Shu KobayashiProfessor, Synthetic Organic Chemistry
Office:
Phone:
03-5841-4790
Fax:
03-5684-0634
E-mail:
Research and Professional Experience:
1987 Assistant Professor; Science University of Tokyo (SUT)
1991 Lecturer; Science University of Tokyo (SUT)
1992 Associate Professor; Science University of Tokyo (SUT)
1993 Visiting Professor, Universite Louis Pasteur; Strasbourg, France
1995 Visiting Professor, Kyoto University
1996 Visiting Professor, Nijmegen University, The Netherlands
1997 Visiting Professor, Philipps-Universitat Marburg, Germany
1997 Special Promoted Researcher (SUT, 1997-1998)
1997 CREST Investigator (JST, 1997-2001)
1998 Full Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2002 SORST Investigator (JST, 2002-2004)
2003 ERATO Investigator (JST, 2003-)
2007 Full Professor, Department of Chemistry, School of Science, The University of Tokyo
Awards:
1991 The Chemical Society of Japan Award for Young Chemists
1992 Teijin Award in Synthetic Organic Chemistry, Japan
1992 New Chemistry Institute Research Award
1993 Nissan Science Foundation for Younger Generation
1994 Ciba-Geigy Research Foundation
1995 Kurata Research Foundation
1997 Springer Award in Organometallic Chemistry
1999 Bio-Mega/Boehrinder Ingelheim Lecturer
1999 Merck-SFC Lectureship
1999 Wyeth-Ayerst Lectureship
2000 Novartis Chemistry Lectureship
2000 MIT/Wyeth-Ayerst Lectureship
2000 Nagoya Lectureship
2001 Roche Lectureship
2001 NPS Distinguished Lecturer
2001 IBM Science Award
2002 Organic Reactions Lecturer
2002 Nagoya Silver Medal
2003 Novo-Nortis Lectureship
2004 Manchester-Merck Lecturer
2005 Mitsui Chemical Catalysis Science Award
2005 JSPS Prize
2006 Arthur C. Cope Scholar Awards
2006 Howard Memorial Lecturer
Synthetic Organic Chemistry, Organometallic Chemistry
Research Interests:
Research Subjects:
(1) Development of highly-functionalized reaction environments in water
(2) Development of polymer-supported catalysts
(3) Development of highly efficient catalytic asymmetric reactions using novel environments
Publications:
1. Catalytic Asymmetric Animation of Enecarbamates, R. Matsubara, S. Kobayashi, Angew. Chem. Int. Ed., 2006, 45, 7993-7995.
2. A Heterogeneous Silica-Supported Scandium/Ionic Liquid Catalyst System for Organic Reactions in Water, Y. Gu, C. Ogawa, J. Kobayashi, Y. Mori, S. Kobayashi, Angew. Chem. Int. Ed., 2006, 45, 7217-7220.
3. Enantioselective Transfer Aminoallylation: Synthesis of Optically Active Homoallylic Primary Amines, M. Sugiura, C. Mori, S. Kobayashi, J. Am. Chem. Soc., 2006 128, 11038-11039.
4. Remarkably Stable Chiral Zirconium Complexes for Asymmetric Mannich-type Reactions, K. Saruhashi, S. Kobayashi, J. Am. Chem. Soc., 2006, 128, 11232-11235.
5. Highly anti-Selective Catalytic Aldol Reactions of Amides with Aldehydes, S. Saito, S. Kobayashi, J. Am. Chem. Soc., 2006, 128, 8704-8705.
6. With Molecular-Oxygen-Activated Lewis Acids: Dinuclear Molybdenum Complexes for Aza-Diels-Alder Reactions of Acyl Hydrazones, Y. Yamashita, M. M. Salter, K. Aoyama, S. Kobayashi, Angew. Chem. Int. Ed., 2006, 45, 3816-3819.
7. Catalytic Enantioselective and Diastereoselective Addition of Aldehyde-Derived Enecarbamates to α-Oxo Aldehydes, R. Matsubara, N. Kawai, S. Kobayashi, Angew. Chem. Int. Ed., 2006, 45, 3814-3816.
8. Enantiomerically Enriched Allylglycine Derivatives Through the Catalytic Asymmetric Allylation of Iminoesters and Iminophosphonates with Allylsilanes, H. Kiyohara, Y. Nakamura, R. Matsubara, S. Kobayashi, Angew. Chem. Int. Ed., 2006, 45, 1615-1617.
