば市
好きなこと・もの
旅行、ドライブ、温泉、滝巡り、食べること
もし大型連休がとれたら?
世界遺産巡り。本気で痩せる!
これだけは誰にも負けないぞ!
なんでも美味しく食べられる。チャレンジ精神
研究がクライマックス時の脳内テーマソング
直近で耳にしたノリの良い曲。今はIt’s My Life
菅研、見渡すと何をしている人が多い?
奮闘
菅研究室に入って良い意味でびっくりしたこと
自由さ
研究へのモチベーションの源は?
妄想の実現とその妄想の斜め上をいく発見
未来の後輩にメッセージ
なんでもやってみましょう!
科学とは○○である
新常識を生み出す事

学歴・職歴

2004年3月:
東北大学理学部化学科 卒業
2009年3月:
東北大学大学院理学研究科化学専攻 博士課程修了(山本嘉則・浅尾直樹研究室)
2009年4月:
東北大学国際高等研究教育機構 助教(山口雅彦研究室)
2011年6月:
東京医科歯科大学生体材料工学研究所 特任助教(玉村啓和研究室)
2013年8月:
大阪大学産業科学研究所 特任助教(中谷和彦研究室)
2018年3月:
米国スクリプス研究所(フロリダ) 博士研究員(Matthew Disney研究室)
2021年5月:
東京大学理学系研究科 博士研究員
2022年10月:
東京大学理学系研究科 助教

