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Philosophy of Suga lab.

In the Suga lab, our aim is to utilize organic chemistry techniques in combination with biology to tackle yet unresolved questions. In our inclusive research, we procure scientific knowledge leading to new concepts and develop novel technologies with broad applicability, which can extend to drug discovery. We provide a diligent and cooperative research environment with a goal of nurturing individuals so they are brimming with innovation and global-mindedness.
We also added three other papers into the publication list.

Lab News

Jun, 2017:
Drs. Obexer and Walport won the grand prix award and TOP 5 presentation award, respectively, in the Young Investigator Poster Competition at 9th International Peptide Symposium (Whistler, Canada). Congrats!
Apr, 2017:
Dr. Kato (graduated in this March) won the oral presentation award at the 97th CSJ annual meeting. Congrats!
Mar, 2017:
Mr. Kojima’s paper regarding macrocyclic peptides inhibiting a histone demethylase has been published in Nature Communications!→link
Mar, 2017:
Dr. Yu’s paper regarding macrocyclic peptides inhibiting a glycosidase has been published in Nature Communications!→link
Mar, 2017:
Associate Professor Goto won the CSJ Award for Young Chemists. Congrats!
Mar, 2017:
Dr. Jongkees's paper regarding macrocyclic peptides inhibiting a phosphoglycerate mutase has been published in Cell Chemical Biology!→link
Feb, 2017:
Associate Professor Goto's paper regarding in vitro biosynthesis of goadsporin (collaboration with Prof. Onaka) has been published in Nature Communications!→link. See here for the press release.
Jan, 2017:
Assistant Professor Katoh's paper regarding consecutive elongation of D-amino acids in translation has been published in Cell Chemical Biology→link We also added one review paper into the publication list.
Dec, 2016:
Dr. Terasaka's paper regarding a microRNA precursor binding to folic acidhas been published in RNA!→link
Nov, 2016:
Dr. Bashiruddin's paper regarding allosteric Inhibitors of Plexin B1 has been published in Cell Chemical Biology!→link We also added five other papers into the publication list.
Nov, 2016:
Professor Suga was awarded the Special Award in Japan Inovator Award 2016. Congratulations!!→link
Nov, 2016:
Dr. Jongkees's paper regarding ribosomnal synthesis of macrocyclic peptides bearing carbohydrates has been published in Chemical Science!→link
Oct, 2016:
Associate Professor Goto won the Young Investigator Award from the Japanese Peptide Society. Congrats!
Oct, 2016:
Mr. Yoshikane (M2) won the poster presentation award at the 53rd Japanese Peptide Symposium. Congrats!
Oct, 2016:
Professor Suga won the Max Bergmann-Medal! Congrats!!
Oct, 2016:
Associate Professor Goto's paper regarding substrate tolerance of PatD has been published in Chemistry Letters. This paper has been highlighted as Editor's Choice→link
Sep, 2016:
Dr. Yin won the JSPS fellowship. Congrats!
Aug, 2016:
We won the Best Crazy Award (1st prize in the lab introduction section) at the 48th Peptide Summer School! → pic
Aug, 2016:
Mr. Otero (M2) won the Excellent Poster Award at the 48th Peptide Summer School. Congrats! → pic
July, 2016:
Suga Lab won a victory at the softball tournament of the faculty!→ pic
Jul, 2016:
Mr. Iwane (D3) won won the poster award in "創薬懇話会2016 (drug development meeting 2016)". Congrats!
June, 2016:
Mr. Iwane (D3) won the best award in "第30回 独創性を拓く 先端技術大賞" (the 30th advanced technology award). Congrats!
May, 2016:
Mr. Nishio (D3) won the oral presentation award at the 96th CSJ annual meeting. Congrats!
May, 2016:
Assistant Professor Katoh's paper regarding essential structural elements in tRNAPro for EF-P recognition has been published in Nature Communications→link
May, 2016:
Dr. Futai's paper regarding a tRNA-removal methodology has been published in Methods!→link
Apr, 2016:
Dr. Hirose, Dr. Maini, Mr. Ishida, and Mr. Ozawa won JSPS fellowship. Congrats!
Apr, 2016:
We welcomed eight new members the lab!
Mar, 2016:
Mr. Ishida and Mr. Takeue won the scholar of excellence award from Graduate school of Science and Department of Chemistry, respectively. Congrats!
Mar, 2016:
Three members graduated from the lab.
Mar, 2016:
Professor Suga won the Gold Medal Award from the Yomiuri Techno Forum! Congrats!!→link
Mar, 2016:
Mr. Yasuharu Kato's presentation planned at the 96th CSJ annual meeting was selected as a Highlight Presentation! This topic has been reported in the Nikkei Biotech.→link
Feb, 2016:
Mr. Iwane's paper regarding artificial division of codon boxes has been published in Nature Chemistry!→link We also added two other papers into the publication list.
Jan, 2016
Assistant Professor Goto won the Excellent Poster Award in the 8th Takeda Science Foundation Symposium on PharmaSciences!