9. Chiral Zirconium Catalysts Using Multidentate BINOL Derivatives for Catalytic Enantioselective Mannich-Type Reactions; Ligand Optimization and Approaches to Elucidation of the Catalyst Structure, Y. Ihori, Y. Yamashita, H. Ishitani, S. Kobayashi, J. Am. Chem. Soc., 2005, 127, 15528-15535.
10. Polymer-Micelle Incarcerated Scandium as a Polymer-Supported Catalyst for High-Throughput Organic Synthesis, M. Takeuchi, R. Akiyama, S. Kobayashi, J. Am. Chem. Soc., 2005, 127, 13096-13097.
11. Highly Active, Immobilized Ruthenium Catalysts for Oxidation of Alcohols to Aldehydes and Ketones. Preparation and Use in Both Batch and Flow Systems, S. Kobayashi, H. Miyamura, R. Akiyama, T. Ishida, J. Am. Chem. Soc., 2005, 127, 9251-9254.
12. N-Acylhydrazones as Versatile Electrophiles for the Synthesis of Nitrogen-containing Compounds, M. Sugiura, S. Kobayashi, Angew. Chem. Int. Ed., 2005, 44, 5176-5186.
13. A Novel Dinuclear Chiral Niobium Complex for Lewis Acid Catalyzed Enanioselective Reactions; Design of a Tridentate Ligand and Elucidation of the Catalyst Structure, S. Kobayashi, K. Arai, H. Shimizu, Y. Ihori, H. Ishitani, Y. Yamashita, Angew. Chem. Int. Ed., 2005, 44, 761-764.
14. Formation of Nanoarchitectures Including Subnanometer Palladium Clusters and Their Use as Highly Active Catalysts, K. Okamoto, R. Akiyama. H. Yoshida, T. Yoshida, S. Kobayashi, J. Am. Chem. Soc., 2005, 127, 2125-2135.
15. Stereospecific, Enantioselective Allylation of α-Hydrazono Esters Using Allyltrichlorosilanes with BINAP Dioxides as Neutral-Coordinate Organocatalysts, C. Ogawa, M. Sugiura, S. Kobayashi, Angew. Chem. Int. Ed., 2004, 43, 6491-6493.
16. Catalytic Asymmetric Hydroxymethylation of Silicon Enolates Using an Aqueous Solution of Formaldehyde with a Chiral Scandium Complex, S. Ishikawa, T. Hamada, K. Manabe, S. Kobayashi, J. Am. Chem. Soc., 2004, 126, 12236-12237.
17. Zirconium-Catalyzed Enantioselective [3+2] Cycloaddition of Hydrazones to Olefins Leading to Optically Active Pyrazolidine, Pyrazoline, and 1,3-Diamine Derivatives, Y. Yamashita, S. Kobayashi, J. Am. Chem. Soc., 2004, 126, 11279-11282.
18. Catalytic Enantio- and Diastereoselective Aldol Reactions of Glycine-Derived Silicon Enolate with Aldehydes: An Efficient Approach to the Asymmetric Synthesis of Anti-β-Hydroxy-α-Amino Acid Derivatives, J. Kobayashi, M. Nakamura, Y. Mori, Y. Yamashita, S. Kobayashi, J. Am. Chem. Soc., 2004, 126, 9192-9193.
19. Enantio- and Diastereoselective, Stereospecific Mannich-Type Reaction in Water, T. Hamada, K. Manabe, S. Kobayashi, J. Am. Chem. Soc., 2004, 126, 7768-7769.
20. Catalytic Asymmetric Synthesis of α-Amino Phosphonates Using Enantioselective Carbon-Carbon Bond-Forming Reactions, S. Kobayashi, H. Kiyohara, Y. Nakamura, R. Matsubara, J. Am. Chem. Soc., 2004, 126, 6558-6559.
21. A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions, J. Kobayashi, Y. Mori, K. Okamoto, R. Akiyama, M. Ueno, T. Kitamori, S. Kobayashi, Science, 2004, 304, 1305-1308.
22. α-Aminoallylation of Aldehydes with Ammonia: Stereoselective Synthesis of Homoallylic Primary Amines, M. Sugiura, K. Hirano, S. Kobayashi, J. Am. Chem. Soc., 2004, 126, 7182-7183.