発表論文

"Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion."
Q.M.R. Gibaut; Y. Akahori; J.A. Bush; A. Taghavi; T. Tanaka; H. Aikawa; L.S. Ryan; B.M. Paegel; M.D. Disney
J Am Chem Soc, (2022)
"A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G(4)C(2))(exp) in c9ALS/FTD via the nuclear RNA exosome."
J.A. Bush; S.M. Meyer; R. Fuerst; Y. Tong; Y. Li; R.I. Benhamou; H. Aikawa; P.R.A. Zanon; Q.M.R. Gibaut; A.J. Angelbello; T.F. Gendron; Y.J. Zhang; L. Petrucelli; T. Heick Jensen; J.L. Childs-Disney; M.D. Disney
Proc Natl Acad Sci U S A, 119, e2210532119 (2022)
"A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype."
H.S. Haniff; X. Liu; Y. Tong; S.M. Meyer; L. Knerr; M. Lemurell; D. Abegg; H. Aikawa; A. Adibekian; M.D. Disney
Cell Chem Biol, (2021)
"Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models."
J.A. Bush; H. Aikawa; R. Fuerst; Y. Li; A. Ursu; S.M. Meyer; R.I. Benhamou; J.L. Chen; T. Khan; S. Wagner-Griffin; M.J. Van Meter; Y. Tong; H. Olafson; K.K. McKee; J.L. Childs-Disney; T.F. Gendron; Y. Zhang; A.N. Coyne; E.T. Wang; I. Yildirim; K.W. Wang; L. Petrucelli; J.D. Rothstein; M.D. Disney
Sci Transl Med, 13, eabd5991 (2021)
"Small molecule recognition of disease-relevant RNA structures."
S.M. Meyer; C.C. Williams; Y. Akahori; T. Tanaka; H. Aikawa; Y. Tong; J.L. Childs-Disney; M.D. Disney
Chem Soc Rev, 49, 7167-7199 (2020)
"Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands."
X. Liu; H.S. Haniff; J.L. Childs-Disney; A. Shuster; H. Aikawa; A. Adibekian; M.D. Disney
J Am Chem Soc, 142, 6970-6982 (2020)
"Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer."
M.G. Costales; H. Aikawa; Y. Li; J.L. Childs-Disney; D. Abegg; D.G. Hoch; S.P. Velagapudi; Y. Nakai; T. Khan; K.W. Wang; I. Yildirim; A. Adibekian; E.T. Wang; M.D. Disney
P Natl Acad Sci USA, 117, 2406-2411 (2020)
"Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing."
J.L. Chen; P. Zhang; M. Abe; H. Aikawa; L. Zhang; A.J. Frank; T. Zembryski; C. Hubbs; H. Park; J. Withka; C. Steppan; L. Rogers; S. Cabral; M. Pettersson; T.T. Wager; M.A. Fountain; G. Rumbaugh; J.L. Childs-Disney; M.D. Disney
J Am Chem Soc, 142, 8706-8727 (2020)
"Expanding chemical space of DNA-binding molecules with three base-binding units."
Y. Yagi; H. Aikawa; T. Yamada; K. Nakatani
Bioorg Med Chem Lett, 28, 2894-2898 (2018)
"A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH."
H. Aikawa; A. Yano; K. Nakatani
Org Biomol Chem, 15, 1313-1316 (2017)
"Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization."
T. Nakamura; J.R. Campbell; A.R. Moore; S. Otsu; H. Aikawa; H. Tamamura; H. Mitsuya
J Virol Methods, 236, 196-206 (2016)
"Exploration of labeling by near infrared dyes of the polyproline linker for bivalent-type CXCR4 ligands."
W. Nomura; H. Aikawa; S. Taketomi; M. Tanabe; T. Mizuguchi; H. Tamamura
Bioorg Med Chem, 23, 6967-6973 (2015)
"Exploratory Study on the RNA-Binding Structural Motifs by Library Screening Targeting pre-miRNA-29 a."
T. Fukuzumi; A. Murata; H. Aikawa; Y. Harada; K. Nakatani
Chemistry, 21, 16859-16867 (2015)
"Synthesis of 8-Substituted Adenine and Adenosine Libraries and the Binding to pre-miR-29a."
T. Fukuzumi; H. Aikawa; Y. Harada; A. Sugai; A. Murata; K. Nakatani
B Chem Soc Jpn, 87, 1013-1015 (2014)
"Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products."
W. Nomura; H. Aikawa; N. Ohashi; E. Urano; M. Metifiot; M. Fujino; K. Maddali; T. Ozaki; A. Nozue; T. Narumi; C. Hashimoto; T. Tanaka; Y. Pommier; N. Yamamoto; J.A. Komano; T. Murakami; H. Tamamura
ACS Chem Biol, 8, 2235-2244 (2013)
"Low-molecular-weight CXCR4 ligands with variable spacers."
T. Narumi; H. Aikawa; T. Tanaka; C. Hashimoto; N. Ohashi; W. Nomura; T. Kobayakawa; H. Takano; Y. Hirota; T. Murakami; N. Yamamoto; H. Tamamura
ChemMedChem, 8, 118-124 (2013)
"Pharmacophore-based small molecule CXCR4 ligands."
T. Narumi; T. Tanaka; C. Hashimoto; W. Nomura; H. Aikawa; A. Sohma; K. Itotani; M. Kawamata; T. Murakami; N. Yamamoto; H. Tamamura
Bioorg Med Chem Lett, 22, 4169-4172 (2012)
"Stereoselective formation of trisubstituted (Z)-chloroalkenes adjacent to a tertiary carbon stereogenic center by organocuprate-mediated reduction/alkylation."
T. Narumi; T. Kobayakawa; H. Aikawa; S. Seike; H. Tamamura
Org Lett, 14, 4490-4493 (2012)
"Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines."
C. Hashimoto; W. Nomura; A. Ohya; E. Urano; K. Miyauchi; T. Narumi; H. Aikawa; J.A. Komano; N. Yamamoto; H. Tamamura
Bioorg Med Chem, 20, 3287-3291 (2012)
"Formation of double helix self-assembled monolayers of ethynylhelicene oligomer disulfides on gold surfaces."
K. Yamamoto; H. Sugiura; R. Amemiya; H. Aikawa; Z.J. An; M. Yamaguchi; M. Mizukami; K. Kurihara
Tetrahedron, 67, 5972-5978 (2011)
"Synthesis of 1,8-di(1-adamantyl)naphthalenes as single enantiomers stable at ambient temperatures."
H. Aikawa; Y. Takahira; M. Yamaguchi
Chem Commun (Camb), 47, 1479-1481 (2011)
"Gold-catalyzed alkylation of silyl enol ethers with ortho-alkynylbenzoic acid esters."
H. Aikawa; T. Kaneko; N. Asao; Y. Yamamoto
Beilstein J Org Chem, 7, 648-652 (2011)
"Gold-catalyzed substitution reaction with ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent."
H. Aikawa; S. Tago; K. Umetsu; N. Haginiwa; N. Asao
Tetrahedron, 65, 1774-1784 (2009)
"Gold-catalyzed etherification and Friedel-Crafts alkylation using ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent."
N. Asao; H. Aikawa; S. Tago; K. Umetsu
Org Lett, 9, 4299-4302 (2007)
"Lewis acid-catalyzed [4 + 2] benzannulation between enynal units and enols or enol ethers: novel synthetic tools for polysubstituted aromatic compounds including indole and benzofuran derivatives."
N. Asao; H. Aikawa
J Org Chem, 71, 5249-5253 (2006)
"AuBr(3)-catalyzed [4 + 2] benzannulation between an enynal unit and enol."
N. Asao; H. Aikawa; Y. Yamamoto
J Am Chem Soc, 126, 7458-7459 (2004)

連絡先

    • E-mail… aikawa.haruo@(@以下はmail.u-tokyo.ac.jp)