Dec, 2015:
Dr. Iwasaki's paper regarding fluorescent peptidic probe of EpCAM has been published in the in vitro selection special issue of Journal of Molecular Evolution!→link. We also added two other papers into the publication list.
Sep, 2015:
Dr. Obexer won the JSPS fellowship. Congrats!
Aug, 2015:
Drs. Bashiruddin and Nagano's paper regarding expression of tricyclic peptides has been published in Bioorganic Chemistry!→link. We also added three other papers into the publication list.
Aug, 2015:
Mr. Yoshikane (M1) won the poster presentation award at the 47th Young Investigators' Summer School of Peptide Chemistry. Congrats!
Apr, 2015:
Professor Suga won the Prize for Science and Technology by the Minister! Congrats!→link
Apr, 2015:
Mr. Kato won JSPS fellowship. Congrats!
Apr, 2015:
We welcomed eleven new members the lab!
Mar, 2015:
Dr. Terasaka and Mr. Yoshikane won the scholar of excellence award from Graduate school of Science and Department of Chemistry, respectively.
Mar, 2015:
Eight members graduated from the lab.
Mar, 2015:
Dr. Ito's paper regarding artificial agonist of cMet has been published in Nature Communications!→link
Oct, 2014:
Professor Suga won the Akabori Memorial Award 2014!→link
Oct, 2014:
Mr. Ishida (M1) and Mr. Ozawa (M2) won ALPS scholarship and MERIT scholarship, respectively.
Sep, 2014:
Mr. Terasaka (D3) won the Sidney Altman Endowment Travel Award at the 25th tRNA conference! Congrats!
Aug, 2014:
Mr. Ishida (M1) and Mr. Nishio (D1) won the oral presentation award and poster presentation award, respectively, at the 46th Young Investigators' Summer School of Peptide Chemistry. Congrats!
Jul, 2014:
Mr.Yoshikane (B4) won the ICE Seminar Best Poster award at 6th AEC, BAEC-I&II Summer ICE Seminar!
May, 2014:
Mr. Terasaka and Dr. Hayashi's paper regarding orthogonal ribosome has been published in Nature Chemical Biology!→link. See here for the press release.
May, 2014:
Ms. Ito and Dr. Goto's paper regarding one-pot biosynthesis of azoline-containing peptides has been published in Chemistry & Biology!→link
Apr, 2014:
Dr. Loik, Mr. Iwane, Mr. Nishio, and Mr. Kato won fellowships. Congrats!
Apr, 2014:
Dr. Passioura has been promoted to assistant professor!
Apr, 2014:
We welcomed five new members the lab!
Mar, 2014:
Eight students graduated from the lab.
Good luck on their future careers!
Dec, 2013:
Suga Lab won a victory at the football tournament of the faculty!→link for a picture
Nov, 2013
Mr. Yamaguchi (D1) won the poster presentation award at the 3rd CSJ Chemistry Festa!
Nov, 2013
Assistant Professor Goto won the Excellent Stone Award in APIPS2013!
Oct, 2013
Mr. Iwane (M2) and Mr. Ito (D3) won the poster presentation award at the 9th International Symposium on Aminoacyl-tRNA Synthetases (AARS2013). Congrats!
Oct, 2013
Our paper regarding reprogrammed dual sense codons has been published in ACS Chemical Biology!→link
Sep, 2013
Assistant Professor Goto won the Presentation Award in the Biofunctional Chemistry devision of CSJ!
Sep, 2013
Mr. Kimura (M1) and Ms. Song (M2) won MERIT scholarship and ALPS scholarship, respectively. Congrats!
Aug, 2013
Dr. Hipolito's paper regarding pfMATE-binding peptides has been published in Molecules!→link
Aug, 2013
Mr. Terasaka (D2) won the presentation award at the 15th Annual Meeting of the RNA Society of Japan. Congrats!
July, 2013
Mr. Yasuharu Kato (M2) and Mr. Ryo Takatsuji won the best oral presentation award and poster presentation award, respectively, at the 45th Young Investigators' Summer School of Peptide Chemistry. Congrats!
July, 2013
Assistant Professor Katoh won the Rising Star Award from Japan Science and Technology Agency!
July, 2013
Suga Lab won a victory at the softball tournament of the faculty!→link for pictures
May, 2013:
The first Suga lab alumni party: Over 80 former and current lab members celebrated the 10th anniversary of the Suga Lab at the University of Tokyo.→link for a picture
Apr, 2013:
Assistant Professor Goto won the CSJ Presentation Award in the 93rd Annual Meeting of the Chemical Society of Japan!
Apr, 2013:
Assistant Professor Goto won the Young Scientists Prize by the Minister of MEXT!
Apr, 2013:
Dr. Nagano and Dr. Yoshitomi won fellowships (PD) from the JSPS. Congrats!
Apr, 2013:
We welcomed eight new members the lab!
May, 2013:
Three Ph.D. students (Dr. Iida, Dr. Shimomai, Dr. Reza) graduated from the lab.
Good luck on their future careers!