23. Air-Stable, Storable, and Highly Efficient Chiral Zirconium Catalysts for Enantioselective Mannich-type, aza Diels-Alder, Aldol, and Hetero Diels-Alder Reactions, S. Kobayashi, M. Ueno, S. Saito, Y. Mizuki, H. Ishitani, Y. Yamashita, Proc. Natl. Acad. Sci. USA, 2004, 101, 5476-5481.
24. Copper(II)-Catalyzed Highly Enantioselective Addition of Enamides to Imines: The Use of Enamides as Nucleophiles in Asymmetric Catalysis, R. Matsubara, Y. Nakamura, S. Kobayashi, Angew. Chem. Int. Ed., 2004, 43, 1679-1681.
25. Catalytic Asymmetric Allylation of Hydrazono Esters in Aqueous Media Using by ZnF2-Chiral Diamine, T. Hamada, K. Manabe, S. Kobayashi, Angew. Chem. Int. Ed., 2003, 42, 3927-3930.
26. Chiral Sulfoxides as Neutral Coordinate-Organocatalysts in Asymmetric Allylation of N-Acylhydrazones Using Allyltrichlorosilanes, S. Kobayashi, C. Ogawa, H. Konishi, M. Sugiura, J. Am. Chem. Soc., 2003, 125, 6610-6611.
27. Catalytic Asymmetric Aldol Reactions in Aqueous Media Using Chiral Bis-pyridino-18-crown-6-Rare Earth Metal Triflate Complexes, T. Hamada, K. Manabe, S. Ishikawa, S. Nagayama, M. Shiro, S. Kobayashi, J. Am. Chem. Soc., 2003, 125, 2989-2996.
28. The Polymer Incarcerated Method for the Preparation of Highly Active Heterogeneous Palladium Catalysts, R. Akiyama, S. Kobayashi, J. Am. Chem. Soc., 2003, 125, 3412-3413.
29. Chiral Hetero Diels-Alder Products by Enantioselective and Diastereoselective Zirconium Catalysis. Scope, Limitation, Mechanism, and Application to the Concise Synthesis of (+)-Prelactone C and (+)-9-Deoxygoniopypyrone, Y. Yamashita, S. Saito, H. Ishitani, S. Kobayashi, J. Am. Chem. Soc., 2003, 125, 3793-3798.
30. Catalytic, Asymmetric Mannich-Type Reactions of N-Acylimino Esters: Reactivity, Diastereo- and Enantioselectivity, and Application to Synthesis of N-Acylated Amino Acid Derivatives, S. Kobayashi, R. Matsubara, Y. Nakamura, H. Kitagawa, M. Sugiura, J. Am. Chem. Soc., 2003, 125, 2507-2515.
31. Asymmetric Intramolecular [3+2] Cycloaddition Reactions of Acylhydrazones/olefins Using a Chiral Zirconium Catalyst, S. Kobayashi, H. Shimizu, Y. Yamashita, H. Ishitani, J. Kobayashi, J. Am. Chem. Soc., 2002, 124, 13678-13679.
32. Dehydration Reactions in Water. Br遵k面野齡ed Acid- Surfactant-Combined Catalyst for Ester, Ether, Thioether, and Dithioacetal Formation in Water, K. Manabe, S. Iimura, X.-M. Sun, S. Kobayashi, J. Am. Chem. Soc., 2002, 124, 11971-11978.
33. A Novel Polymer-Supported Arene-Ruthenium Complex for Ring-Closing Olefin Metathesis, R. Akiyama, S. Kobayashi, Angew. Chem. Int. Ed., 2002, 41, 2602-2604.
34. The Catalytic Asymmetric Mannich-Type Reactions in Aqueous Media, S. Kobayashi, T. Hamada, K. Manabe, J. Am. Chem. Soc., 2002, 124, 5640-5641.
35. Highly Anti-Selective Asymmetric Aldol Reactions Using Chiral Zirconium Catalysts. Improvement of Activities, Structure of the Novel Zirconium Complexes, and Effect of a Small Amount of Water for the Preparation of the Catalysts, Y. Yamashita, H. Ishitani, H. Shimizu, S. Kobayashi, J. Am. Chem. Soc., 2002, 124, 3292-3302.