Yichao Huang黃 軼超
Postdoctoral Fellow
- City/country of origin
- Shanghai, China
- Hobbies
- Jogging, reading, playing harmonica occassionally ...
- Places You Like
- With blue sky and no haze.
- Where for a big vacation
- Other places in Japan, Hokkaido, Okinawa ...
- What are your strong points?
- Naive smile, maybe.
- Music: what is some intense music for intense lab work?
- あなただけみつめてる、YAH YAH YAH
- What are people in the lab doing?
- Switching roles between synthetic chemist and synthetic biologist.
- What was surprising about the suga lab
- A lot of brainstorming.
- Original motivation towards science?
- Seeing a chemical structure on the label of a flu drug bottle.
- A few words for future lab mates
- Studying some Hiragana and Katakana letters can be helpful.
- Science is ……
- The more you discover, the more is waiting to be explored.
Education & professional career
- 2007-2011
- B.S., Chemical Biology, Tsinghua University
- 2011-2016
- PhD, Bioorganic Chemistry, Tsinghua University
- 2016-present
- Postdoctoral fellow, Bioorganic Chemistry, The University of Tokyo
Publications
- "Chemical Synthesis of K48-Linked Diubiquitin by Incorporation of a Lysine-Linked Auxiliary Handle."
- R.-L. Xie; L. Xu; J.-B. Li; G.-C. Chu; T. Wang; Y.-C. Huang; Y.-M. Li
- European Journal of Organic Chemistry, 2665-2670 (2016)
- "Hmb(off/on) as a switchable thiol protecting group for native chemical ligation."
- Y.-K. Qi; S. Tang; Y.-C. Huang; M. Pan; J.-S. Zheng; L. Liu
- Organic & Biomolecular Chemistry, 14, 4194-4198 (2016)
- "Quasi-Racemic X-ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis."
- M. Pan; S. Gao; Y. Zheng; X. Tan; H. Lan; X. Tan; D. Sun; L. Lu; T. Wang; Q. Zheng; Y. Huang; J. Wang; L. Liu
- Journal of the American Chemical Society, 138, 7429-7435 (2016)
- "Ubiquitin 7-amino-4-carbamoylmethylcoumarin as an improved fluorogenic substrate for deubiquitinating enzymes."
- Y.-T. Li; Y.-C. Huang; Y. Xu; M. Pan; Y.-M. Li
- Tetrahedron, 72, 4085-4090 (2016)
- "KAHA Ligation at Serine."
- Y.-M. Li; Y.-C. Huang; L. Liu
- Chembiochem, 17, 28-30 (2016)
- "Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation."
- H. Lan; K. Wu; Y. Zheng; M. Pan; Y.-C. Huang; S. Gao; Q.-Y. Zheng; J.-S. Zheng; Y.-M. Li; B. Xiao; L. Liu
- Journal of peptide science : an official publication of the European Peptide Society, 22, 320-326 (2016)
- "Chemical synthesis of proteins using hydrazide intermediates."
- Y.-C. Huang; G.-M. Fang; L. Liu
- National Science Review, 3, 107-116 (2016)
- "Synthesis of l- and d-Ubiquitin by One-Pot Ligation and Metal-Free Desulfurization."
- Y.-C. Huang; C.-C. Chen; S. Gao; Y.-H. Wang; H. Xiao; F. Wang; C.-L. Tian; Y.-M. Li
- Chemistry (Weinheim an der Bergstrasse, Germany), 22, 7623-7628 (2016)
- "Protein modification: Standing out from the crowd."
- Y. Huang; L. Liu
- Nature chemistry, 8, 101-102 (2016)
- "Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones."
- Y.-C. Huang; C.-J. Guan; X.-L. Tan; C.-C. Chen; Q.-X. Guo; Y.-M. Li
- Organic & Biomolecular Chemistry, 13, 1500-1506 (2015)
- "Chemical synthesis of crystalline proteins."
- Y. Huang; L. Liu
- Science China-Chemistry, 58, 1779-1781 (2015)
- "Irreversible Site-Specific Hydrazinolysis of Proteins by Use of Sortase."
- Y.-M. Li; Y.-T. Li; M. Pan; X.-Q. Kong; Y.-C. Huang; Z.-Y. Hong; L. Liu
- Angewandte Chemie-International Edition, 53, 2198-2202 (2014)
- "Facile synthesis of C-terminal peptide hydrazide and thioester of NY-ESO-1 (A39-A68) from an Fmoc-hydrazine 2-chlorotrityl chloride resin."
- Y.-C. Huang; C.-C. Chen; S.-J. Li; S. Gao; J. Shi; Y.-M. Li
- Tetrahedron, 70, 2951-2955 (2014)
- "Facile solid-phase synthesis of PNA-peptide conjugates using pNZ-protected PNA monomers."
- Y.-C. Huang; C. Cao; X.-L. Tan; X. Li; L. Liu
- Organic Chemistry Frontiers, 1, 1050-1054 (2014)
- "Thiol-assisted one-pot synthesis of peptide/protein C-terminal thioacids from peptide/protein hydrazides at neutral conditions."
- C. Chen; Y. Huang; L. Xu; Y. Zheng; H. Xu; Q. Guo; C. Tian; Y. Li; J. Shi
- Organic & Biomolecular Chemistry, 12, 9413-9418 (2014)
- "Development of New Thioester Equivalents for Protein Chemical Synthesis."
- J.-S. Zheng; S. Tang; Y.-C. Huang; L. Liu
- Accounts of Chemical Research, 46, 2475-2484 (2013)
- "Thiol-yne radical reaction mediated site-specific protein labeling via genetic incorporation of an alkynyl-L-lysine analogue."
- Y. Li; M. Pan; Y. Li; Y. Huang; Q. Guo
- Organic & Biomolecular Chemistry, 11, 2624-2629 (2013)
- "Synthesis of Autophagosomal Marker Protein LC3-II under Detergent-Free Conditions."
- Y.-C. Huang; Y.-M. Li; Y. Chen; M. Pan; Y.-T. Li; L. Yu; Q.-X. Guo; L. Liu
- Angewandte Chemie-International Edition, 52, 4858-4862 (2013)
- "Ligation of Expressed Protein alpha-Hydrazides via Genetic Incorporation of an alpha-Hydroxy Acid."
- Y.-M. Li; M.-Y. Yang; Y.-C. Huang; Y.-T. Li; P.R. Chen; L. Liu
- Acs Chemical Biology, 7, 1015-1022 (2012)
- "Genetically encoded alkenyl-pyrrolysine analogues for thiol-ene reaction mediated site-specific protein labeling."
- Y. Li; M. Yang; Y. Huang; X. Song; L. Liu; P.R. Chen
- Chemical Science, 3, 2766-2770 (2012)
- "Chemical Synthesis of Integral Membrane Proteins: Methods and Applications."
- F. Shen; Y.-C. Huang; S. Tang; Y.-X. Chen; L. Liu
- Israel Journal of Chemistry, 51, 940-952 (2011)
- "Protein Chemical Synthesis by Ligation of Peptide Hydrazides."
- G.-M. Fang; Y.-M. Li; F. Shen; Y.-C. Huang; J.-B. Li; Y. Lin; H.-K. Cui; L. Liu
- Angewandte Chemie-International Edition, 50, 7645-7649 (2011)
Contact info
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- E-mail… hycjimmy"at"chem.s.u-tokyo.ac.jp (change "at" to @)