Feb, 2013:
Professor Suga won the CSJ Award for Creative Work!→link
Feb, 2013:
Our paper has been accepted by Nature! It regards the Dr. Hipolito's work where crystal structures of pfMATE protein binding to new macrocyclic peptides were solved.
Jan, 2013:
Dr. Nagano (postdoc) won the Teijin Pharma Award in Synthetic Organic Chemistry. Congrats!
Dec, 2012:
Suga Lab won a victory at the football tournament of the faculty!→link for a picture
Sep, 2012:
Mr. Ito (D2 student) won a poster presentation award at the 27th forum for young researchers in biofunctional chemistry. Congrats!
Jan, 2012:
SciBX (Nature publishing group) featured our research regarding discovery of bioactive peptides powered by the RaPID system.→link
2012年6月:
M1の井関さんが6/8に開催された新規素材探索研究会第11回セミナーにおいて、新規素材探索奨励賞を受賞しました。おめでとう!
2012年5月:
ポスドクの林さん・柴田さんが菅研を巣立っていきました。
新しい職場での活躍を願っています!
2012年4月:
3月に行われた日本化学会において、森本君が学生講演賞を受賞しました。おめでとう!
2012年4月:
林剛介さんが日本学術振興会の海外特別研究員採用されました!アメリカでの素晴らしい研究成果を期待しています。
2012年4月:
藤田さんが日本学術振興会の特別研究員(PD)に、寺坂君が特別研究員(DC1)にそれぞれ採用されました!
2012年4月:
今年度の新メンバーが加入しました。ポスドク2人・博士課程1人・修士課程4人・学部生4人が加わり、また賑やかになります!
2012年3月:
ポスドクの二井さん・Mengさん、博士課程の五十嵐さん・岩崎君・森本君、修士課程の伊藤さんが無事研究室を巣立っていきました!
長い間どうもありがとうございました。これからも新天地で頑張って下さい。
2012年3月:
日本化学会第92春季年会のATPセッションにおいて、森本君が注目ポスター賞を受賞しました。おめでとう!
2012年3月:
D3岩崎君の翻訳ペプチドのチオエーテル環化の論文がOrganic & Biomolecular Chemistryに掲載決定!
OBCの10周年記念号に掲載予定です。 →リンク
"Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation"
2012年2月:
D3森本君のsirtuinの阻害剤の論文がAngewandte Chemie International Editionに掲載決定! →リンク
"Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead: Isoform-Selective Inhibition of Human Deacetylase SIRT2"
2012年2月:
卒業生の進路に関するページを追加しました。→リンク
2012年1月:
選択的Akt2阻害ペプチドの論文がACS Chemical Biologyに掲載決定! →リンク
"In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors" …林勇樹
2011年12月:
後藤助教の研究課題がJST戦略的創造研究推進事業(さきがけ)「細胞機能の構成的な理解と制御」領域に採択されました!
『人工二次代謝産物』の創成を目指して研究を推進していきます。→リンク
2011年11月:
特殊ペプチドの試験管内人工進化の論文がChemistry&Biology誌に掲載決定! →12月号に掲載
"Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library" …山岸祐介
Nature publishing groupのSciBXからインタビューを受けました。近日中に記事が掲載されます。
2011年11月:
岩根君が全国国公立大学空手道選手権大会にて団体優勝!
優秀選手賞も受賞したそうです。おめでとう!
2011年11月:
Hipolitoさんが日本学術振興会の外国人特別研究員に採用されました!
2011年9月:
菅教授が産学官連携功労者表彰 日本学術会議会長賞を受賞しました! →リンク
"創薬プラットフォーム技術「RAPIDシステム」の実用化"…ぺプチドリーム株式会社との共同受賞
2011年8月:
Proc. Natl. Acad. Sci. USA誌に論文掲載決定! →リンク
"Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum" …樋口岳、von Heijne研との共同研究
2011年5月:
Nature Protocols に掲載決定! →リンク
"Flexizymes for genetic code reprogramming" …後藤佑樹、加藤敬行
2011年5月:
ChemBioChem に掲載決定! →リンク
"Ribosomal Synthesis of Backbone-Macrocyclic Peptides Containing γ-Amino Acids" …大城幸紀、中島永二、後藤佑樹
表紙にも選ばれました!
2011年4月:
伊藤君が日本学術振興会の特別研究員(DC1)に採用されました!
2011年1月:
Angewandte Chemie International Edition に掲載決定! →リンク
"Synthesis of the Backbone Cyclic Peptide Sunflower Trypsin Inhibitor-1 Promoted by the Induced Peptidyl-tRNA Drop-off" …T.-J. Kang、林勇樹
2010年12月:
第五回国際ペプチドシンポジウム in 京都
オーラルプレゼン賞受賞…山岸祐介(3年連続で菅研獲得!)
ポスター賞受賞…林勇樹、大城幸紀、森本淳平の3人が受賞
2010年9月:
日本化学会生体機能関連化学部会 第25回若手フォーラム ポスター賞受賞…森本淳平